Method and apparatus for penetrating tissue

Title:

Method and apparatus for penetrating tissue

Document Type and Number:

United States Patent 7331931

Abstract:

These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generator moves the member along a path out of a housing having a penetrating member exit, into the tissue site, stops in the tissue site, and withdraws out of the tissue site. A cartridge houses the penetrating member. The cartridge has first and second seals coupled to the penetrating member to maintain a sterile environment around a portion of the penetration member prior to penetrating member actuation. A user interface is configured to relay at least one of, penetrating member performance or a penetrating member setting.

Inventors:

Freeman, Dominique M. (La Honda, CA, US)
Boecker, Dirk (Palo Alto, CA, US)
Alden, Don (Sunnyvale, CA, US)

Plaque It!

Sponsored by:
Flash of Genius

Application Number:

10/335218

Publication Date:

02/19/2008

Filing Date:

12/31/2002

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Export Citation:

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Assignee:

Pelikan Technologies, Inc. (Palo Alto, CA, US)

Primary Class:

600/583

Other Classes:

606/181, 606/1

International Classes:

A61B5/00

Field of Search:

600/573, 606/183, 606/172, 606/167, 606/181, 600/576-579, 606/182, 600/583

US Patent References:

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4820010	Bright output optical system with tapered bundle	April, 1989	Sciefres	385/43
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4895147	Lancet injector	January, 1990	Bodicky	606/182
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4990154	Lancet assembly	February, 1991	Brown	606/182
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5010772	Pressure mapping system with capacitive measuring pad	April, 1991	Bourland	73/862.04
5010774	Distribution type tactile sensor	April, 1991	Kikuo	73/862.04
5014718	Blood collection and testing method	May, 1991	Mitchen	128/771
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5035704	Blood sampling mechanism	July, 1991	Lambert et al.	606/182
5047044	Medical droplet whole blood and like monitoring	September, 1991	Smith et al.	606/182
5054499	Disposable skin perforator and blood testing device	October, 1991	Swierczek	128/770
5059789	Optical position and orientation sensor	October, 1991	Salcudean	250/206.1
5060174	Method and apparatus for evaluating a load bearing surface such as a seat	October, 1991	Gross	702/139
5070886	Blood collection and testing means	December, 1991	Mitchen	128/771
5074872	Lancet assembly	December, 1991	Brown	606/182
5089112	Electrochemical biosensor based on immobilized enzymes and redox polymers	February, 1992	Skotheim	204/403
5092842	Injection device with a cocking element and a second setting element	March, 1992	Bechtold	604/135
5097810	Allergy testing apparatus and method	March, 1992	Fishman et al.	128/743
5100427	Disposable lancet device	March, 1992	Crossman	606/182
5100428	Disposable two part body pricker	March, 1992	Mumford	606/182
5104380	Syringe with dose metering device	April, 1992	Holman	604/117
5104619	Disposable diagnostic system	April, 1992	Castro	422/56
5108564	Method and apparatus for amperometric diagnostic analysis	April, 1992	Szuminsky	204/153.12
5116759	Reservoir chemical sensors	May, 1992	Klainer	435/288
5120420	Biosensor and a process for preparation thereof	June, 1992	Nankai	204/403
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5126034	Bioelectrochemical electrodes	June, 1992	Carter	204/403
5128015	Method and apparatus for amperometric diagnostic analysis	July, 1992	Szuminsky	204/403
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5133730	Disposable-retractable finger stick device	July, 1992	Biro	606/182
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5201324	Disposable skin perforator and blood testing device	April, 1993	Swierczek	128/770
5205920	Enzyme sensor and method of manufacturing the same	April, 1993	Oyama	204/403
5212879	Method for manufacturing a disposable-retractable finger stick device	May, 1993	Biro	29/437
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5264103	Biosensor and a method for measuring a concentration of a substrate in a sample	November, 1993	Yoshioka	204/403
5264105	Enzyme electrodes	November, 1993	Gregg	204/403
5264106	Enhanced amperometric sensor	November, 1993	McAleer	204/403
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5282822	Lancet ejector for lancet injector	February, 1994	Macors	606/182
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5286364	Surface-modified electochemical biosensor	February, 1994	Yacynych	204/418
5288636	Enzyme electrode system	February, 1994	Pollman	435/288
5304192	Lancet with locking cover	April, 1994	Crouse	606/181
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5312590	Amperometric sensor for single and multicomponent analysis	May, 1994	Gunasingham	422/56
5314441	Disposable slicing lancet assembly	May, 1994	Cusack	606/182
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5350392	Lancing device with automatic cocking	September, 1994	Purcell	606/182
5354287	Injector for delivering fluid to internal target tissue	October, 1994	Wacks	604/232
5354447	Biosensor and method of quantitative analysis using the same	October, 1994	Uenoyama	204/403
5356420	Device for puncturing	October, 1994	Czernecki	606/182
5360410	Safety syringe for mixing two-component medicaments	November, 1994	Wacks	604/232
5366469	Lancet device for puncturing the skin	November, 1994	Steg	606/182
5366470	Lancet device	November, 1994	Ramel	606/183
5366609	Biosensing meter with pluggable memory key	November, 1994	White	204/403
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5378628	Sensor for measuring the amount of a component in solution	January, 1995	Graetzel	435/288
5382346	Biosensor and method of quantitative analysis using the same	January, 1995	Uenoyama	204/403
5383885	Blood collection and testing device	January, 1995	Bland	606/182
5389534	Biosensor containing a biochemical substance immobilized on a layer of an olefinic-unsaturated, epoxyfunctional polyether	February, 1995	Gentezkow	435/180
5393903	Mono, bis or tris(substituted 2,2'-bipyridine) iron, ruthenium, osmium or vanadium complexes and their methods of preparation	February, 1995	Graetzel	556/137
5395387	Lancet blade designed for reduced pain	March, 1995	Burns
5397334	Distal movement limiting assembly for finger stick device	March, 1995	Schenk	606/182
5401376	Electrochemical sensors	March, 1995	Foos	204/415
