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7605170 |
8-azabicyclo[3.2.1]octane derivatives
The present invention relates to a 8-azabicyclo[3.2.1] octane derivative of Formula I,
wherein each of the substituents is given the definition as set forth in the specification and claims, or...
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7592355 |
Quinolinone-carboxamide compounds as 5-HT, receptor agonists
The invention provides novel quinolinone-carboxamide 5-HT 4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such...
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7589207 |
Cyclohexyl compounds as CCR5 antagonists
The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in...
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7589104 |
Tricyclic-bridged piperidinyline derivatives as §-opioid modulators
Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows:
wherein A, G, Y, R 3 , R...
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7589103 |
Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators
Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows:
wherein A, Z, Y, R 1 -R 5...
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7585877 |
Aminophenyl derivatives as selective androgen receptor modulators
Disclosed herein is a novel class of aminophenyl compounds having the structure:
wherein R 1 is cyano or nitro and ring A is a bi- or tricyclic bridged heterocycle and to their use as...
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7579361 |
Muscarinic acetylcholine receptor antagonists
Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
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7576097 |
Tropane derivatives useful in therapy
The present invention provides compounds of the formula:
wherein R 1 is C 3-6 cycloalkyl optionally substituted by one or more fluorine atoms, or C 1-6 alkyl optionally substituted by one or...
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7576096 |
Muscarinic acetylcholine receptor antagonists
Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
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7569582 |
Aminotropane derivatives, preparation thereof and therapeutic use thereof
The present invention relates to compounds of formula (I) as defined herein that are melanocortin receptor agonists, to the preparation thereof and to the therapeutic use thereof in the treatment...
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7569581 |
Anticholinergics which may be used as medicaments as well as processes for preparing them
The present invention relates to new anticholinergics of general formula 1
wherein A, X − , and the groups R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 may have the meanings given in the...
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7569579 |
Cyclopropyl compounds as ccr5 antagonists
The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in...
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7563803 |
M3 muscarinic acetylcholine receptor antagonists
Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
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7553850 |
Tricyclic-bridged piperidinylidene derivatives as δ-opioid modulators
Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows:
wherein A, G, Y, R 3 , R...
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7541368 |
Pyrazoles as inhibitors of tumor necrosis factor
The present invention provides compounds of Formula (I)
and ester prodrugs, pharmaceutically acceptable salts or solvates of such compounds; or ester prodrugs of such salts or solvates;...
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7507747 |
Muscarinic acetylcholine receptor antagonists
Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
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7507745 |
Pharmaceutical compositions based on fluorenecarboxylic acid esters and soluble TNF receptor fusion proteins
The present invention relates to novel pharmaceutical compositions based on fluorene carboxylic acid ester derived anticholinergics of formula 1
and soluble TNF receptor fusion proteins,...
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7488737 |
Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nACh receptors), activation of nACh receptors, and the treatment of disease conditions...
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7485650 |
High affinity ligands for nociceptin receptor ORL-1
The compound of the formula
or a pharmaceutically acceptable salt or solvate thereof, pharmaceutical compositions therefore, and the use of said compounds as nociceptin receptor inhibitors...
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7479494 |
3-monosubstituted tropane derivatives as nociceptin receptor ligands
Compounds of the formula
or a pharmaceutically acceptable salt thereof, wherein
R 1 is aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl,...
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7459464 |
Triple monoamine reuptake inhibitors for the treatment of chronic pain
The present invention relates to the use of triple monoamine reuptake inhibitors for the treatment of chronic pain.
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7456192 |
3β-amino azabicyclooctane heteroaromatic amid derivatives preparation method and therapeutic uses thereof
The invention concerns compounds of general formula 1, wherein: A, B, D and E represent one or two nitrogen atoms, the others being carbon atoms; X represents a S or, a O, thereby forming a...
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7446114 |
Quinolinone compounds as 5-HT4 receptor agonists
The invention provides novel quinolinone-carboxamide 5-HT 4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such...
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7439255 |
Muscarinic acetylcholine receptor antagonists
Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.
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7429601 |
Esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
The present invention relates to new compounds of general formula 1
wherein X − and the groups A, B, R, R 1 , R 2 , R 3 , R 3′ , R 4 , R 4′ , R x and R x′ may have the meanings given...
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7429600 |
Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
Fluorenecarboxylic acid esters of general formula 1
wherein X − and the groups A, R, R 1 , R 2 , R 3 , R 3′ , R 4 , and R 4′ have the meanings given in the claims and in the...
