Lanphere, Janel L. (Flagstaff, AZ, US)
Pierre, Ernest J. (Attleboro, MA, US)
Kapoglis, Greg (Attleboro, MA, US)
Casey II V, Thomas (Grafton, MA, US)

Plaque It!

10/637130

11/11/2008

08/08/2003

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Boston Scientific Scimed, Inc. (Maple Grove, MN, US)

424/501

424/493, 514/951, 428/402, 514/964, 424/489

B32B5/16; A61K9/14; A61K31/80; A61K31/745

424/501, 424/493, 428/403, 428/218, 428/212, 428/407, 514/951, 428/402, 514/964, 424/489

2275154	Method for making capsules	March, 1942	Merrill et al.
2609347	Method of making expanded polyvinyl alcohol-formaldehyde reaction product and product resulting therefrom	September, 1952	Wilson
3663470		May, 1972	Nishimura et al.
3737398		June, 1973	Yamaguchi
3957933	Apparatus for producing microspherical particles and method for operating such apparatus	May, 1976	Egli et al.
4025686	Molded composite article and method for making the article	May, 1977	Zion
4034759	Moisture-expandable prosthesis	July, 1977	Haerr
4055377	Magnetically orientable retroreflectorization particles	October, 1977	Erickson et al.
4076640	Preparation of spheroidized particles	February, 1978	Forgensi et al.
4094848	Process for producing finely divided porous polymer particles	June, 1978	Naito	521/72
4096230	Method of fabricating a moisture-expandable prosthesis	June, 1978	Haerr
4098728	Medical surgical sponge and method of making same	July, 1978	Rosenblatt
4110529	Method of manufacturing spherical polymer particles from polymer solutions	August, 1978	Stoy
4159719	Moisture-expandable ear wick	July, 1979	Haerr
4191672	Polymer aggregates	March, 1980	Salome et al.
4198318	Production of high strength alumina spheres by hydrogelling corresponding slurries	April, 1980	Stowell et al.
4243794	Mixture of rough and spheroidized resin particles	January, 1981	White et al.
4246208	Dust-free plasma spheroidization	January, 1981	Dundas
4266030	Macroporous polymeric carrier for covalently binding proteins, its preparation and its use for fixing active proteins	May, 1981	Tschang et al.
4268495	Injectable embolization and occlusion solution	May, 1981	Muxfeldt et al.
4271281	Process for preparing styrenic polymer particles	June, 1981	Kelley et al.
4402319	Releasable balloon catheter	September, 1983	Handa et al.
4413070	Polyacrolein microspheres	November, 1983	Rembaum
4427794	Process for the preparation of bead polymers of uniform particle size by polymerization of microencapsulated monomer	January, 1984	Lange et al.
4428869	Cologne consisting of microcapsule suspension	January, 1984	Munteanu et al.
4429062	Pharmaceutically acceptable silicon rubber and therapeutical set and the use thereof for surgical embolization	January, 1984	Pasztor et al.
4442843	Microbubble precursors and methods for their production and use	April, 1984	Rasor et al.
4444961	Process and apparatus for preparing uniform size polymer beads	April, 1984	Timm
4452773	Magnetic iron-dextran microspheres	June, 1984	Molday
4456693	Hydrocracking catalyst	June, 1984	Welsh
4459145	Fabrication of glass microspheres with conducting surfaces	July, 1984	Elsholz
4472552	Continuous process for making solid, free-flowing water dispersible PVA-aldehyde reaction product	September, 1984	Blouin
4477255	Pharmaceutically acceptable silicon rubber and therapeutical set and the use thereof for surgical embolization	October, 1984	Pasztor et al.
4492720	Method of preparing microspheres for intravascular delivery	January, 1985	Moiser
4522953	Low density porous cross-linked polymeric materials and their preparation and use as carriers for included liquids	June, 1985	Barby et al.
4542178	Plasticizer-containing polyvinyl alcohol granules	September, 1985	Zimmermann et al.
4551132	Pharmaceutically acceptable silicon rubber and therapeutical set and the use thereof for surgical embolization	November, 1985	Pasztor et al.
4551436	Fabrication of small dense silicon carbide spheres	November, 1985	Johnson et al.
4573967	Vacuum vial infusion system	March, 1986	Hargrove et al.
4622362	Polyacrolein microspheres	November, 1986	Rembaum
4623706	Process for preparing uniformly sized polymer particles by suspension polymerization of vibratorily excited monomers in a gaseous or liquid stream	November, 1986	Timm et al.