5402798	Disposable skin perforator and blood testing device	April, 1995	Swierczek	128/770
5407545	Method for measuring sample by enzyme electrodes	April, 1995	Hirose	204/153.12
5407554	Electrochemical sensor with multiple zones on a disc and its application to the quantitative analysis of glucose	April, 1995	Saurer	204/403
5407818	Biosensor containing a biochemical substance immobilized on a layer of olefinic-unsaturated, epoxy functional cross-linked polysiloxane	April, 1995	Gentezkow	435/180
5409583	Method for measuring concentrations of substrates in a sample liquid by using a biosensor	April, 1995	Yoshioka	204/153.12
5410059	Transition metal complexes having 2,2'-bipyridine ligands substituted by at least one ammonium alkyl radical	April, 1995	Fraser	546/10
5415169	Motorized mammographic biopsy apparatus	May, 1995	Siczek et al.	128/653.1
5423847	Safe lancet injector	June, 1995	Strong	606/182
5436161	Matrix coating for sensing surfaces capable of selective biomolecular interactions, to be used in biosensor systems	July, 1995	Bergstrom	435/291
5437999	Electrochemical sensor	August, 1995	Diebold	435/288
5443701	Electrobiochemical analytical method and electrodes	August, 1995	Willner	204/153
5445920	Fabrication process of biosensor	August, 1995	Saito	430/311
D362719	Combined lancet and flowered cap	September, 1995	Kaplan	D24/147
5454828	Lancet unit with safety sleeve	October, 1995	Schraga	606/181
5456875	Method for preparing plastic lancet	October, 1995	Lambert	264/328.1
5464418	Reusable lancet device	November, 1995	Schraga	606/182
5471102	Reciprocating shaft device	November, 1995	Becker	310/50
5472427	Trocar device	December, 1995	Rammler	604/164
5474084	Algesimeter with detachable pin wheel	December, 1995	Cunniff	128/744
5476474	Rotary lancet	December, 1995	Davis	606/182
5480387	Injection device	January, 1996	Gabriel	604/134
5487748	Blood sampling device	January, 1996	Marshall	606/182
5496453	Biosensor and method of quantitative analysis using the same	March, 1996	Uenoyama	205/777.5
5498542	Electrode mediators for regeneration of NADH and NADPH	March, 1996	Corey	435/283.1
5509410	Strip electrode including screen printing of a single layer	April, 1996	Hill	128/637
5510266	Method and apparatus of handling multiple sensors in a glucose monitoring instrument system	April, 1996	Bonner et al.
5512159	Biosensor	April, 1996	Yoshioka	204/403
5514152	Multiple segment encapsulated medical lancing device	May, 1996	Smith	606/182
5518006	Blood sampling device	May, 1996	Mawhirt	128/770
5524636	Method and apparatus for elasticity imaging	June, 1996	Sarvazyan	128/774
5525511	Electrochemical biosensor stability	June, 1996	D'Costa	435/287.9
5527333	Slicing disposable blood sampling device	June, 1996	Nikkels	606/182
5527334	Disposable, retractable lancet	June, 1996	Kanner	606/182
5529074	Uniform pressure diagnostic pinwheel	June, 1996	Greenfield	128/744
5540709	Lancet device	July, 1996	Ramel	606/183
5543326	Biosensor including chemically modified enzymes	August, 1996	Heller	435/287.9
5545174	Finger stick device	August, 1996	Schenk	606/182
5547702	Method for continuous manufacture of diagnostic test strips	August, 1996	Gleisner	427/2.13
5554166	Blood lancet device for withdrawing blood for diagnostic purposes	September, 1996	Lange	606/182
5558834	Device and method of seperating and assaying whole blood	September, 1996	Chu	422/55
5569286	Lancet assembly	October, 1996	Peckham	606/181
5569287	Means for collecting and spotting small amount of blood	October, 1996	Tezuka	606/182
5571132	Self activated finger lancet	November, 1996	Mawhirt	606/182
5575403	Dispensing instrument for fluid monitoring sensors	November, 1996	Charlton et al.	221/31
5575895	Biosensor and method for producing the same	November, 1996	Ikeda	204/403
5582697	Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same	December, 1996	Ikeda	204/403
5584846	Low cost disposable lancet	December, 1996	Mawhirt	606/181
5593852	Subcutaneous glucose electrode	January, 1997	Heller	435/14
5609749	Electrochemical assay method with novel p-phenylenediamine compound	March, 1997	Yamauchi	205/777.5
5613978	Adjustable tip for lancet device	March, 1997	Harding	606/181
5620279	Artificial water plant system for controlling sediment transport on a water bed	April, 1997	Genshaw	204/402
5624537	Biosensor and interface membrane	April, 1997	Turner	204/403
D379516	Lancet	May, 1997	Rutter	D24/146
5628764	Collar lancet device	May, 1997	Schraga	606/182
5628765	Lancet assembly	May, 1997	Susumu	606/182
5628890	Electrochemical sensor	May, 1997	Carter	204/403.5
5630986	Dispensing instrument for fluid monitoring sensors	May, 1997	Charlton et al.	422/64
5632410	Means of handling multiple sensors in a glucose monitoring instrument system	May, 1997	Moulton et al.	221/79
5643306	Disposable lancet	July, 1997	Schraga	606/182
5645555	Rotary lancet	July, 1997	Davis	606/182
5650062	Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same	July, 1997	Ikeda	205/778
5653863	Method for reducing bias in amperometric sensors	August, 1997	Genshaw	205/777.5
5657760	Apparatus and method for noninvasive doppler ultrasound-guided real-time control of tissue damage in thermal therapy	August, 1997	Ying et al.	128/660.03
5658444	Electrochemical sensors	August, 1997	Black	204/415
5662127	Self-contained blood withdrawal apparatus and method	September, 1997	De Vaughn	128/765
5662672	Single use, bi-directional linear motion lancet	September, 1997	Pambianchi	606/181
5680872	Simple blood-collecting device	October, 1997	Sesekura	128/760
5682884	Strip electrode with screen printing	November, 1997	Hill	128/637
5683562	Planar sensor for determining a chemical parameter of a sample	November, 1997	Schaffar	204/403
5695947	Amperometric cholesterol biosensor	December, 1997	Guo	435/11
5700695	Sample collection and manipulation method	December, 1997	Yassinzadeh et al.	436/180
5705045	Multi-biosensor for GPT and got activity	January, 1998	Park	204/403
5708247	Disposable glucose test strips, and methods and compositions for making same	January, 1998	McAleer	204/403
5709668	Automatic medicament injector employing non-coring needle	January, 1998	Wacks	604/232
5710011	Mediators to oxidoreductase enzymes	January, 1998	Forrow	435/25
5714390	Cartridge test system for the collection and testing of blood in a single step	February, 1998	Hallowitz et al.	436/526
5720862	Sensor and production method of and measurement method using the same	February, 1998	Hamamoto	204/403
5720924	Storage system for test elements	February, 1998	Eikmeier et al.	422/102
D392391	Disposable blood testing device	March, 1998	Douglas	D24/225
