|
Match
|
Document |
Document Title |
|
|
7488719 |
Wound and cutaneous injury healing with a nucleic acid encoding perlecan
A description of a biomolecule named Perlecan which is added internally or topically, or is expressed from exogenously added nucleic acids, as a whole or in part, to a healing wound to improve the...
|
|
|
7485318 |
Biodegradable carrier and method for preparation thereof
A biodegradable carrier is produced for preservation and/or controlled delivery of biologically active agents where the biodegradable carrier is a silica xerogel which is made from water and silane...
|
|
|
7485291 |
Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof
Single vector constructs for expression of a functional antibody molecule are described. The vectors have a self-processing cleavage site between two heterologous DNA coding sequences allowing for...
|
|
|
7479386 |
HXHV virus, nucleic material, peptide material and uses
Isolated HXHV virus having the following characteristics:
(i) a DNA genome which is at least partially single-stranded, (ii) the said genome comprises one reading frame (ORF) encoding one...
|
|
|
7476530 |
Mycobacterium avium subspecies paratuberculosis oral vaccine and methods
A method of using selective binding properties of killed and live isolates of Mycobacterium avium subspecies paratuberculosis (Map) to gastrointestinal tract mucosa is described which permits:
...
|
|
|
7476382 |
Reovirus for the treatment of neoplasia
Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, are disclosed. The reovirus is administered so that it ultimately directly contacts cells of the neoplasm....
|
|
|
7473418 |
Pan cancer oncolytic vectors and methods of use thereof
Replication-competent adenoviral vectors which selectively replicate in cancer cells are provided. The replication-competent viral vectors comprise an E2F responsive promoter and/or a telomerase...
|
|
|
7470426 |
Treatment of neoplasms with viruses
The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic...
|
|
|
7468182 |
Lactobacillus acidophilus nucleic acids and uses thereof
Lactobacillus acidophilus NCFM nucleic acid molecules, polypeptides, fragments and variants thereof are provided in the current invention. In addition, fusion proteins, antigenic peptides, and...
|
|
|
7468181 |
Means and methods for the production of adenovirus vectors
The invention relates to methods and means for the production of adenoviral vectors on complementing cell lines, wherein the early region 4 open reading frame 6 (E4-orf6) encoding nucleic acid is...
|
|
|
7465583 |
Duplexed parvovirus vectors
The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are...
|
|
|
7465454 |
Yeast-based vaccines as immunotherapy
Compositions and methods for treating and/or preventing a variety of diseases and conditions that are amenable to immunotherapy and, in one particular embodiment, compositions and methods for...
|
|
|
7465443 |
Acellular antibordetella vaccine
The invention relates to an immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (AC-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of ...
|
|
|
7465442 |
Reduction of dermal scarring
Methods and compositions for reducing or inhibiting dermal scarring by expressing p21 WAF1/Cip1 in a wound site are provided.
|
|
|
7462351 |
Nucleic acid delivery
The present invention provides formulations and methods to enhance the delivery of nucleic acids to cells. Formulations comprising dextrin polymers in combination with sugars provide enhanced...
|
|
|
7459602 |
Mammalian cancer cell and transgenic mammal carrying human protooncogene and kit for diagnosing cancer using said protooncogene
The present invention provides a mammalian cell transfected with an expression vector comprising a human protooncogene which has the nucleotide sequence of SEQ ID NO: 1; a mammalian embryo carrying...
|
|
|
7459161 |
Methods for eliciting an immune response using cytolysin and hemolysin fusion proteins
The disclosure below provides a protein export system for efficiently producing recombinant protein from a host cell. In a preferred embodiment, the protein export system utilizes protein export...
|
|
|
7459154 |
Methods and reagents for the enhancement of virus transduction in the bladder epithelium
Agents and methods for enhancing recombinant virus transduction in the bladder epithelium are described. A first method involves contacting the luminal surface of the bladder with a composition...
|
|
|
7459153 |
Viral vectors for gene therapy
Adenovirus types 11p and 4p show a higher binding affinity and infectivity than type 5 for endothelial and carcinoma cell lines. Adenovirus type 11p shows a stronger binding to cells for neural...
|
|
|
7456009 |
Adenovirus formulations
The invention relates to viral formulations and related pharmaceutical products for use in gene therapy and/or vaccine applications. Especially preferred viral formulations disclosed herein are...
|
|
|
7456008 |
Modified virus comprising one or more non-native polypeptides
A modified virus including one or more non-native polypeptides, and the use of such viruses in therapy, particularly in the treatment of tumours or other cancerous cells are disclosed. The...
|
|
|
7452531 |
Compositions and methods for tumor-targeted delivery of effector molecules
The present application discloses the preparation and use of attenuated tumor-targeted bacteria vectors for the delivery of one or more primary effector molecule(s) to the site of a solid tumor....
|
|
|
7452530 |
Reversal of viral-induced systemic shock and respiratory distress by blockade of the lymphotoxin beta pathway
This invention provides methods of inducing an antiviral response in an individual comprising administering to the individual an effective amount of a LT-B blocking agent and a pharmaceutically...
|
|
|
7452529 |
Treatment of muscular dystrophy with cord blood cells
The invention features methods for treating a patient suffering from muscular dystrophy by administration of umbilical cord blood cells, e.g., by IV infusion.
|
|
|
7449178 |
Attenuated gram negative bacteria
Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is...