4640807	Process for the preparation of silica spheres	February, 1987	Afghan et al.
4657756	Microbubble precursors and apparatus for their production and use	April, 1987	Rasor et al.
4661137	Process for producing glass microspheres	April, 1987	Garnier et al.
4663358	Porous and transparent poly(vinyl alcohol) gel and method of manufacturing the same	May, 1987	Hyon et al.
4671954	Microspheres for incorporation of therapeutic substances and methods of preparation thereof	June, 1987	Goldberg et al.
4674480	Drug compositions and methods of applying same	June, 1987	Lemelson
4675113	Affinity chromatography using dried calcium alginate-magnetite separation media in a magnetically stabilized fluidized bed	June, 1987	Graves et al.
4678710	Coated particulate materials and method for manufacture thereof	July, 1987	Sakimoto et al.
4678814	Polyacrolein microspheres	July, 1987	Rembaum
4680320	Method for preparation of droplets	July, 1987	Uku et al.
4681119	Method of production and use of microbubble precursors	July, 1987	Rasor et al.
4695466	Multiple soft capsules and production thereof	September, 1987	Morishita et al.
4713076	Coating composition and anchorage component for surgical implants	December, 1987	Draenert
4742086	Process for manufacturing porous polymer	May, 1988	Masamizu et al.	521/62
4743507	Nonspherical microparticles and method therefor	May, 1988	Franses et al.
4772635	Bead-shaped crosslinked copolymers containing epoxide groups and basic amino groups, a process for their preparation and their use	September, 1988	Mitschker et al.
4782097	Process for the preparation of hollow microspheres	November, 1988	Jain et al.
4789501	Glass microspheres	December, 1988	Day et al.
4793980	Hollow porous microspheres as substrates and containers for catalyst	December, 1988	Torobin
4795741	Compositions for therapeutic percutaneous embolization and the use thereof	January, 1989	Leshchiner et al.
4801458	Sustained release pharmaceutical plaster	January, 1989	Hidaka et al.
4804366	Cartridge and adapter for introducing a beneficial agent into an intravenous delivery system	February, 1989	Zdeb et al.
4819637	System for artificial vessel embolization and devices for use therewith	April, 1989	Dormandy, Jr. et al.
4822535	Method for producing small, spherical polymer particles	April, 1989	Ekman et al.
4833237	Process for producing granular porous chitosan	May, 1989	Kawamura et al.
4850978	Drug delivery cartridge with protective cover	July, 1989	Dudar et al.
4859711	Hollow microspheres	August, 1989	Jain et al.
4863972	Porous cross-linked polyvinyl alcohol particles, process for producing the same, and separating agent composed of the same	September, 1989	Itagaki et al.
4897255	Metal radionuclide labeled proteins for diagnosis and therapy	January, 1990	Fritzberg et al.
4929400	Production of monodisperse, polymeric microspheres	May, 1990	Rembaum et al.
4933372	Porous rigid resins and process of preparation	June, 1990	Feibush et al.
4946899	Thermoplastic elastomers of isobutylene and process of preparation	August, 1990	Kennedy et al.
4954399	Porous polymer particles and preparation method thereof	September, 1990	Tani et al.	428/402
4981625	Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops	January, 1991	Rhim et al.
4990340	Sustained release pharmaceutical preparation	February, 1991	Hidaka et al.
4999188	Methods for embolization of blood vessels	March, 1991	Sloldovnik et al.
5007940	Injectable polymeric bodies	April, 1991	Berg
5011677	Radioactive glass microspheres	April, 1991	Day et al.
H000915	Controlled macroporous copolymer properties by removal of impurities in the diluent	May, 1991	Gibbs
5015423	Method of making uniform polymer particles	May, 1991	Eguchi et al.	264/9
5032117	Tandem syringe	July, 1991	Motta
5034324	Microorganism immobilized in a gel prepared from polyvinyl alcohol and a polysaccharide	July, 1991	Shinozaki et al.
5047438	Porous rigid resins and process of preparation	September, 1991	Feibush et al.
5079274	Process for preparing absorptive porous resin beads	January, 1992	Schneider et al.
5091205	Hydrophilic lubricious coatings	February, 1992	Fan
