Matches 1 - 50 out of 92 1 2 >
Match Document Document Title
7550148 Targeting of Herpes simplex virus to specific receptors  
The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing...
7550138 Plasmodium mutant and vaccines including the mutant  
The invention relates to the production of new Plasmodium mutants which are defective in the expression of the protein P36p. These mutants are unable to cause malaria, yet they can be used as...
7544669 Polynucleotide therapy  
This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a...
7541447 Process for the preparation of an improved Brucella strain plasmid to develop the strain and the vaccine comprising the said strain  
A Brucella bacterium is modified by partial or complete deletion of the pgm gene, rendering the bacterium incapable of synthesizing a key enzyme in the metabolism of bacterial sugars. A live...
7541179 Vector encoding human globin gene and use thereof in treatment of hemoglobinopathies  
Recombinant lentiviral vectors having a region encoding a functional β-globin gene; and large portions of the β-globin locus control regions which include DNase I hypersensitive sites HS2, HS3...
7541043 Vaccine for protection against Shigella sonnei disease  
Compositions and methods for protecting a susceptable host against an infection of Shigella sonnei are disclosed. Such compositions and methods are useful for protecting the host against...
7534613 Methods of treating parkinson's disease using viral vectors  
Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
7534425 Animal model and cell-line expressing modified chlorine channel  
The present invention relates to a test system for the identification and testing of active compounds which act on synapic transmission (active compounds for treatment of neuronal diseases), which...
7531180 Chimeric alphavirus replicon particles  
Chimeric alphaviruses and alphavirus replicon particles are provided including methods of making and using same. Specifically, alphavirus particles are provided having nucleic acid molecules...
7531167 Herpes simplex virus vector  
The invention provides a herpes simplex virus vector comprising deletions in ICP4, ICP27, and UL55.
7524507 Recombinant microorganisms  
A method of enhancing expression of a desired protein at mucosal effector sites, the method including placing the protein to be expressed under the control of a promoter having SEQ ID NO: 2, SEQ ID...
7524493 Nucleic acid constructs cells transformed therewith and methods utilizing same for inducing liver regeneration and alleviation of portal hypertension  
A method of inducing liver regeneration in a damaged liver tissue region of an individual is provided. The method including the step of providing at least two distinct growth factors to the damaged...
7521229 Recombinant viral-based malaria vaccines  
The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alpha viruses, adenoviruses or vaccinia viruses. The recombinant viral-based...
7521043 Gene therapy for tumors using minus-strand RNA viral vectors encoding immunostimulatory cytokines  
The present invention provides methods for treating tumors, which comprise the step of administering into tumor sites a minus-strand RNA viral vector encoding an immunostimulatory cytokine or cells...
7517866 LIM mineralization protein splice variants  
The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising splice variants of nucleotide...
7517669 Gene regulation therapy involving ferritin  
A method is described for regulating gene expression related to iron metabolism to ameliorate diseases that include sickle cell disease, cancers, neurodegenerative diseases, Friedreich's ataxia and...
7517520 Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use  
The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G...
7510706 Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activity  
The present invention provides a retroviral vector containing a membrane protein having a hemagglutinin activity. The present inventors constructed a retroviral vector pseudotyped by the membrane...
7507722 Intravascular delivery of nucleic acid  
Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then...
7504100 Method for delivering a biological compound using neural progenitor cells derived from whole bone marrow  
A method is described for generating a clinically significant volume of neural progenitor cells from whole bone marrow. A mass of bone marrow cells may be grown in a culture supplemented with...
7501126 Targeting of herpes simplex virus to specific receptors  
The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific receptors. Also, recombinant vectors for producing such HSV particles. By reducing...
7498314 Expression vectors and uses thereof  
The present invention relates to novel vectors, to DNA vaccines and gene therapeutics containing said vectors, to methods for the preparation of the vectors and DNA vaccines and gene therapeutics,...
7498024 Compositions and methods for enhanced expression of immunoglobulins from a single vector using a peptide cleavage site  
Single vector constructs for expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The vectors comprise a self-processing cleavage...
7491525 Specific proliferation in tumour cell which can express antioncogene with high efficiency and the use of it  
The present invention provides a recombinant virus, which highly expresses a cancer therapeutic gene and specifically proliferates in tumor cells, and a method for the proliferation of the same. In...
7491508 Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses  
A method for providing an adenovirus from a serotype which does not grow efficiently in a desired cell line with the ability to grow in that cell line is described. The method involves replacing...
7491385 Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues  
Polynucleotide expression constructs, populations of cells and methods of treating diseases caused by dysfunction in, or damage to, excitable tissues are provided.