5723284	Control solution and method for testing the performance of an electrochemical device for determining the concentration of an analyte in blood	March, 1998	Ye	435/4
5727548	Strip electrode with screen printing	March, 1998	Hill	128/637
5730753	Assembly for adjusting pricking depth of lancet	March, 1998	Susumu	606/181
5733300	Single use, bi-directional linear motion lancet	March, 1998	Pambianchi	606/181
D393716	Lancet endcap	April, 1998	Brenneman	D24/147
D393717	Lancet endcap pointer	April, 1998	Brenneman	D24/147
5738244	Dispensing instrument for fluid monitoring sensors	April, 1998	Charlton et al.	221/26
5741634	Throwaway type chemical sensor	April, 1998	Nozoe	435/4
RE35803	Blood lancet device for and method withdrawing blood for diagnostic purposes	May, 1998	Lange	606/182
5746217	Interstitial fluid collection and constituent measurement	May, 1998	Erickson	128/760
5755733	Lancet assembly	May, 1998	Susumu	606/182
5758643	Method and apparatus for monitoring blood chemistry	June, 1998	Wong et al.	128/632
5759364	Electrochemical biosensor	June, 1998	Charlton	204/403
5762770	Electrochemical biosensor test strip	June, 1998	Pritchard	204/403
5770369	Nucleic acid mediated electron transfer	June, 1998	Meade	435/6
5772586	Method for monitoring the health of a patient	June, 1998	Heinonen	600/300
5772677	Incision device capable of automatic assembly and a method of assembly	June, 1998	Mawhirt	606/181
5773270	Three-layered membrane for use in an electrochemical sensor system	June, 1998	D'Orazio	435/177
5776157	Lancet apparatus and methods	July, 1998	Thorne et al.	606/182
5776719	Diagnostic compositions and devices utilizing same	July, 1998	Douglas	435/28
5782770	Hyperspectral imaging methods and apparatus for non-invasive diagnosis of tissue for cancer	July, 1998	Mooradian	600/476
5782852	Plastic incision blade	July, 1998	Foggia	606/182
5788651	Instrument and apparatus for biopsy	August, 1998	Weilandt	600/567
5788652	Blood sample collection device	August, 1998	Rahn	600/577
5795725	Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays	August, 1998	Buechler	435/7.1
5795774	Biosensor	August, 1998	Matsumoto	435/287.9
5797940	Adjustable skin incision device	August, 1998	Mawhirt	606/167
5797942	Re-usable end cap for re-usable lancet devices for removing and disposing of a contaminated lancet	August, 1998	Schraga	606/182
5798030	Biosensor membranes	August, 1998	Raguse	204/403
5798031	Electrochemical biosensor	August, 1998	Charlton	204/403
5800781	Blood sampling device	September, 1998	Gavin et al.	422/73
5801057	Microsampling device and method of construction	September, 1998	Smart et al.	436/68
5810199	Dispensing instrument for fluid monitoring sensor	September, 1998	Charlton et al.	221/31
5820551	Strip electrode with screen printing	October, 1998	Hill	600/347
5823973	Needle assembly for fluid sampler	October, 1998	Racchini et al.	600/573
5824491	Dry reagent test strip comprising benzidine dye precursor and antipyrine compound	October, 1998	Priest	435/28
5830219	Apparatus for holding and driving a surgical cutting device using stereotactic mammography guidance	November, 1998	Bird et al.	606/130
5840020	Monitoring method and a monitoring equipment	November, 1998	Heinonen	600/309
5840171	Electrochemical reactions	November, 1998	Birch	205/335
5846490	Automated test strip supplying system	December, 1998	Yokota et al.	422/66
5849174	Electrodes and their use in analysis	December, 1998	Sanghera	205/775
5854074	Dispensing instrument for fluid monitoring sensors	December, 1998	Charlton et al.	436/46
D403975	Test strip device	January, 1999	Douglas	D10/81
5855801	IC-processed microneedles	January, 1999	Lin et al.	216/2
5857983	Methods and apparatus for sampling body fluid	January, 1999	Douglas	600/538
5860922	Determining blood flow by measurement of temperature	January, 1999	Gordon et al.	600/431
5863800	Storage system for test elements	January, 1999	Eikmeier et al.	436/48
5866353	Electro chemical biosensor containing diazacyanine mediator for co-enzyme regeneration	February, 1999	Berneth	435/26
5868772	Blood sampling device with anti-twist lancet holder	February, 1999	LeVaughn	606/181
5869972	Testing device using a thermochromic display and method of using same	February, 1999	Birch	324/439
5871494	Reproducible lancing for sampling blood	February, 1999	Simons et al.	606/181
5872713	Synchronized analyte testing system	February, 1999	Douglas	702/85
5873887	Blood sampling device	February, 1999	King	606/182
5876957	Methods for applying a reagent to an analytical test device	March, 1999	Douglas	435/28
5879311	Body fluid sampling device and methods of use	March, 1999	Duchon et al.	600/583
5879373	System and method for the determination of tissue properties	March, 1999	Roeper	606/344
5880829	Apparatus for taking and analysing liquid samples, such as blood samples	March, 1999	Kauhaniemi et al.	356/246
5882494	Polyurethane/polyurea compositions containing silicone for biosensor membranes	March, 1999	Van Antwerp	204/403
5885211	Microporation of human skin for monitoring the concentration of an analyte	March, 1999	Eppstein et al.	600/309
5891053	Blood-collecting device	April, 1999	Sesekura	600/583
5900130	Method for sample injection in microchannel device	May, 1999	Benvegnu	204/453
5906921	Biosensor and method for quantitative measurement of a substrate using the same	May, 1999	Ikeda	435/25
D411619	Blood sampling lancet	June, 1999	Duchon	D24/146
5916156	Electrochemical sensors having improved selectivity and enhanced sensitivity	June, 1999	Hildenbrand	600/347
5916229	Rotating needle biopsy device and method	June, 1999	Evans	606/171
5916230	Blood sampling device with adjustable end cap	June, 1999	Brenneman	606/172
5921963	Skin piercing devices for medical use	July, 1999	Erez	604/192
5922188	Biosensor and method for quantitating biochemical substrate using the same	July, 1999	Ikeda	204/777.5
RE36268	Method and apparatus for amperometric diagnostic analysis	August, 1999	Szuminsky	205/777.5
5935075	Detecting thermal discrepancies in vessel walls	August, 1999	Casscells et al.	600/474
5938679	Apparatus and method for minimally invasive blood sampling	August, 1999	Freeman et al.	606/181
5951492	Methods and apparatus for sampling and analyzing body fluid	September, 1999	Douglas	600/583
5951582	Lancet apparatus and methods	September, 1999	Thorne et al.	606/182
5951836	Disposable glucose test strip and method and compositions for making same	September, 1999	McAleer	204/403
5954738	Blood sampling device with lancet damping system	September, 1999	LeVaughn	606/181
5958199	Biosensor	September, 1999	Miyamoto	204/403
5965380	Subcutaneous glucose electrode	October, 1999	Heller	435/14
