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7615593 |
Bifunctional-modified hydrogels
Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked...
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7612112 |
Methods of treatment using a gastric retained gabapentin dosage
A method of treatment for epilepsy and other disease states is described, which comprises the delivery of gabapentin in a gastric retained dosage form.
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7612051 |
Powder composition, dispersion of this powder composition in oil and cosmetic material containing same
This invention relates to a powder composition comprising a silicone represented by the following formula (1) comprising an alcoholic hydroxyl group, and a powder, to an oil-based powder...
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7592021 |
Bioadhesive delivery system for transmucosal delivery of beneficial agents
Formulations and methods for transmucosal delivery of a beneficial agent are described in which a pH-responsive component and a temperature-responsive component are combined and applied to a mucous...
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7589184 |
Stable protein storage and stable nucleic acid storage in recoverable form
The invention provides compositions and methods for storage of biomolecules. The biomolecules are stored via absorption to a substrate. Absorbed biomolecules can be eluted or recovered from the...
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7588761 |
Human antibodies that bind human TNFα
Human antibodies, preferably recombinant human antibodies, that specifically bind to human tumor necrosis factor α (hTNFα) are disclosed. These antibodies have high affinity for hTNFα (e.g., K d...
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7579014 |
Mesoporous compositions for use in drug delivery
The present invention encompasses novel mesoporous compositions comprising vitamin E and alumina, and methods for their synthesis. The mesoporous compositions of the present invention have...
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7556827 |
Implantable active ingredient depot
The invention relates to an implantable active ingredient depot for therapeutically active substances. The fields of application are in medicine and the pharmaceutical industry. The implantable...
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7550443 |
Process and systems for biocompatible surfaces
The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity that are...
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7550154 |
Methods of treatment with drug loaded polymeric materials
Polymeric microparticles have been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and can have targeting ligands directly bound to...
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7547449 |
Method for treating a bone defect with an organic/inorganic composite
The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for...
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7544371 |
Drug delivery systems
Matrix controlled diffusion drug delivery systems based on one or more silicone-containing monomers of the general formula:
wherein x, y, m, m′, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 ,...
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7541167 |
Porous glass composite material
A porous glass composite material comprising at least one alkoxodisilane (precursor) having the general formula (or 1 ) 3 Si-spacer-Si(OR 2 ) 3 ,wherein R 1 and R 2 are the same or different and...
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7534451 |
Bone restorative carrier mediums
Biocompatible bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities.
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7531004 |
Pliable conformable bone restorative
A pliable bone restorative having an osteoconductive foam that at least partially surrounds a biocompatible mesh and the foam comprises a biocompatible, resorbable polymer and calcium phosphate.
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7524514 |
Biomimetic composition reinforced by a polyelectrolytic complex of hyaluronic acid and chitosan
The present invention relates to a three dimensional, malleable cell culture composition and method of forming the same comprising hyaluronic acid, chitosan and a polyelectrolytic complex of...
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7514249 |
Biomimetic organic/inorganic composites
The subject invention concerns a composite comprising an organic fluid-swellable, fibrous matrix, such as collagen, and a mineral phase, such as calcium carbonate or phosphate mineral phase, for...
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7514248 |
Process for making organic/inorganic composites
The subject invention concerns a composite comprising an organic fluid-swellable matrix, such as collagen, and mineral phase, such as calcium carbonate or phosphate mineral phase, for use as a...
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7507422 |
Urinary tract tissue graft compositions and methods for producing same
A method for repairing damaged or diseased urinary tract tissue includes providing a urinary tract tissue graft composition that includes a distal ileal segment of small intestinal submucosa. The...
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7498412 |
Process for preparing porous collagen matrix from connective tissue
The subject invention provides a process for preparing a porous collagen matrix from connective tissue, said process comprising: a porous structure forming step to treat said connective tissue with...
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7498044 |
Dosage form and method for producing the same
The invention relates to a process for producing a coated drug form or a drug form in the form of an active ingredient matrix, by processing a copolymer, an active pharmaceutical ingredient, a core...
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RE40640 |
Injectable microfoam containing a sclerosing agent
Injectable microfoam for scleroteraphy. The sclerotherapy of varices is based on the injection of liquid substances capable of suppressing them. The present invention relates to the preparation of...
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7488498 |
Antidiabetic preparation for oral administration
There is provided a single preparation which directly decreases both of the post prandial blood glucose level and the fasting blood glucose level close to normal levels, by release-sustaining a...
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7488431 |
Lipiodol-ferrofluid, and a process for preparation thereof
The present invention discloses a lipiodol-ferrofluid, and a process for preparation thereof, wherein the lipiodol-ferrofluid includes the ferrofluid including a magnetic component, γ-Fe 2 O 3 or...
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7485617 |
Osteoinductive materials
The present invention concerns improved osteoinductive materials comprising matrix materials and morphogenetic roteins, wherein depending on the subject matter the proteins may be dimeric or...