7488719 Wound and cutaneous injury healing with a nucleic acid encoding perlecan  
A description of a biomolecule named Perlecan which is added internally or topically, or is expressed from exogenously added nucleic acids, as a whole or in part, to a healing wound to improve the...
7485318 Biodegradable carrier and method for preparation thereof  
A biodegradable carrier is produced for preservation and/or controlled delivery of biologically active agents where the biodegradable carrier is a silica xerogel which is made from water and silane...
7485291 Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof  
Single vector constructs for expression of a functional antibody molecule are described. The vectors have a self-processing cleavage site between two heterologous DNA coding sequences allowing for...
7479386 HXHV virus, nucleic material, peptide material and uses  
Isolated HXHV virus having the following characteristics: (i) a DNA genome which is at least partially single-stranded, (ii) the said genome comprises one reading frame (ORF) encoding one...
7476530 Mycobacterium avium subspecies paratuberculosis oral vaccine and methods  
A method of using selective binding properties of killed and live isolates of Mycobacterium avium subspecies paratuberculosis (Map) to gastrointestinal tract mucosa is described which permits: ...
7476382 Reovirus for the treatment of neoplasia  
Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, are disclosed. The reovirus is administered so that it ultimately directly contacts cells of the neoplasm....
7473556 Method for producing dendritic cells  
Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one...
7473428 Recombinant porcine adenovirus vector  
This invention relates to a recombinant vector including a recombinant porcine adenovirus, stably incorporating and capable of expression of at least one heterologous nucleotide sequence. The...
7473419 Intravascular delivery of nucleic acid  
Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the...
7473418 Pan cancer oncolytic vectors and methods of use thereof  
Replication-competent adenoviral vectors which selectively replicate in cancer cells are provided. The replication-competent viral vectors comprise an E2F responsive promoter and/or a telomerase...
7470426 Treatment of neoplasms with viruses  
The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic...
7468182 Lactobacillus acidophilus nucleic acids and uses thereof  
Lactobacillus acidophilus NCFM nucleic acid molecules, polypeptides, fragments and variants thereof are provided in the current invention. In addition, fusion proteins, antigenic peptides, and...
7468181 Means and methods for the production of adenovirus vectors  
The invention relates to methods and means for the production of adenoviral vectors on complementing cell lines, wherein the early region 4 open reading frame 6 (E4-orf6) encoding nucleic acid is...
7465583 Duplexed parvovirus vectors  
The present invention provides duplexed parvovirus vector genomes that are capable under appropriate conditions of forming a double-stranded molecule by intrastrand base-pairing. Also provided are...
7465454 Yeast-based vaccines as immunotherapy  
Compositions and methods for treating and/or preventing a variety of diseases and conditions that are amenable to immunotherapy and, in one particular embodiment, compositions and methods for...
7465443 Acellular antibordetella vaccine  
The invention relates to an immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (AC-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of ...
7465442 Reduction of dermal scarring  
Methods and compositions for reducing or inhibiting dermal scarring by expressing p21 WAF1/Cip1 in a wound site are provided.
7462351 Nucleic acid delivery  
The present invention provides formulations and methods to enhance the delivery of nucleic acids to cells. Formulations comprising dextrin polymers in combination with sugars provide enhanced...
7459602 Mammalian cancer cell and transgenic mammal carrying human protooncogene and kit for diagnosing cancer using said protooncogene  
The present invention provides a mammalian cell transfected with an expression vector comprising a human protooncogene which has the nucleotide sequence of SEQ ID NO: 1; a mammalian embryo carrying...
7459161 Methods for eliciting an immune response using cytolysin and hemolysin fusion proteins  
The disclosure below provides a protein export system for efficiently producing recombinant protein from a host cell. In a preferred embodiment, the protein export system utilizes protein export...
7459154 Methods and reagents for the enhancement of virus transduction in the bladder epithelium  
Agents and methods for enhancing recombinant virus transduction in the bladder epithelium are described. A first method involves contacting the luminal surface of the bladder with a composition...
7459153 Viral vectors for gene therapy  
Adenovirus types 11p and 4p show a higher binding affinity and infectivity than type 5 for endothelial and carcinoma cell lines. Adenovirus type 11p shows a stronger binding to cells for neural...
7456009 Adenovirus formulations  
The invention relates to viral formulations and related pharmaceutical products for use in gene therapy and/or vaccine applications. Especially preferred viral formulations disclosed herein are...
7456008 Modified virus comprising one or more non-native polypeptides  
A modified virus including one or more non-native polypeptides, and the use of such viruses in therapy, particularly in the treatment of tumours or other cancerous cells are disclosed. The...
Matches 1 - 50 out of 92 1 2 >