5106903	Preparation of large particle size monodisperse latexes	April, 1992	Vanderhoff et al.
5114421	Medicament container/dispenser assembly	May, 1992	Polak
5116387	Preparation of injectable polymeric bodies	May, 1992	Berg
5120349	Microcapsule having temperature-dependent permeability profile	June, 1992	Stewart et al.
5125892	Dispenser for storing and mixing several components	June, 1992	Drudik
5147631	Porous inorganic ultrasound contrast agents	September, 1992	Glajch et al.
5147937	Process for making controlled, uniform-sized particles in the 1 to 50 micrometer range	September, 1992	Frazza et al.
5149543	Ionically cross-linked polymeric microcapsules	September, 1992	Cohen et al.
5158573	Injectable polymeric bodies	October, 1992	Berg
5171214	Drug storage and delivery system	December, 1992	Kolber et al.
5171217	Method for delivery of smooth muscle cell inhibitors	December, 1992	March et al.
5181921	Detachable balloon with two self-sealing valves	January, 1993	Makita et al.
5190760	Solid pharmaceutical composition	March, 1993	Baker
5190766	Method of controlling drug release by resonant sound wave	March, 1993	Ishihara
5192301	Closing plug of a defect for medical use and a closing plug device utilizing it	March, 1993	Kamiya et al.
5202352	Intravascular embolizing agent containing angiogenesis-inhibiting substance	April, 1993	Okada et al.
5216096	Process for the preparation of cross-linked polymer particles	June, 1993	Hattori et al.
5253991	Apparatus for producing spheroidal inorganic particulate material	October, 1993	Yokota et al.
5260002	Method and apparatus for producing uniform polymeric spheres	November, 1993	Wang
5262176	Synthesis of polysaccharide covered superparamagnetic oxide colloids	November, 1993	Palmacci et al.
5263992	Biocompatible device with covalently bonded biocompatible agent	November, 1993	Guire
5288763	Porous, polymer beads and process of their preparation	February, 1994	Li et al.
5292814	Process for the preparation of monodispersed polymer beads	March, 1994	Bayer et al.
5302369	Microspheres for radiation therapy	April, 1994	Day et al.
5314974	Method for producing a spherical acrylonitrile crosslinked copolymer	May, 1994	Ito et al.
5316774	Blocked polymeric particles having internal pore networks for delivering active substances to selected environments	May, 1994	Eury et al.
RE34640	Thermoplastic elastomers of isobutylene and process of preparation	June, 1994	Kennedy et al.
5320639	Vascular plug delivery system	June, 1994	Rudnick
5328936	Polymerization process for making porous polymeric particles	July, 1994	Leifholtz et al.	521/65
5336263	Treatment of urological and gastric fluid reflux disorders by injection of mmicro particles	August, 1994	Ersek et al.
5344452	Alloplastic implant	September, 1994	Lemperle
5344867	Vinylidene chloride emulsion interpolymer composition	September, 1994	Morgan et al.
5354290	Porous structure of an absorbent polymer	October, 1994	Gross
5369133	Method for preparing an improved porous polymer bead	November, 1994	Ihm et al.
5369163	Process for preparing large dimension emulsion polymer particles, polymer product and uses thereof	November, 1994	Chiou et al.
5382260	Embolization device and apparatus including an introducer cartridge and method for delivering the same	January, 1995	Dormandy, Jr. et al.
5384124	Solid porous unitary form comprising micro-particles and/or nano-particles, and its preparation	January, 1995	Courteille et al.
5397303	Liquid delivery device having a vial attachment or adapter incorporated therein	March, 1995	Sancoff et al.
5398851	Liquid delivery device	March, 1995	Sancoff et al.
5403870	Process for forming a porous particle of an absorbent polymer	April, 1995	Gross
5417982	Controlled release of drugs or hormones in biodegradable polymer microspheres	May, 1995	Modi
5431174	Method of fluid delivery and collection	July, 1995	Knute
5435645	Process and apparatus for the mixing and direct emplacement of a two-component bone cement	July, 1995	Faccioli et al.
5443495	Polymerization angioplasty balloon implant device	August, 1995	Buscemi et al.
5456693	Embolization plugs for blood vessels	October, 1995	Conston et al.
5468801	Dual stabilized microparticles	November, 1995	Antonelli et al.