5968063	Intramuscular stimulation therapy facilitating device and method	October, 1999	Chu et al.	606/185
5971941	Integrated system and method for sampling blood and analysis	October, 1999	Simons et al.	600/573
5972199	Electrochemical analyte sensors using thermostable peroxidase	October, 1999	Heller	205/777.5
5983193	Patient's nursing apparatus and nursing system	November, 1999	Heinonen	705/2
5985116	Biosensor	November, 1999	Ikeda	204/403
5993400	Apparatus and method for monitoring contact pressure between body parts and contact surfaces	November, 1999	Rincoe	600/595
5997561	Skin cutter for painless extraction of small blood amounts	December, 1999	Boecker	606/182
5997817	Electrochemical biosensor test strip	December, 1999	Crismore	422/58
5997818	Cassette for tonometric calibration	December, 1999	Hackner	422/681
6001067	Device and method for determining analyte levels	December, 1999	Shults	600/584
6020110	Production of electrodes for electrochemical sensing	February, 2000	Williams	430/315
6022324	Biopsy instrument	February, 2000	Skinner	600/566
6022366	Lancet having adjustable penetration depth	February, 2000	Schraga	606/181
6027459	Method and apparatus for obtaining blood for diagnostic tests	February, 2000	Shain et al.	600/573
6030399	Fluid jet blood sampling device and methods	February, 2000	Ignotz	606/167
6030827	Microfabricated aperture-based sensor	February, 2000	Davis	435/287
6033421	Tattoo machine	March, 2000	Theiss	606/186
6033866	Highly sensitive amperometric bi-mediator-based glucose biosensor	March, 2000	Guo	435/14
6036924	Cassette of lancet cartridges for sampling blood	March, 2000	Simons et al.	422/100
6048352	Disposable element for use in a body fluid sampling device	April, 2000	Douglas et al.	606/181
D424696	Glucose sensor	May, 2000	Ray	D24/169
6060327	Molecular wire injection sensors	May, 2000	Keen	436/518
6063039	Method and apparatus for obtaining blood for diagnostic tests	May, 2000	Cunningham	600/573
6066296	Sample addition, reagent application, and testing chamber	May, 2000	Brady	422/63
6067463	Method and apparatus for non-invasively measuring the amount of glucose in blood	May, 2000	Jeng	600/336
D426638	Glucose sensor buttons	June, 2000	Ray	D24/169
6071249	Method and apparatus for obtaining blood for diagnostic tests	June, 2000	Cunningham	600/578
6071250	Methods and apparatus for expressing body fluid from an incision	June, 2000	Douglas	600/583
6071251	Method and apparatus for obtaining blood for diagnostic tests	June, 2000	Cunningham	600/584
6071294	Lancet cartridge for sampling blood	June, 2000	Simons et al.	606/181
6074360	Electromagnetic transdermal injection device and methods related thereto	June, 2000	Hans-Peter	604/57
6077408	Biosensor and method of manufacturing the same	June, 2000	Miyamoto	204/403
6080172	Device for stabbing a corneum layer	June, 2000	Fujiwara	606/166
6083710	Electrochemical analyte measurement system	July, 2000	Heller	435/14
6086562	Disposable automatic injection device	July, 2000	Jacobsen	604/156
6090078	Dampening devices and methods for needle retracting safety vascular access devices	July, 2000	Erskine	604/198
6093156	Method and apparatus for obtaining blood for diagnostic tests	July, 2000	Cunningham et al.	600/573
6103033	Process for producing an electrochemical biosensor	August, 2000	Say	156/73.1
6107083	Optical oxidative enzyme-based sensors	August, 2000	Collins	435/288
6117630	Molecular detection apparatus and method	September, 2000	Reber et al.	435/4
6120462	Control method for an automated surgical biopsy device	September, 2000	Hibner et al.	600/566
6120676	Method of using a small volume in vitro analyte sensor	September, 2000	Heller	205/777.5
6121009	Electrochemical analyte measurement system	September, 2000	Heller	435/14
6129823	Low volume electrochemical sensor	October, 2000	Hughes	204/403.01
6132449	Extraction and transportation of blood for analysis	October, 2000	Lum et al.	606/181
6133837	Patient position system and method for a support surface	October, 2000	Riley	340/573.1
6134461	Electrochemical analyte	October, 2000	Say	600/345
6136013	Lancet device	October, 2000	Marshall et al.	606/167
6139562	Apparatus and method for incising	October, 2000	Mauze et al.	606/171
6143164	Small volume in vitro analyte sensor	November, 2000	Heller et al.	205/777.5
6152942	Vacuum assisted lancing device	November, 2000	Brenneman et al.	606/181
6153069	Apparatus for amperometric Diagnostic analysis	November, 2000	Pottgen	204/403
RE36991	Biosensor and method for producing the same	December, 2000	Yamamoto	204/403
6155992	Method and apparatus for obtaining interstitial fluid for diagnostic tests	December, 2000	Henning et al.	600/583
6156051	Lancet having adjustable penetration depth	December, 2000	Schraga	606/181
6157442	Micro optical fiber sensor device	December, 2000	Raskas	356/39
6159424	Apparatus for taking samples	December, 2000	Kauhaniemi et al.	422/63
6162611	Subcutaneous glucose electrode	December, 2000	Heller	435/14
6171325	Apparatus and method for incising	January, 2001	Mauze et al.	356/446
6175752	Analyte monitoring device and methods of use	January, 2001	Say	600/345
6176865	Apparatus and method for incising	January, 2001	Mauze et al.	606/171
6177000	Biosensor comprising a lipid membrane containing gated ion channels	January, 2001	Peterson	205/777.5
6183489	Disposable element for use in a body fluid sampling device	February, 2001	Douglas et al.	606/181
6190612	Oxygen sensing membranes and methods of making same	February, 2001	Berger	422/82.07
6191852	Optical measurement system for detecting luminescence or fluorescence signals	February, 2001	Paffhausen	356/244
6192891	Integrated system including medication delivery pen, blood monitoring device, and lancer	February, 2001	Gravel	128/920
6193673	Biopsy instrument driver apparatus	February, 2001	Viola et al.	600/568
6194900	Integrated miniaturized device for processing and NMR detection of liquid phase samples	February, 2001	Freeman	324/321
6197257	Micro sensor device	March, 2001	Raskas	422/82.05
6203504	Enhanced interstitial fluid collection	March, 2001	Latterell et al.	600/576
6206841	Method and apparatus for obtaining blood for diagnostic tests	March, 2001	Cunningham et al.
6210420	Apparatus and method for efficient blood sampling with lancet	April, 2001	Mauze et al.	606/182
6210421	Cutting device for skin for obtaining small blood samples in almost pain-free manner	April, 2001	Böcker et al.	606/182
6212417	Biosensor	April, 2001	Ikeda	204/403.14
6214804	Induction of a protective immune response in a mammal by injecting a DNA sequence	April, 2001	Felgner	514/44