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7485317 |
Thermo-reversible polymer for intralumenal implant
An intralumenal implant material, which comprises, a polymer having a sol-gel transition temperature in an aqueous solution thereof, shows a substantial water-insolubility at a temperature higher...
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7482023 |
Hygiene tissue with lactic acid producing bacterial strains
A hygiene tissue is used for both cleaning and transferring lactic acid producing bacteria to the skin and urogenital area. The hygiene tissue contains, on separate parts of the tissue, cleaning...
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7482019 |
Methods of producing modified microcrystalline chitosan and uses therefor
Disclosed are methods of producing modified microcrystalline chitosan. Chitosan in aqueous solution is degraded enzymatically, hydrolytically or oxidatively. The chitosan solution is then alkalized...
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7476689 |
Therapeutic compositions for intranasal administration which include KETOROLAC
An analgesic/anti-inflammatory pharmaceutical dosage form which comprises an effective amount of an active ingredient selected from the group consisting of racemic...
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7459172 |
Method of making a protein polymer and uses of the polymer
A polymer is prepared by self-assembly of a plurality of monomeric polypeptide units. The polymer tends to form a nanotube and is capable of encapsulating a particular drug molecule. Once...
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7439269 |
Composition and method for moisturizing nasal tissue
An improved composition and method for moisturizing a nasal membrane are disclosed. The composition includes a viscous carrier and one or more moisturizing agents disposed with the carrier. The...
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7438930 |
Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations
The invention is directed to oral modified/controlled release drug formulations which provide a rapid initial onset of effect and a prolonged duration of effect. Preferably, the peak concentration...
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7435427 |
Pharmaceutical semi-solid composition of isotretinoin
An oral pharmaceutical composition of isotretinoin containing at least two lipidic excipients, one of them being hydrophilic (i.e. having an HLB value superior or equal to 10), the other being an...
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7431943 |
Controlled release and taste masking oral pharmaceutical compositions
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic,...
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7429393 |
Process for forming centipede polymer gels
A process that enables the formation of a high damping, soft polymer gel includes reacting a maleimide copolymer with a maleated polyalkylene and an alkyl diamine under substantially dry conditions...
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7427602 |
Sustained DNA delivery from structural matrices
Disclosed are particular 3-dimensional structural matrices containing nucleic acids, various fabrication processes and methods for the prolonged release of nucleic acids in various biological...
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RE40493 |
Porous paclitaxel matrices and methods of manufacture thereof
Paclitaxel is provided in a porous matrix form, which allows the drug to be formulated without Cremophor and administered as a bolus. The paclitaxel matrices preferably are made using a process...
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7417021 |
Biologically active conjugate of a biopolymer and therapeutic agent
A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a...
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7416739 |
Composition and process for retaining active ingredients
A composition for retaining active ingredients in personal care compositions is described based on one or more polymers having a network structure in an oil phase in amounts from 0.01 to 10% by...
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7413753 |
Calcium phosphate delivery vehicles for osteoinductive proteins
A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an...
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7413747 |
Transdermal therapeutic system for treating Parkinsonism
A transdermal therapeutic system (TTS) comprises a silicone-based polymer adhesive system having distributed therein (−)-5,6,7,8-tetrahydro-6-[propyl-[2-(2-thienyl)ethyl]amino
]-1-naphthalenol...
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7407672 |
Composition derived from biological materials and method of use and preparation
The invention provides a novel composition and methods of its preparation and uses. The composition comprises as main components serum and a gelling agent and is useful in various medical...
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7407668 |
Medical articles having enzymatic surfaces for localized therapy
An enzymatically active medical article is provided, which comprises a medical article and an enzyme disposed at or near a surface of the medical article such that the medical article is provided...
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7402319 |
Cell-free tissue replacement for tissue engineering
The present invention is a natural, cell-free tissue replacement that does not require difficult or extensive preparation made by washing tissue replacement in a solution including one or more...
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7399483 |
Carrier with solid fibrinogen and solid thrombin
The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical...
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7399466 |
Method and compositions for promoting osteogenesis
The object of the present invention is to increase PHEX activity to improve the osteogenic process in a mammal where this process has been diminished due to pathology or a condition that require...
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7393437 |
Photochemically crosslinked collagen scaffolds and methods for their preparation
A method for producing collagen-based scaffolds with improved characteristics, which broadens the usage of collagen in tissue engineering and the products so produced are described. The method...
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7390506 |
Lipophilic drug compositions
The invention is directed to biologically active lipophilic compositions comprising a biologically active covalently attached to, or encapsulated within, a lipid. Preferably, a biologically active...
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7384653 |
Oral dosage form comprising a therapeutic agent and an adverse-effect agent
The present invention provides an oral dosage form comprising a first composition and a second composition. The first composition comprises an effective amount of a therapeutic agent and the second...
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7381715 |
Antimicrobial solid surface materials containing chitosan-metal complexes
A solid surface material with an antimicrobial agent in a thermoset and/or thermoplastic resin matrix where the antimicrobial agent comprises a chitosan-metal complex.
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