5469854	Methods of preparing gas-filled liposomes	November, 1995	Unger et al.
5476472	Embolization device and apparatus including an introducer cartridge and a delivery catheter and method for delivering the embolization device	December, 1995	Dormandy, Jr. et al.
5484584	Therapeutic and diagnostic use of modified polymeric microcapsules	January, 1996	Wallace et al.
5490984	Use of injectable biomaterials for the repair and augmentation of the anal sphincters	February, 1996	Freed
5494682	Ionically cross-linked polymeric microcapsules	February, 1996	Cohen et al.
5494940	Low density materials having high surface areas and articles formed therefrom	February, 1996	Unger et al.
5512604	Porous copolymers having a cellular polymeric structure suitable for preparing ion-exchange resins and adsorbents	April, 1996	Demopolis
5514090	Closed drug delivery system	May, 1996	Kriesel et al.
5525334	Method for vascular embolization	June, 1996	Ito et al.
5534589	Repulpable plastic films	July, 1996	Hager et al.
5541031	Polymer particles and toner for electrophotography using the polymer particles	July, 1996	Yamashita et al.
5542935	Therapeutic delivery systems related applications	August, 1996	Unger et al.
5553741	Liquid delivery device	September, 1996	Sancoff et al.
5556610	Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method	September, 1996	Yan et al.
5556931	Polymerizable composition and organic glass	September, 1996	Cercone et al.
5558255	Liquid delivery device	September, 1996	Sancoff et al.
5558822	Method for production of spheroidized particles	September, 1996	Gitman et al.
5558856	Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging	September, 1996	Klaveness et al.
5559266	Iodinated esters	September, 1996	Klaveness et al.
5567415	Ultrasound contrast agents and methods for their manufacture and use	October, 1996	Porter
5569193	Syringe system accommodating separately storable prefilled containers for two constituents	October, 1996	Hofstetter et al.
5569449	Gaseous microparticles as ultrasound contrast agents	October, 1996	Klaveness et al.
5569468	Vaccine delivery system for immunization, using biodegradable polymer microspheres	October, 1996	Modi
5571182	Textured micro implants	November, 1996	Ersek et al.
5580575	Therapeutic drug delivery systems	December, 1996	Unger et al.
5583162	Polymeric microbeads and method of preparation	December, 1996	Li et al.
5585112	Method of preparing gas and gaseous precursor-filled microspheres	December, 1996	Unger et al.
5595821	Repulpable plastic films	January, 1997	Hager et al.
5622657	Prolonged release microparticle preparation and production of the same	April, 1997	Takada et al.
5624685	High polymer gel and vascular lesion embolizing material comprising the same	April, 1997	Takahashi et al.
5635215	Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same	June, 1997	Boschetti et al.
5637087	Prefilled, two-constituent syringe	June, 1997	O'Neil et al.
5639710	Solid microspheres for agriculturally active compounds and process for their production	June, 1997	Lo et al.
5648095	Preparation of microparticles	July, 1997	Illum et al.
5648100	Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same	July, 1997	Boschetti et al.
5650116	Method of making a medical device from ironically crosslinked polymer	July, 1997	Thompson
5651990	Prolonged release microparticle preparation and production of the same	July, 1997	Takada et al.
5653922	Polymeric microbeads and method of preparation	August, 1997	Li et al.
5657756	Method and systems for obtaining higher order gradiometer measurements with lower order gradiometers	August, 1997	Vrba
5681576	Method and composition for post surgical adhesion reduction	October, 1997	Henry
5695480	Embolizing compositions	December, 1997	Evans et al.
5695740	Perfluorocarbon ultrasound contrast agent comprising microbubbles containing a filmogenic protein and a saccharide	December, 1997	Porter
5698271	Methods for the manufacture of magnetically responsive particles	December, 1997	Liberti et al.
5701899	Perfluorobutane ultrasound contrast agent and methods for its manufacture and use	December, 1997	Porter
5715824	Methods of preparing gas-filled liposomes	February, 1998	Unger et al.