6221238	Enzymatic-electrochemical one-shot affinity sensor for the quantitative determination of analytes for aqueous media and affinity assay	April, 2001	Grundig	205/777.5
6225078	Method for quantitative measurement of a substrate	May, 2001	Ikeda	435/25
6228100	Multi-use lancet device	May, 2001	Schraga	606/183
6230501	Ergonomic systems and methods providing intelligent adaptive surfaces and temperature control	May, 2001	Bailey	62/51.1
6231531	Apparatus and method for minimizing pain perception	May, 2001	Lum et al.	601/46
6241862	Disposable test strips with integrated reagent/blood separation layer	June, 2001	McAleer	204/403
6245060	Removal of stratum corneum by means of light	June, 2001	Loomis	606/9
6251260	Potentiometric sensors for analytic determination	June, 2001	Heller	205/777.5
6254831	Optical sensors with reflective materials	July, 2001	Barnard	422/82.08
6256533	Apparatus and method for using an intracutaneous microneedle array	July, 2001	Vuzhakov	604/21
6258229	Disposable sub-microliter volume sensor and method of making	July, 2001	Winarta	204/403
6258254	Biosensor	July, 2001	Miyamoto	205/777.5
6261241	Electrosurgical biopsy device and method	July, 2001	Burbank et al.	600/564
6261245	Body-fluid inspection device	July, 2001	Kawai et al.	600/576
6268161	Biosensor	July, 2001	Han	435/14
6270637	Electrochemical biosensor test strip	August, 2001	Crismore	204/403
6272359	Personal mobile communications device having multiple units	August, 2001	Kivela	455/567
6281006	Electrochemical affinity assay	August, 2001	Heller	435/287.9
6283926	Method and apparatus for obtaining blood for diagnostic tests	September, 2001	Cunningham et al.	600/573
6283982	Lancing device and method of sample collection	September, 2001	Levaughn	606/172
6284478	Subcutaneous glucose electrode	September, 2001	Heller	435/14
6285448	Clinical analyte determination by infrared spectroscopy	September, 2001	Kuenstner	356/39
6285454	Optics alignment and calibration system	September, 2001	Douglas et al.	356/446
6290683	Skin piercing needle assembly	September, 2001	Erez	604/273
6295506	Measurement apparatus	September, 2001	Heinonen	702/104
6299757	Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator	October, 2001	Feldman	205/775
6302855	Medical apparatus for use by a patient for medical self treatment of diabetes	October, 2001	Lav	600/584
6306104	Method and apparatus for obtaining blood for diagnostic tests	October, 2001	Cunningham et al.	600/573
6306152	Lancet device with skin movement control and ballistic preload	October, 2001	Verdonk et al.	606/182
6306347	Optical sensor and method of operation	October, 2001	Mason	422/58
6309535	Electrodes and their use in assays	October, 2001	Williams	205/777.5
6312612	Apparatus and method for manufacturing an intracutaneous microneedle array	November, 2001	Sherman	216/2
6315738	Assembly having lancet and means for collecting and detecting body fluid	November, 2001	Nishikawa et al.	600/583
6319210	Methods and apparatus for expressing body fluid from an incision	November, 2001	Douglas et al.	600/583
6322574	Disposable lancet	November, 2001	Lloyd	606/181
6331163	Protective coating for bodily sensor	December, 2001	Kaplan	600/486
6332871	Blood and interstitial fluid sampling device	December, 2001	Douglas et al.	600/583
6334363	Device for measuring pressure points to be applied by a compressive orthotic device	January, 2002	Testud	73/862
6334856	Microneedle devices and methods of manufacture and use thereof	January, 2002	Allen	604/191
6338790	Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator	January, 2002	Feldman	205/777.5
6350273	Corneum puncture needle	February, 2002	Minagawa	606/186
6350451	Immunotherapy of epithelial tumors using intralesional injection of antigens that induce a delayed type hypersensitivity reaction	February, 2002	Horn	424/184.1
6352514	Methods and apparatus for sampling and analyzing body fluid	March, 2002	Douglas et al.	600/583
6352523	Capacitance-based dose measurements in syringes	March, 2002	Brown	604/207
6353753	Optical imaging of deep anatomic structures	March, 2002	Flock	600/473
6364889	Electronic lancing device	April, 2002	Kheiri et al.	606/181
6364890	Extraction and transportation of blood for analysis	April, 2002	Lum et al.	606/181
6375627	Physiological fluid extraction with rapid analysis	April, 2002	Mauze et al.	600/584
6379301	Diabetes management system and method for controlling blood glucose	April, 2002	Worthington	600/309
6379317	Analytical measuring device with lancing device	April, 2002	Kintzig et al.	600/573
6379324	Intracutaneous microneedle array apparatus	April, 2002	Gartstein	604/22
6379969	Optical sensor for sensing multiple analytes	April, 2002	Mauze et al.	436/68
6387709	Method of operating an optical sensor adapted for selective analyte-sensing contact with a plurality of samples	May, 2002	Mason	436/164
6391005	Apparatus and method for penetration with shaft having a sensor for sensing penetration depth	May, 2002	Lum et al.	604/117
6399394	Testing multiple fluid samples with multiple biopolymer arrays	June, 2002	Dahm	436/180
6402701	Biopsy needle instrument	June, 2002	Kaplan et al.	600/567
6402704	Prothrombin test apparatus for home use	June, 2002	McMorrow	600/576
6409740	Blood lancet system for withdrawing blood for diagnostic purposes	June, 2002	Kuhr et al.	606/182
6413410	Electrochemical cell	July, 2002	Hodges	205/775
6413411	Method and apparatus for amperometric diagnostic analysis	July, 2002	Pottgen	205/777.5
6421633	Diabetes management	July, 2002	Heinonen	703/11
6428664	Biosensor	August, 2002	Bhullar	204/403.03
6436256	Electrodes for the measurement of analytes in small sample volumes	August, 2002	Williams	204/403.06
6436721	Device and method for obtaining clinically significant analyte ratios	August, 2002	Kuo	436/514
6440645	Production of microstructures for use in assays	August, 2002	Yon-Hin	430/322
6451040	Adjustable endcap for lancing device	September, 2002	Purcell	606/181
6458258	Biosensor	October, 2002	Taniike	204/403
6461496	Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator	October, 2002	Feldman et al.	205/777.5
6462162	Hydrophilic, swellable coatings for biosensors	October, 2002	van Antwerp et al.	528/77
6471903	Method for manufacturing an intracutaneous microneedle array	October, 2002	Sherman	264/328.1
6472220	Method of using cassette of lancet cartridges for sampling blood	October, 2002	Simons et al.	436/63
6475436	Method and device for removing consumable analytic products from a storage container	November, 2002	Schabbach	422/64
6484046	Electrochemical analyte sensor	November, 2002	Say	600/345