|
|
|
7446099 |
Compositions and methods for biodegradable polymer-peptide mediated transfection
Complexes are disclosed which are a combination of a polynucleotide and a biodegradable polyacetal-peptide. The disclosed complexes are useful for cell transfection.
|
|
|
7445929 |
Recombinant adenovirus vector having a reduced side effect
The present invention provides a novel adenovirus vector for which inflammation during the in vivo administration thereof is alleviated by inhibiting the induction of expression of an adenovirus...
|
|
|
7442540 |
Polynucleotide encoding coleopteran-toxic polypeptide
Disclosed are novel insecticidal polypeptides, and compositions comprising these polypeptides, peptide fragments thereof, and antibodies specific therefor. Also disclosed are vectors, transformed...
|
|
|
7438918 |
Lipid A deficient mutants of Neisseria meningitidis
The invention provides lipid A deficient mutant Neisseria meningitidis cells, pharmaceutical compositions incorporating such cells, and methods of using such cells.
|
|
|
7435723 |
Process for delivery of polynucleotides to the prostate
Disclosed is a system for providing in vivo delivery of polynucleotides to mammalian prostate cells using an intravascular administration route. The polynucleotides are inserted in an injection...
|
|
|
7435596 |
Modified cell line and method for expansion of NK cell
The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand...
|
|
|
7431922 |
Bioadhesive directed somatic cell therapy
The subject invention is related to a cell-mediated gene therapy treatment using a cell composition that includes bioadhesive material. The bioadhesive material allows targeted and localized...
|
|
|
7427396 |
AAV vectors for gene delivery to the lung
Methods of making and using recombinant AAV vectors and virions for gene delivery to the lung are described. The recombinant AAV virions are derived from caprine AAV and bovine AAV, both of which...
|
|
|
7427395 |
Chemotherapeutic agent-incorporated pharmaceutical preparation
An apparatus and a method of remote control which can enable real time operation of a device in home from a terminal device at remote location through a network are provided. A first server...
|
|
|
7425443 |
Treatment of diabetes with synthetic beta cells
Disclosed is a method for obtaining glucose-regulated expression of active insulin in the cells of a mammalian subject. The method involves delivering into the subject a genetic construct...
|
|
|
7419829 |
Vector system
The present invention provides a vector system comprising a mutated post-transcriptional regulatory element. In particular, the present invention relates to a mutated WPRE sequence that can...
|
|
|
7419827 |
Cell lines
Genomic instability in T-antigen expressing cells can be overcome by modifying the gene expressing T-antigen so that it lacks Bub1 binding. Stable cell lines can be produced by incorporation of the...
|
|
|
7419659 |
Expression control using variable intergenic sequences
The present invention relates to a method of production of antibodies wherein the heavy and light chains of a particular antibody molecule are encoded by the DNA present in a dicistronic message in...
|
|
|
7414173 |
Isolated nucleic acid molecules encoding orally active androctonus amoreuxi pesticidal biopeptides
The present invention provides compositions and methods for isolated nucleic acid molecules encoding orally active Androctonus amoreuxi pesticidal polypeptides. Compositions include novel...
|
|
|
7414020 |
Human checkpoint kinase, hCDS1, compositions and methods
The invention provides for a novel human checkpoint kinase gene, hCDS1, comprising the nucleic acid sequence of residues 66-1694 of SEQ ID NO: 1, a protein expressed from the gene, fragments and...
|
|
|
7413733 |
Antigen transduced T cells used as a delivery system for antigens
A delivery system comprising a T cell comprising at least one antigen capable of loading antigen-presenting-cells with the antigen.
|
|
|
7410954 |
Adenovirus serotype 30 (Ad30)
The present invention provides an adenovirus serotype 30 (Ad30) fiber amino acid sequence. The present invention also provides polynucleotides and expression vectors encoding an Ad30 fiber and...
|
|
|
7410644 |
Recombinant pox virus for immunization against tumor-associated antigens
Recombinant pox viruses capable of expressing cell-encoded, tumor-associated antigens are disclosed. The recombinant viruses are useful for evoking an immune response against the antigen.
|
|
|
7410637 |
Transgenic algae for delivering antigens to an animal
Delivery systems and methods are provided for delivering a biologically active protein to a host animal. The systems and methods provided include obtaining an algal cell transformed by an...
|
|
|
7408096 |
Expression of Cry3B insecticidal protein in plants
The present invention discloses methods and compositions comprising a novel expression cassette providing significantly improved levels of accumulation of Coleopteran inhibitory Cry3B variant...
|
|
|
7407801 |
Truncated CMV promoters and vectors containing same
The present invention relates to nucleic acid molecules comprising certain truncated forms of the human cytomegalovirus (CMV) immediate-early enhancer-promoter, either alone or operably linked to...
|
|
|
7407672 |
Composition derived from biological materials and method of use and preparation
The invention provides a novel composition and methods of its preparation and uses. The composition comprises as main components serum and a gelling agent and is useful in various medical...
|
|
|
7407661 |
Methods and reagents that generate a CD8 T cell immune response
New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes...
|
|
|
7404950 |
Induced activation in dendritic cell
The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions...
|
|
|
7402429 |
Host cells comprising cDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses, further encoding antigenically active proteins
The present invention relates, in general, to a methodology for the generation or nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued...
|