5716981	Anti-angiogenic compositions and methods of use	February, 1998	Hunter et al.
5718884	Microbubble-based contrast agents with crosslinked and reduced proteinaceous shells	February, 1998	Klaveness et al.
5723269	Microparticle preparation and production thereof	March, 1998	Akagi et al.
5725534	Method of manufacturing an assembly for positioning an embolization coil in the vascular system, and such an assembly	March, 1998	Rasmussen
5733925	Therapeutic inhibitor of vascular smooth muscle cells	March, 1998	Kunz et al.
5741331	Biostable elastomeric polymers having quaternary carbons	April, 1998	Pinchuk
5746734	Introducer cartridge for delivering an embolization device	May, 1998	Dormandy, Jr. et al.
5752974	Injectable or implantable biomaterials for filling or blocking lumens and voids of the body	May, 1998	Rhee et al.
5756127	Implantable bioresorbable string of calcium sulfate beads	May, 1998	Grisoni et al.
5760097	Methods of preparing polymeric microbeds	June, 1998	Li et al.
5766147	Vial adaptor for a liquid delivery device	June, 1998	Sancoff et al.
5770222	Therapeutic drug delivery systems	June, 1998	Unger et al.
5779668	Syringe barrel for lyophilization, reconstitution and administration	July, 1998	Grabenkort
5785642	Methods for treating urinary incontinence in mammals	July, 1998	Wallace et al.
5785682	Pre-filled syringe drug delivery system	July, 1998	Grabenkort
5792478	Tissue injectable composition and method of use	August, 1998	Lawin et al.
5795562	Contrast agents comprising gas-containing or gas-generating microparticles or microballoons	August, 1998	Klaveness et al.
5797953	Helical embolization coil	August, 1998	Tekulve
5807323	Mixing and delivery syringe assembly	September, 1998	Kriesel et al.
5813411	Method of deforming tissue with a swollen hydrogel	September, 1998	Van Bladel et al.
5823198	Method and apparatus for intravasculer embolization	October, 1998	Jones et al.
5827502	Microparticulate microbubble-generating contrast agents	October, 1998	Klaveness et al.
5827531	Microcapsules and methods for making	October, 1998	Morrison et al.
5830178	Methods for embolizing vascular sites with an emboilizing composition comprising dimethylsulfoxide	November, 1998	Jones et al.
5833361	Apparatus for the production of small spherical granules	November, 1998	Funk
5840387	Sulfonated multiblock copolymer and uses therefor	November, 1998	Berlowitz-Tarrant et al.
5846518	Gas mixtures useful as ultrasound contrast media contrast agents containing the media and method	December, 1998	Yan et al.
5853752	Methods of preparing gas and gaseous precursor-filled microspheres	December, 1998	Unger et al.
5855615	Controller expansion sphincter augmentation media	January, 1999	Bley et al.
5863957	Polymeric microbeads	January, 1999	Li et al.
5876372	Syringe system accomodating seperate prefilled barrels for two constituents	March, 1999	Grabenkort et al.
5877224	Polymeric drug formulations	March, 1999	Brocchini et al.
5885216	Total system for contrast delivery	March, 1999	Evans, III et al.
5885547	Particulate material	March, 1999	Gray
5888546	Embolic material for endovascular occlusion of abnormal vasculature and method for using the same	March, 1999	Ji et al.
5888930	Asymmetric microporous beads for controlled release	March, 1999	Smith et al.	504/359
5891155	Embolizing system	April, 1999	Irie
5894022	Embolic material for endovascular occlusion of abnormal vasculature and method of using the same	April, 1999	Ji et al.
5895398	Method of using a clot capture coil	April, 1999	Wensel et al.
5895411	Embolizing system	April, 1999	Irie
5899877	One-piece dispensing device for the contamination-free administration of medicaments (cytostatica)	May, 1999	Leibitzki et al.
5902832	Method of synthesizing swollen hydrogel for sphincter augmentation	May, 1999	Van Bladel et al.
5902834	Method of manufacturing particles, and particles that can be produced in accordance with the method	May, 1999	Porrvik	521/62
5922025	Soft tissue augmentation material	July, 1999	Hubbard
5922304	Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents	July, 1999	Unger
5928626	Contrast agents, consisting of carbohydrate particles	July, 1999	Klaveness et al.
5935553	Methods of preparing gas-filled liposomes	August, 1999	Unger et al.