6485439	Apparatus for suctioning and pumping body fluid from an incision	November, 2002	Roe et al.	600/578
6485461	Disposable infusion device	November, 2002	Mason et al.	604/132
6745750	Fuel injection system for internal combustion engines	November, 2002	Han	435/14
6488891	Optical sensor and method of operation	December, 2002	Mason et al.	422/58
6491709	Alternate-site lancer	December, 2002	Sharma et al.	606/181
6497845	Storage container for analytical devices	December, 2002	Sacherer	422/104
6501404	System and method for encoding an input data stream by utilizing a predictive, look-ahead feature	December, 2002	Walker	341/143
6503210	Blood-collection position indicator	January, 2003	Hirao et al.	600/576
6503231	Microneedle device for transport of molecules across tissue	January, 2003	Praunsnitz	604/272
6506168	Apparatus and method for obtaining blood for diagnostic tests	January, 2003	Fathallah	600/578
6506575	Analytical element and method for the determination of an analyte in a liquid	January, 2003	Knappe et al.	435/25
6508795	Absorbent article with improved liquid acquisition capability	January, 2003	Eppstein	604/113
6514270	Single use lancet device	February, 2003	Schraga	606/182
6514460	Luminous glucose monitoring device	February, 2003	Fendrock	422/55
6519241	Mobile telephone for internet-applications	February, 2003	Theimer	370/338
6520326	Glucose sensor package system	February, 2003	McIvor	206/305
6527778	Tissue penetrating device and methods for using same	March, 2003	Athanasiou	606/80
6530892	Automatic skin puncturing system	March, 2003	Kelly	600/583
6530937	Adjustable tip for a lancet device and method	March, 2003	Schraga	606/182
6533949	Microneedle structure and production method therefor	March, 2003	Yeshurun	216/11
6537242	Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance	March, 2003	Palmer	604/22
6537292	Lancet having a blood-collecting needle with a safety feature	March, 2003	Lee	606/182
6540672	Medical system and a method of controlling the system for use by a patient for medical self treatment	April, 2003	Simonsen	600/300
6540675	Analyte monitor	April, 2003	Aceti	600/309
6540762	Device for perforating skin	April, 2003	Bertling	606/182
6540891	Test strip	April, 2003	Stewart	204/403.14
6547954	Biosensor and method for quantitating biochemical substrate using the same	April, 2003	Ikeda	205/777.5
6549796	Monitoring analyte concentration using minimally invasive devices	April, 2003	Sohrab	600/345
6551494	Small volume in vitro analyte sensor	April, 2003	Heller	205/777.5
6555061	Multi-layer reagent test strip	April, 2003	Leong	422/58
6558361	Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems	May, 2003	Yeshurun	604/272
6558402	Lancer	May, 2003	Chelak	606/182
6558528	Electrochemical test strip cards that include an integral dessicant	May, 2003	Matzinger	205/777.5
6561989	Thin lance and test sensor having same	May, 2003	Whitson	600/573
6565808	Line test device and methods of use	May, 2003	Hudak	422/58
6569157	Removal of stratum corneum by means of light	May, 2003	Shain	606/12
6571651	Method of preventing short sampling of a capillary or wicking fill device	June, 2003	Hodges	73/864.72
6572566	System for determining analyte concentrations in body fluids	June, 2003	Effenhauser	600/584
6574490	System for non-invasive measurement of glucose in humans	June, 2003	Abbink	600/316
6576101	Small volume in vitro analyte sensor	June, 2003	Heller	204/403.14
6576416	Analyte measurement device and method of use	June, 2003	Haviland	435/4
6587705	Biosensor, iontophoretic sampling system, and methods of use thereof	July, 2003	Kim et al.	600/347
6589260	System for withdrawing body fluid	July, 2003	Schmelzeisen-Redeker et al.	606/181
6589261	Lancet needle anchor and method	July, 2003	Abulhaj	606/181
6591125	Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator	July, 2003	Buse	600/347
6592745	Method of using a small volume in vitro analyte sensor with diffusible or non-leachable redox mediator	July, 2003	Feldman	205/777.5
6599407	Biosensor	July, 2003	Taniike	204/403.1
6599693	Array fabrication	July, 2003	Webb	435/4
6602205	Interstitial fluid collection and constituent measurement	August, 2003	Erickson	600/573
6602268	Blood lancet system for blood withdrawal for diagnostic purposes	August, 2003	Kuhr	606/181
6602678	Non- or minimally invasive monitoring methods	August, 2003	Kwon	435/14
6607658	Integrated lancing and measurement device and analyte measuring methods	August, 2003	Heller	205/777.5
6616616	Lancet system	September, 2003	Fritz	600/583
6616819	Small volume in vitro analyte sensor and methods	September, 2003	Liamos	204/403.02
6618934	Method of manufacturing small volume in vitro analyte sensor	September, 2003	Feldman	29/830
6620112	Disposable lancet combined with a reagent carrying strip and a system for extracting and analyzing blood in the body utilizing such a disposable lancet	September, 2003	Klitmose	600/583
6623501	Reusable ceramic skin-piercing device	September, 2003	Heller	606/181
6626851	Blood-collection position indicator	September, 2003	Hirao	600/576
6635222	Method of sterilizing products	October, 2003	Kent	422/22
6641533	Handheld personal data assistant (PDA) with a medical device and method of using the same	November, 2003	Causey	600/300
6645368	Meter and method of using the meter for determining the concentration of a component of a fluid	November, 2003	Beatty	205/792
6652720	Analytical instruments, biosensors and methods thereof	November, 2003	Mansouri	204/403.11
6656702	Biosensor containing glucose dehydrogenase	December, 2003	Yugawa	435/26
6659966	Fluid sampling apparatus	December, 2003	Essenpreis	600/583
6660018	Multiple lancet device	December, 2003	Lum et al.	606/181
6671527	Optical sensor for in situ measurement of analytes	December, 2003	Peterson	600/316
6679841	Fluid collection and monitoring device	January, 2004	Bojan	600/309
6679852	System for withdrawing body fluid	January, 2004	Schmelzeisen-Redeker et al.	600/583
6706000	Methods and apparatus for expressing body fluid from an incision	March, 2004	Perez	600/583
6706159	Combined lancet and electrochemical analyte-testing apparatus	March, 2004	Moerman	204/403.03
6706232	Biosensor	March, 2004	Hasegawa	264/403.09
6713660	Disposable article having a biosensor	March, 2004	Roe	604/361
6719887	Biosensor	April, 2004	Hasegawa	204/403.09
6719923	Paste, which can undergo screen printing for producing a porous polymer membrane for a biosensor	April, 2004	Stiene	252/511
6723111	Lancet needle anchor method	April, 2004	Abulhaj	606/181
6723371	Process for preparing an electrochemical test strip	April, 2004	Chih-hui	472/2.13
