|
Match
|
Document |
Document Title |
|
|
7604934 |
Method of screening candidate compounds for susceptibility to biliary excretion by endogenous transport systems
A method of screening a candidate compound for susceptibility to biliary excretion. The method includes the steps of providing a culture of hepatocytes, the culture having at least one bile...
|
|
|
7604929 |
Cellular compositions and methods for their preparation
The present invention relates to novel cell (e.g., hepatocyte, etc.) compositions and methods for their preparation and use. In particular, the invention concerns methods of processing preparations...
|
|
|
7601494 |
Method of screening candidate compounds for susceptibility to biliary excretion
A method of screening a candidate compound for susceptibility to biliary excretion by a hepatocyte transport protein. The method includes the steps of providing a culture of hepatocytes comprising...
|
|
|
7575911 |
Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids
A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These...
|
|
|
7575859 |
Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids
A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These...
|
|
|
7560282 |
System for the internal qualitative and quantitative validation of marker indices
The present invention relates to the qualitative and quantitative validation of marker indices, especially for medical diagnosis and particularly for the determination of the growth fraction in a...
|
|
|
7560279 |
Method of proliferating human hepatocytes and method for obtaining human hepatocytes
Transplanting human hepatocytes into a liver of an immunodeficient hepatopathy mouse, and then feeding the mouse transplanted with the human hepatocytes under such a condition as being protected...
|
|
|
7524493 |
Nucleic acid constructs cells transformed therewith and methods utilizing same for inducing liver regeneration and alleviation of portal hypertension
A method of inducing liver regeneration in a damaged liver tissue region of an individual is provided. The method including the step of providing at least two distinct growth factors to the damaged...
|
|
|
7521234 |
Mammalian immortalized liver cell
The present invention provides a mammalian immortalized liver cell obtained by transferring a cell proliferation factor gene located between a pair of site-specific recombination sequences into a...
|
|
|
7521199 |
Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter
The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the...
|
|
|
7473555 |
Protocols for making hepatocytes from embryonic stem cells
This disclosure provides a newly developed strategy and particular options for differentiating pluripotent stem cells into cells of the hepatocyte lineage. Many of the protocols are based on a...
|
|
|
7456018 |
Human hepatoma lines, methods for obtaining same and uses thereof
Human hepatoma cell lines are provided that comprises a set of cells clonally derived from a cancerous human liver cell, in which each cell of the set expresses a receptor having an affinity for...
|
|
|
7456017 |
Processes for clonal growth of hepatic progenitor cells
A method of propagating mammalian endodermally derived progenitors such as hepatic progenitors, their progeny, or mixtures thereof is developed which includes culturing mammalian progenitors, their...
|
|
|
7455969 |
Highly permissive cell lines for hepatitis C virus RNA replication
This invention relates generally to cells and cell lines that are permissive for hepatitis C virus (HCV) replication, and methods and materials for making and using them. The subject cell line...
|
|
|
7429376 |
Methods of screening for compounds that improve engraftment
The invention provides for methods of screening for compounds that increase the expression of P-selectin, SDF-1, and/or CXCR4 on facilitatory cells (FCs). The invention also provides for methods of...
|
|
|
7390651 |
C3A serum-free clonal cell line and methods of use
A serum-free C3A clonal cell line and methods for generating the same are provided. The C3A cell line has a reduced doubling time in serum-free medium compared to a corresponding C3A cell line from...
|
|
|
7371576 |
CD56 positive human adult pancreatic endocrine progenitor cells
The invention relates to the discovery of a selective cell surface marker that permits the selection of a unique subset of pancreatic stems cells having a high propensity to differentiate into...
|
|
|
7371384 |
Compositions and methods of using angiopoietin-like 4 protein antibody
ANGPTL4 compositions and methods of using such compositions, and agonists or antagonists thereof, for the diagnosis and treatment of diseases or disorders are included, including methods to...
|
|
|
7351584 |
Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids
A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These...
|
|
|
7344723 |
Self-replicating RNA molecule from hepatitis C virus
A unique HCV RNA molecule is provided having an enhanced efficiency of establishing cell culture replication. Novel adaptive mutations have been identified within the HCV non-structural region that...
|
|
|
7332336 |
Methods for inducing differentiation of pluripotent cells
The present invention provides methods for inducing the differentiation of pluripotent cells. The present inventors succeeded in differentiating hepatocytes from ES cells without EB formation,...
|
|
|
7329741 |
Polynucleotides that hybridize to DP-75 and their use
The present invention is a novel nucleic acid sequence which hybridizes to SEQ ID NO:6 or fragments thereof under stringent conditions, or fragments thereof. The invention also includes diagnostic...
|
|
|
7282366 |
Hepatocytes for therapy and drug screening made from embryonic stem cells
It has been discovered that when pluripotent stem cells are cultured in the presence of a hepatocyte differentiation agent, a population of cells is derived that has a remarkably high proportion of...
|
|
|
7282352 |
Homogeneity and secretion of recombinant proteins in mammalian systems
The present invention relates to a method for improving homogeneity and/or secretion of a recombinant protein of interest expressed in mammalian cells by replacing the endogenous signal peptide...
|
|
|
7256042 |
Process for making hepatocytes from pluripotent stem cells
It has been discovered that when pluripotent stem cells are cultured in the presence of a hepatocyte differentiation agent, a population of cells is derived that has a remarkably high proportion of...