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7419989 |
Indazole-carboxamide compounds
The invention provides novel indazole-carboxamide 5-HT 4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such...
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7417051 |
Medicaments comprising betamimetics and a novel anticholinergic
A pharmaceutical composition comprising:
(a) a salt of formula 1
wherein:
X − is an anion with a single negative charge; and (b) a betamimetic 2,
or a solvate or hydrate thereof,...
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7410961 |
2,6-disubstituted piperiddines as modulators
The present invention is further directed to compounds of formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 16 , R 17 , R 18 , R 19 , R 20 , R 21 and R 22 are as...
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7407970 |
8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
This invention relates to novel 8-aza-bicyclo[3.2.1]octane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these...
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7405224 |
Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
Xanthenecarboxylates of formula 1
wherein:
A is a group selected from
X − is an anion with a single negative charge; R is hydroxy, methyl, hydroxymethyl, ethyl, —CF 3 , —CHF 2 , or...
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7381733 |
Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases
The present invention relates to the use of tropane derivatives having dopamine reuptake inhibitor activity for the treatment of diseases associated with reduced blood flow to the brain or with...
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7381723 |
Azabicyclylmethyl derivatives of 7,8-dihydro-1,6,9,-trioxa-3-aza-cyclopenta[a]naphthalene as 5-HT1A antagonists
Compounds of the formula
are useful for treating the cognitive deficits due to aging, stroke, head trauma, Alzheimer's disease or other neurodegenerative diseases, or schizophrenia and are also...
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7375114 |
Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
The invention provides novel quinolinone-carboxamide 5-HT 4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such...
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7368460 |
Tropane derivatives useful in therapy
The present invention provides compounds of the formula:
wherein R 1 is C 3-6 cycloalkyl optionally substituted by one or more fluorine atoms, or C 1-6 alkyl optionally substituted by one or...
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7361667 |
4′,4″-substituted 3α-(diphenylmethoxy) tropane analogs for treatment of mental disorders
The present invention describes a method for the treatment of attention deficit hyperactivity disorder (ADHD), conduct disorder, alcohol addiction, tobacco addiction, nicotine addiction,...
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7358244 |
Azabicycloalkane compounds
This invention provides compounds of formula I:
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or...
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7351704 |
Indazole-carboxamide compounds as 5-HT4 receptor agonists
The invention provides novel indazole-carboxamide 5-HT 4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such...
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7345056 |
Bridged N-cyclic sulfonamido inhibitors of gamma secretase
The invention provides N-cyclic sulfonamido compounds and salts of Formula I:
wherein A is as described in the specification and R 1 and R 2 combine to form a [3.3.1] or a [3.2.1] ring...
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7317022 |
Benzoimidazolone-carboxamide compounds as 5-HT4 receptors agonists
The invention provides novel benzoimidazolone-carboxamide 5-HT 4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using...
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7314870 |
Compounds, their preparation and use
The present invention relates to novel compounds that are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due...
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7307087 |
Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance
This invention relates to use of the combined action of a nicotinic acetylcholine receptor agonist and a monoaminergic substance for the treatment of affective disorders, as well as to...
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7300928 |
Benzimidazolidinone derivatives as muscarinic agents
Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M 1 and/or M 4 receptor...
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7297693 |
Nitrogen-containing heterocyclic compounds and their use as Raf inhibitors
Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac...
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7294636 |
Chemical compounds
Compounds of formula (I): compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal)
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7276521 |
Muscarinic acetylcholine receptor antagonists
Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
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7276520 |
Bicyclic piperidine derivatives as melanocortin-4 receptor agonists
Certain novel bicyclic N-acylated piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R)....
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RE39820 |
Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
Compounds of the formula
of which, in exemplary compounds, the thienyl group is attached via the 2-position and;
(a) A is 3α-(6β, 7β-epoxy)-tropanyl methobromide and R 1 is...
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7244415 |
HFA suspension formulations of an anhydrate
The invention relates to propellant gas formulations containing suspensions of the crystalline anhydrate of...
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7241745 |
Pyridyl alkene and pyridyl alkine acid amides as cytostatics and immunosupressives
The invention relates to a new pyridyl alkene and pyridyl alkine acid amides according to the general formula (I)
as well as methods for their production, medicaments containing these compounds...
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