6723500	Test strips having reaction zones and channels defined by a thermally transferred hydrophobic barrier	April, 2004	Yu	435/4
6726818	Biosensors with porous chromatographic membranes	April, 2004	Cui et al.	204/403.01
6733493	Laser skin perforator	May, 2004	Gruzdev	606/9
6736777	Biosensor, iontophoretic sampling system, and methods of use thereof	May, 2004	Kim	600/365
6740215	Biosensor	May, 2004	Yamamoto	204/403.14
6743211	Devices and methods for enhanced microneedle penetration of biological barriers	June, 2004	Prausnitz	604/239
6749792	Micro-needles and methods of manufacture and use thereof	June, 2004	Olsen	264/328.1
6751491	Analyte measuring biosensor chip using image scanning system	June, 2004	Lew	600/345
6752817	Split pressure ring for lancing device and method of operation	June, 2004	Flora	606/181
6759190	Test strip for detection of analyte and methods of use	July, 2004	Lin	435/4
6764496	Single use lancet assembly	July, 2004	Schraga	606/182
6764581	Electrode with thin working layer	July, 2004	Forrow	204/403
6767441	Biosensor with peroxidase enzyme	July, 2004	Cai	204/403.03
6773671	Multichemistry measuring device and test strips	August, 2004	Lewis	422/58
6776888	Biosensor	August, 2004	Yamamoto	204/403.06
6780645	Diagnostic kit with a memory storing test strip calibration codes and related methods	August, 2004	Hayter	436/8
6780647	Sensor material, sensor and detection method for bio-substance	August, 2004	Fujiwara	436/169
6783502	Integrated lancing and analytic device	August, 2004	Orloff	600/583
6783537	Lancet dispenser	August, 2004	Kuhr	606/182
6784274	Hydrophilic, swellable coatings for biosensors	August, 2004	van Antwerp et al.	528/77
6786874	Apparatus and method for the collection of interstitial fluids	September, 2004	Grace	600/573
6787013	Biosensor	September, 2004	Chang	204/412
6787109	Test element analysis system	September, 2004	Haar	422/82.05
6790327	Device and method for determining the concentration of a substrate	September, 2004	Ikeda	204/403.1
6790599	Microfluidic devices and manufacture thereof	September, 2004	Madou	430/320
6792791	Inspection chip for sensor measuring instrument	September, 2004	Sato	73/1.02
6793632	Percutaneous biological fluid constituent sampling and measurement devices and methods	September, 2004	Sohrab	600/573
6793633	Blood and interstitial fluid sampling device	September, 2004	Douglas	600/583
6793802	Biosensors having improved sample application and measuring properties and uses thereof	September, 2004	Lee	205/777.5
6797150	Determination of sample volume adequacy in biosensor devices	September, 2004	Kermani	205/777.5
6800488	Methods of manufacturing reagent test strips	October, 2004	Khan et al.	436/166
6801041	Sensor having electrode for determining the rate of flow of a fluid	October, 2004	Karinka	324/444
6801804	Device and method for monitoring and controlling electrical resistance at a tissue site undergoing iontophoresis	October, 2004	Miller	604/20
6802199	Needle for body fluid tester	October, 2004	Hilgers	72/370.1
6802811	Sensing, interrogating, storing, telemetering and responding medical implants	October, 2004	Slepian	600/309
6802957	Self-referencing enzyme-based microsensor and method of use	October, 2004	Jung	205/777.5
6805780	Electrochemical biosensor test strip, fabrication method thereof and electrochemical biosensor	October, 2004	Ryu	204/403.01
6808499	Therapeutic and diagnostic needling device and method	October, 2004	Churchill et al.	600/587
6808908	Functionalized porous substrate for binding chemical and biological moieties	October, 2004	Yao	435/181
6808937	Displacement assay on a porous membrane	October, 2004	Ligler	436/518
6809807	Body fluid analyte measurement	October, 2004	Erickson	356/213
6811557	Adjustable length member such as a cap of a lancet device for adjusting penetration depth	November, 2004	Schraga	606/182
6811659	Microelectrogravimetrically plated biosensors and apparatus for producing same	November, 2004	Vachon	204/224
6811753	Blood testing tool	November, 2004	Hirao	422/101
6811792	Solid dose delivery vehicle and methods of making same	November, 2004	Roser	424/423
6812031	Regeneration of biosensors	November, 2004	Carlsson	436/52
6814843	Biosensor	November, 2004	Bhullar	204/403.01
6814844	Biosensor with code pattern	November, 2004	Bhullar	204/403.1
6814845	Method for depositing an enzyme on an electrically conductive substrate	November, 2004	Wilson	204/486
6815186	Implantable glucose sensor	November, 2004	Clark	435/183
6816742	Biosensor and methods of use thereof	November, 2004	Kim	600/345
6818180	Devices for testing for the presence and/or concentration of an analyte in a body fluid	November, 2004	Douglas	422/58
6821483	Reagents test strip with alignment notch	November, 2004	Phillips	422/58
6823750	Method of preventing short sampling of a capillary or wicking fill device	November, 2004	Hodges	73/864.72
6825047	Device and method for multiple analyte detection	November, 2004	Woudenberg	436/518
6827250	Methods for hermetically sealing microchip reservoir devices	December, 2004	Uhland	228/110.1
6827829	Test strip for a concentration measuring apparatus biosensor system	December, 2004	Kawanaka	204/403.02
6830551	Body fluid measuring instrument and body fluid sampler thereof	December, 2004	Uchigaki	600/584
6830668	Small volume electrochemical sensor	December, 2004	Musho	204/400
6830669	Biosensor	December, 2004	Miyazaki	204/409
6833540	System for measuring a biological parameter by means of photoacoustic interaction	December, 2004	MacKenzie	250/214
6835184	Method and device for abrading skin	December, 2004	Sage	604/46
6835553	Photometric glucose measurement system using glucose-sensitive hydrogel	December, 2004	Han	435/14
6837858	Method and apparatus for obtaining blood for diagnostic tests	January, 2005	Cunningham	600/573
6837976	Disposable sensor with enhanced sample port inlet	January, 2005	Cai	204/403.14
6837988	Biological fluid sampling and analyte measurement devices and methods	January, 2005	Leong	205/792
6840912	Consolidated body fluid testing device and method	January, 2005	Kloepfer	600/583
6841052	Electrochemical-sensor design	January, 2005	Musho	204/401
6843254	Sensor controlled analysis and therapeutic delivery system	January, 2005	Tapper	128/898
6847451	Apparatuses and methods for analyte concentration determination	January, 2005	Pugh	356/436
6489052	Fuel cell air purification subsystem	February, 2005	Uchigaki	600/584
6849168	Electrochemical microsensor package	February, 2005	Crumly	204/416
6849216	Method of making sensor	February, 2005	Rappin	264/134