5951160	Method and apparatus for packaging, mixing and delivering bone cement	September, 1999	Ronk
5957848	Preparation of further diagnostic agents	September, 1999	Sutton et al.
5959073	Method for preparing polymeric beads	September, 1999	Schlameus et al.
6003566	Vial transferset and method	December, 1999	Thibault et al.
6015546	Preparation of further diagnostic agents	January, 2000	Sutton et al.
6027472	Mixing and delivery syringe assembly	February, 2000	Kriesel et al.
6028066	Prodrugs comprising fluorinated amphiphiles	February, 2000	Unger
6047861	Two component fluid dispenser	April, 2000	Vidal et al.
6048908	Hydrophilic polymeric material	April, 2000	Kitagawa
6051247	Moldable bioactive compositions	April, 2000	Hench et al.
6056721	Balloon catheter and method	May, 2000	Shulze
6056844	Temperature-controlled induction heating of polymeric materials	May, 2000	Guiles et al.
6059766	Gynecologic embolotherapy methods	May, 2000	Greff
6063068	Vial connecting device for a sliding reconstitution device with seal	May, 2000	Fowles et al.
6071495	Targeted gas and gaseous precursor-filled liposomes	June, 2000	Unger et al.
6071497	Microparticles for lung delivery comprising diketopiperazine	June, 2000	Steiner et al.
6073759	Pre-filled package containing unit dose of medical gas and method of making same	June, 2000	Lamborne et al.
6090925	Macromolecular microparticles and methods of production and use	July, 2000	Woiszwillo et al.
6096344	Bioerodible porous compositions	August, 2000	Liu et al.
6099064	Windshield visor for motor vehicles	August, 2000	Lund
6099864	In situ activation of microcapsules	August, 2000	Morrison et al.
6100306	Polymeric microbeads and methods of preparation	August, 2000	Li et al.
6139963	Polyvinyl alcohol hydrogel and process for producing the same	October, 2000	Fujii et al.
6149623	Delivery system for pharmaceuticals packed in pharmaceutical vials	November, 2000	Reynolds
6160084	Biodegradable shape memory polymers	December, 2000	Langer et al.
6162377	Apparatus and method for the formation of uniform spherical particles	December, 2000	Ghosh et al.
6165193	Vascular embolization with an expansible implant	December, 2000	Greene, Jr. et al.
6179817	Hybrid coating for medical devices	January, 2001	Zhong
6191193	Microspheric embolic materials having a dual structure of poly(vinyl acetate) core and poly(vinyl alcohol) shell and method for preparing the same	February, 2001	Lee et al.	523/201
6214331	Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained	April, 2001	Vanderhoff et al.
6214384	Nanosheres comprising a biocompatible polysaccharide	April, 2001	Pallado et al.
6224630	Implantable tissue repair device	May, 2001	Bao et al.
6224794	Methods for microsphere production	May, 2001	Amsden et al.
6235224	Process for preparing microparticles through phase inversion phenomena	May, 2001	Mathiowitz et al.
6238403	Filamentous embolic device with expansible elements	May, 2001	Greene, Jr. et al.
6245090	Transcatheter occluding implant	June, 2001	Gilson et al.
6251661	Seamless capsule for synthesizing biopolymer and method for producing the same	June, 2001	Urabe et al.
6258338	Hollow or cup-shaped microparticles and methods of use	July, 2001	Gray
6261585	Generating blood vessels with angiogenic material containing a biocompatible polymer and polymerizable compound	July, 2001	Sefton et al.
6264861	Method for producing rounded polymeric particles	July, 2001	Tavernier et al.
6267154	System for storing mixing and administering a drug	July, 2001	Felicelli et al.
6268053	Macromolecular microparticles and methods of production and use	July, 2001	Woiszwillo et al.
6277392	Tissue injectable composition	August, 2001	Klein
6280457	Polymer covered vaso-occlusive devices and methods of producing such devices	August, 2001	Wallace et al.
6291605	Polymerization process with spraying step	September, 2001	Freeman et al.
6296604	Methods of and compositions for treating vascular defects	October, 2001	Garibaldi et al.
6296622	Endoluminal device delivery system using axially recovering shape memory material	October, 2001	Kurz et al.
6296632	Ball-shaped fiber implant, and method and device for inserting the implant	October, 2001	Luscher et al.