|
|
|
7253150 |
Gene delivery vehicle expressing the aptosis-inducing proteins VP2 and/or apoptin
The invention relates to gene delivery vehicles which comprise nucleic acid molecules encoding apoptosis-inducing proteins VP2 and/or apoptin (VP3) like activity. VP2 and VP3 are viral proteins of...
|
|
|
7235353 |
Predicting hepatotoxicity using cell based assays
Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the...
|
|
|
7201911 |
Cloned genomes of infectious hepatitis C viruses and uses thereof
The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the...
|
|
|
7186553 |
Human derived immortalized liver cell line
The present invention relates to a new immortalized hepatocyte culture of human (preferably human fetal) normal cell origin. The immortalized hepatocyte culture of human normal cell origin of the...
|
|
|
7160719 |
Bioartificial liver system
A bioartificial liver system is described that incorporates a cell reservoir and hepatocyte spheroids to both increase the number of and longevity of cells in the system. Additional methods are...
|
|
|
7157275 |
Peptides for enhanced cell attachment and growth
The present invention relates to cell adhesion promoting (“CAP”) peptide combinations that promote cell attachment or cell adhesion to culture surfaces that are otherwise cell adhesion...
|
|
|
7094559 |
Assay to identify estrogen receptor dependent ligands that regulate the hepatic lipase promoter
The present invention relates to an assay system and method for testing compounds for their ability to regulate the hepatic lipase (HL) promoter. In particular, the invention relates to the...
|
|
|
7041501 |
Methods of screening for toxicity of test compounds
The present invention relates to methods of screening drug candidates for toxic effects on human cells. The invention provides methods for determining idiosyncratic toxicity of test compounds.
|
|
|
7033744 |
Method for proliferating a liver cell, a liver cell obtained thereby, and use thereof
The present invention provides a method comprising a step of transferring a cell proliferation factor gene into a mammalian liver cell to obtain an immortalized liver cell, a step of proliferating...
|
|
|
7022520 |
Cell culture media for mammalian cells
A chemically defined mammalian cell culture medium is provided that supports maintenance and long term clonal growth of mammalian hepatocytes and other cells.
|
|
|
7015036 |
Human liver cell line
In this application is described the establishment and maintanence of a normal human hepatocyte cell line able to support complete development of malaria parasite development in vitro. Advantages...
|
|
|
7011976 |
Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof
Replication competent adenoviral vectors specific for cells expressing alfa-fetoprotein (AFP) are provided. These replication-competetent adenoviral vectors comprise adenovirus genes essential for...
|
|
|
7008634 |
Cell growth substrates with tethered cell growth effector molecules
Described are compositions with tethered growth effector molecules, and methods of using these compositions for growing cells and tissues. Growth effector molecules, including growth factors and...
|
|
|
6995299 |
Propagation of human hepatocytes in non-human animals
The present invention relates to the preparation of non-human animals having chimeric livers, whereby some or substantially all of the hepatocytes present are human hepatocytes. It is based, at...
|
|
|
6972194 |
Use of polyacrylamide gel for forming a connective-tissue capsule in a mammal for cultivating allogenic and xenogenic cells
The invention relates to the field of medicine and more particularly it relates to the problem of vaccination against tumor cells and vaccinotherapy of oncological diseases, and also to a method of...
|
|
|
6969583 |
Method for detecting variant HBV
The present invention relates generally to an assay for detecting variant Hepatitis B viruses (HBVs) which exhibit altered sensitivity to agents. The variant HBVs are delivered to cells using a...
|
|
|
6924128 |
Packaging cell lines for generation of high titers of recombinant AAV vectors
AAV vectors may have utility for gene therapy but heretofore a significant obstacle has been the inability to generate sufficient quantities of such recombinant vectors in amounts that would be...
|
|
|
6897045 |
Adeno-associated virus vectors
The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated...
|
|
|
6858146 |
Artificial liver apparatus and method
Artificial liver devices and methods for using the devices to purify a biological fluid are disclosed. The methods include the use of living hepatocytes ( 23 ) which are either unattached or...
|
|
|
6815203 |
Methods of making pancreatic islet cells
The invention features methods of promoting dedifferentiation of pancreatic cells, methods of obtaining pancreatic islet cells from the dedifferentiated pancreatic cells, and methods of treating a...
|
|
|
6780580 |
Method of screening candidate compounds for susceptibility to biliary excretion
A method of screening a candidate compound for susceptibility to biliary excretion. The method includes the steps of providing a culture of hepatocytes, the culture having at least one bile...
|
|
|
6756229 |
Human cell line showing stable expression of cytochromes P450
This invention relates to cell lines that are obtained using cultured cell lines derived from human liver as a host and that stably express a number of human cytochromes P450. The human...
|
|
|
6689559 |
Efficient hepatitis C virus replicon and its use in identifying antiviral compounds
The present invention provides a Hepatitis C Virus (HCV) replicon that efficiently replicates in an eukaryotic cell. The HCV replicon includes a nucleic acid sequence encoding a subgenomic...
|
|
|
6653105 |
Clonal cells and cell lines derived from C3A cells and methods of making and using them
A serum-free C3A clonal cell line and methods for generating the same are provided. The C3A cell line has a reduced doubling time in serum-free medium compared to a corresponding C3A cell line from...
|
|
|
6635431 |
LSR receptor, activity, cloning, and uses for diagnosing, preventing and/or treating obesity and related risks or complications
The present invention relates to a new complex receptor polypeptide LSR (Lipolysis Stimulated Receptor), characterized by its functional activities, the cloning of the cDNAs complementary to the...
|