6850790	Monitoring of physiological analytes	February, 2005	Berner	600/347
20010017269	Electrochemical analyte sensors using thermostable soybean peroxidase	August, 2001	Heller	205/777.5
20010027328	Multiple lancet device	October, 2001	Lum	606/186
20010031931	Method and apparatus for obtaining blood for diagnostic tests	October, 2001	Cunningham et al.	600/573
20010054319	Electrodes with multilayer membranes and methods of using and making the electrodes	December, 2001	Heller	73/849
20020002344	Methods and apparatus for sampling and analyzing body fluid	January, 2002	Douglas et al.	600/583
20020004196	Thin lance and test sensor having same	January, 2002	Whitson	435/4
20020025469	Biological fuel cell and methods	February, 2002	Heller	429/43
20020029058	Lancing device and method of sample collection	March, 2002	Levaughn	606/181
20020040230	Blood lancet system for blood withdrawal for diagnostic purposes	April, 2002	Kuhr	606/181
20020042090	Subcutaneous glucose electrode	April, 2002	Heller	435/14
20020044890	Test member	April, 2002	Black	422/56
20020052618	Analytical device with integrated lancet	May, 2002	Haar	606/181
20020053523	Small volume in vitro analyte sensor and methods	May, 2002	Liamos	205/787
20020057993	Test device	May, 2002	Maisey	422/82.01
20020076349	Test device	June, 2002	Aitken	422/58
20020078091	Automatic summarization of a document	June, 2002	Vu	707/513
20020081588	Multi-sensor array for electrochemical recognition of nucleotide sequences and methods	June, 2002	Lumley-Woodyear	435/6
20020082543	Microneedle devices and production thereof	June, 2002	Park et al.	604/21
20020084196	Small volume in vitro analyte sensor and methods	July, 2002	Liamos	205/792
20020087056	Analyte monitor	July, 2002	Aceti
20020092612	Rapid response glucose sensor	July, 2002	Davies	156/292
20020103499	Lancet device having capillary action	August, 2002	Perez et al.	606/182
20020120216	Lancet system	August, 2002	Fritz	600/583
20020130042	Combined lancet and electrochemical analyte-testing apparatus	September, 2002	Moerman	204/403.01
20020136667	Silicon nitride window for microsampling device and method of construction	September, 2002	Subramanian	422/100
20020136863	Silicon microlancet device and method of construction	September, 2002	Subramanian	428/156
20020137998	Silicon microprobe with integrated biosensor	September, 2002	Smart	600/347
20020148739	Small Volume in Vitro Analyte Sensor and Methods	October, 2002	Liamos	205/787
20020160520	Silicon nano-collection analytic device	October, 2002	Orloff	436/72
20020161289	Detector array for optical spectrographs	October, 2002	Hopkins	600/322
20020168290	Physiological sample collection devices and methods of using the same	November, 2002	Yuzhakov	422/56
20020176984	Silicon penetration device with increased fracture toughness and method of fabrication	November, 2002	Smart	428/336
20020177761	Integrated lancing and analytic device	November, 2002	Orloff	600/309
20020188224	Test media cassette for bodily fluid testing device	December, 2002	Roe	600/584
20030018282	System for withdrawing small amounts of body fluid	January, 2003	Effenhauser	600/583
20030018300	Body fluid sampling device	January, 2003	Duchon	604/164.01
20030028126	Blood withdrawal system	February, 2003	List	600/583
20030050573	Analytical device with lancet and test element	March, 2003	Kuhr	600/567
20030050656	Single use lancet device	March, 2003	Schraga	606/182
20030060730	Wicking methods and structures for use in sampling bodily fluids	March, 2003	Perez	600/576
20030073089	Companion cartridge for disposable diagnostic sensing platforms	April, 2003	Mauze	435/6
20030073229	Thermal regulation of fluidic samples within a diagnostic cartridge	April, 2003	Greenstein	435/287.2
20030073931	Universal diagnostic platform	April, 2003	Boecker	600/573
20030083685	Sampling module device and method	May, 2003	Freeman et al.
20030083686	Tissue penetration device	May, 2003	Freeman	606/181
20030088191	Blood sampling device with diaphragm actuated lancet	May, 2003	Freeman et al.	600/583
20030089730	Sensor dispensing device	May, 2003	May	221/232
20030093010	Fluid sampling apparatus	May, 2003	Essenpreis	600/583
20030100040	Blood analyte monitoring through subcutaneous measurement	May, 2003	Bonnecaze	435/14
20030106810	Electrochemical test device and related methods	June, 2003	Douglas	205/777.5
20030109777	Consolidated body fluid testing device and method	June, 2003	Kloepfer	600/367
20030111357	Test meter calibration	June, 2003	Black	205/775
20030113827	Non-or minimally invasive monitoring methods	June, 2003	Burkoth	435/14
20030116447	Electrodes, methods, apparatuses comprising micro-electrode arrays	June, 2003	Sturridge	205/777.5
20030135333	Analyte Monitor	July, 2003	Aceti	702/31
20030143113	PHYSIOLOGICAL SAMPLE COLLECTION DEVICES AND METHODS OF USING THE SAME	July, 2003	Yuzhakov	422/56
20030144608	Lancet-integrated sensor, measurer for lancet-integrated sensor, and catridge	July, 2003	Kojima	600/583
20030144609	Single use device for blood microsampling	July, 2003	Kennedy	600/583
20030146110	Electrochemical biosensor strip for analysis of liquid samples	August, 2003	Karinka	205/777.5
20030149348	Micro optical sensor device	August, 2003	Raskas	600/310
20030149377	Interstitial fluid collection and constituent measurement	August, 2003	Erickson	600/573
20030153900	Autonomous, ambulatory analyte monitor or drug delivery device	August, 2003	Aceti	604/890.1
20030191415	Integrated sample testing meter	October, 2003	Moerman	600/584
20030195435	Method and apparatus for collecting and transporting capillary blood samples for diagnostic and research evaluation	October, 2003	Williams	600/583
20030195540	Cap for a lancing device	October, 2003	Moerman	606/181
20030199744	Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator	October, 2003	Buse	600/347
20030199789	Method and apparatus for penetrating tissue	October, 2003	Boecker	600/575
20030199790	Method and apparatus for penetrating tissue	October, 2003	Boecker	600/576
20030199791	Method and apparatus for penetrating tissue	October, 2003	Boecker	600/576
20030199891	Lancet for blood extraction	October, 2003	Argauer	606/181
20030199893	Method and apparatus for a multi-use body fluid sampling device with analyte sensing	October, 2003	Boecker	606/181
20030199894	Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing	October, 2003	Boecker	606/181
20030199896	Method and apparatus for penetrating tissue	October, 2003	Boecker	606/181
20030199897	Method and apparatus for penetrating tissue	October, 2003	Boecker	606/181
20030199898	Method and apparatus for penetrating tissue	October, 2003	Boecker	606/181