6306418	Controlled expansion sphincter augmentation media	October, 2001	Bley
6306419	Medical uses of styrene sulfonate polymers	October, 2001	Vachon et al.
6306425	Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol	October, 2001	Tice et al.
6306427	Pellets containing active ingredients protected against degradation in the rumen of ruminants	October, 2001	Annonier et al.
6312407	Occlusion of a vessel	November, 2001	Zadno-Azizi et al.
6312942	Apparatus for encapsulating substances in small spherical particles formed from an encapsulating fluid	November, 2001	Plüss-Wenzinger et al.
6315709	Magnetic vascular defect treatment system	November, 2001	Garibaldi et al.
6335384	Methods for embolizing blood vessels	January, 2002	Evans et al.
6344182	Preparation of diagnostic agents by spray drying	February, 2002	Sutton et al.
6355275	Embolization using carbon coated microparticles	March, 2002	Klein
6368658	Coating medical devices using air suspension	April, 2002	Schwarz et al.
6379373	Methods and apparatus for intraluminal deposition of hydrogels	April, 2002	Sawhney et al.
6388043	Shape memory polymers	May, 2002	Langer et al.
6394965	Tissue marking using biocompatible microparticles	May, 2002	Klein
6423332	Method and composition for deforming soft tissues	July, 2002	Huxel et al.
6432437	Soft tissue augmentation material	August, 2002	Hubbard
6436112	Method of using a clot capture coil	August, 2002	Wensel et al.
6443941	Biodegradable polymeric endoluminal sealing process, apparatus and polymeric products for use therein	September, 2002	Slepian et al.
6458296	Method and device for capsulating microbial, plant and animal cells or biological and chemical substances	October, 2002	Heinzen et al.
6476069	Compositions for creating embolic agents and uses thereof	November, 2002	Krall et al.
6495155	Injectable opioid partial agonist or opioid antagonist microparticle compositions and their use in reducing consumption of abused substances	December, 2002	Tice et al.
6544503	Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained	April, 2003	Vanderhoff et al.
6544544	Anti-angiogenic compositions and methods of use	April, 2003	Hunter et al.
6545097	Drug delivery compositions and medical devices containing block copolymer	April, 2003	Pinchuk et al.
6575896	Method for treating tissue and apparatus for use therewith	June, 2003	Silverman et al.
6602261	Filamentous embolic device with expansile elements	August, 2003	Greene, Jr. et al.
6602524	Microspheres for use in the treatment of cancer	August, 2003	Batich et al.
6605111	Endovascular thin film devices and methods for treating and preventing stroke	August, 2003	Bose et al.
6629947	Systems and methods for delivering flowable substances for use as implants and surgical sealants	October, 2003	Sahatjian et al.
6632531	Porous particles, their aqueous dispersions, and method of preparation	October, 2003	Blankenship	428/402
6652883	Tissue bulking and coating compositions	November, 2003	Goupil et al.	424/489
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EP0706376	April, 1996			ANTI-ANGIOGENIC COMPOSITIONS AND METHODS OF USE
EP0730847	September, 1996			Controlled expansion sphincter augmentation media
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JP2002017848	January, 2002			INTRAVITALLY INJECTABLE PARTICULATE AND METHOD FOR PREPARING THE SAME
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WO/1998/026737	June, 1998			CONTRACEPTIVE SYSTEM AND METHOD OF USE
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WO/1999/000187	January, 1999			HYDROPHILIC POLYMERIC MATERIAL AND METHOD OF PREPARATION
WO/1999/012577	March, 1999			POLYMER PARTICLES MADE OF POLYVINYL ALCOHOL AND COMPRISING A CONTRAST AGENT FOR CHEMOEMBOLIZATION
WO/1999/043380	September, 1999			GYNECOLOGIC ENDOVASCULAR EMBOLOTHERAPY METHODS
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WO/2000/071196	November, 2000			INTERFACE NEEDLE AND METHOD FOR CREATING A BLUNT INTERFACE BETWEEN DELIVERED LIQUIDS
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WO/2001/012359	February, 2001			NITINOL BALL BEARING ELEMENT AND PROCESS FOR MAKING
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Le H. T.

Fish & Richardson P.C.

What is claimed is:

1. A polymeric particle comprising a polyvinyl alcohol and having a diameter of about 500 microns or less, wherein the particle has a first density of pores in an interior region and a second density of pores at a surface region, the first density being different from the second density, and wherein the particle has a first average pore size in the interior region and a second average pore size at the surface region, the first average pore size being greater than the second average pore size.

2. The polymeric particle of claim 1, wherein the second density is greater than the first density.

3. The polymeric particle of claim 1, wherein the particle has a diameter of about 10 microns or more.

4. The polymeric particle of claim 1, wherein the particle has a diameter of about 100 microns or more.

5. The polymeric particle of claim 4, wherein the particle has a diameter of about 300 microns or less.

6. The polymeric particle of claim 1, wherein the particle has a diameter of about 300 microns or more.

7. The polymeric particle of claim 1, wherein the particle is at least partially coated with a substantially bioabsorbable material.

8. The polymeric particle of claim 1, wherein the particle has a density of from about 1.1 grams per cubic centimeter to about 1.4 grams per cubic centimeter.

9. The polymeric particle of claim 1, wherein the particle has a sphericity of about 0.9 or more.

10. The polymeric particle of claim 1, wherein, after compression to about 50 percent, the particle has a sphericity of about 0.9 or more.

11.