|
Match
|
Document |
Document Title |
|
|
7615571 |
Process for manufacture of pure (2S, 3aS, 7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl) butyl]amino]-1-oxopropyl] octahydro-1H-indole-2-carboxylic acid and its tert. butyl amine salt
New compounds useful as synthetic intermediates to synthesize perindopril, a new process for synthesizing perindopril, and new salts of perindopril.
|
|
|
7592359 |
Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
This invention generally relates to derivatives of substituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment...
|
|
|
7582770 |
Viral polymerase inhibitors
An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I:
wherein A, B, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 are as defined herein, or a...
|
|
|
7579370 |
Fused heterocycles
This invention provides fused heterocycles having the formula:
in which R 1 is a member selected from the group consisting of H, substituted or unsubstituted arylalkyl and substituted or...
|
|
|
7576120 |
Azabicyclic compounds, a process for their preparation and pharmaceutical compositions containing them
A compound selected from those of formula (I):
wherein
m and n, which may be identical or different, each represent an integer from 0 to 2 inclusive, with the sum of the two integers...
|
|
|
7572787 |
Substituted naphthalene sulfonamides
The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful...
|
|
|
7572783 |
Substituted benzofused heterocycles
The present invention relates to the compounds of Formula I, their preparation and pharmaceutical compositions comprising them. The compounds and pharmaceutical compositions are useful, for...
|
|
|
7572606 |
Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs
Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve,...
|
|
|
7566715 |
Substituted sulfonamide compounds useful for the prophylaxis and treatment of conditions relating to obesity, type II diabetes and/or disorders of the central nervous system
The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the...
|
|
|
7560479 |
3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
This invention relates to derivatives of 3,6-disubstituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists and can be used for the treatment of...
|
|
|
7544708 |
Azabicyclo derivatives as muscarinic receptor antagonists
This invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal...
|
|
|
7531567 |
Use of a medicament containing an effector of the glutathione metabolism together with α-lipoic acid in kidney replacement therapy
The invention relates to the use of the combination of n-lipoic acid and effectors of the glutathione metabolism for the treatment of disturbances of the cellular thiol status and accompanying...
|
|
|
7517905 |
Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
This invention relates to the derivatives of substituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists and can be used for the treatment of...
|
|
|
7495109 |
Nociceptin analogs
A compound of the formula (I), (II), (III) or (IV)
wherein
Z, A, B, C, R, R 1 , R 2 , Q, and n are as described herein.
|
|
|
7491831 |
PPAR active compounds
Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
|
|
|
7482472 |
Substituted isoindoles and their use
The invention relates to coagulation of the blood. Disclosed are novel compounds of formula (I),
a method for the production of these compounds, pharmaceutical compositions containing them, and...
|
|
|
7476689 |
Therapeutic compositions for intranasal administration which include KETOROLAC
An analgesic/anti-inflammatory pharmaceutical dosage form which comprises an effective amount of an active ingredient selected from the group consisting of racemic...
|
|
|
7465811 |
Indoline compounds
Sulfonylindoline compounds of formula I,
wherein R1 through R4, Y and Z have defined meanings, a process for preparation of such compounds, and the use as pharmaceutically active substances,...
|
|
|
7429610 |
Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents
Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of indole-3-carbinol metabolites wherein the structures and substituents of the...
|
|
|
7425574 |
Benzofuran oxyethylamines as antidepressants and anxiolytics
Novel benzofuranoxyethylamines of the formula (I), in which R 1 , R 2 , R 3 , R 4 , m and n have the meanings indicated in Patent Claim ( 1 ), which have a strong affinity to the 5 HT 1A receptors...
|
|
|
7425562 |
Inhibitors of cruzipain and other cysteine proteases
Compounds of general formula (I) or general formula (II)
wherein R 1 , P 1 , P 2 , Q, Y, (X) o , (W) n , (V) m , Z and U are as defined in the specification, are inhibitors of cruzipain and...
|
|
|
7419975 |
Organic compounds
Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
|
|
|
7410993 |
3,6-disubstituted azabicyclo [3.1.0] hexane deriviatives useful as muscarinic receptor antagonists
This invention generally relates to the derivatives of 3,6 disubstituted azabicyclo[3.1.0] hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful, inter-alia,...
|
|
|
7407989 |
Compounds useful for modulating abnormal cell proliferation
There is described compounds of Formula I, and salts, solvates and hydrates thereof:
wherein: R 1 , R 2 and R 3 are each independently selected from OH, C 1-6 alkyl, OC 1-6 alkyl, OC(O)C 1-6...
|
|
|
7407983 |
Indole derivatives substituted with long-chain alcohols and medicaments containing them
Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I):
wherein R 1 , R 2 , R 3 and R 4 each independently represent a hydrogen...
|
|
|
7399779 |
3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonists
This invention generally relates to the derivatives of novel 3,6 disubstituted azabicyclo[3.1.0]hexanes. The compounds of this invention are muscarinic receptor antagonists which are useful,...
|
|
|
7393867 |
Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase I
The present invention discloses and claims compounds of formula (I) and formula (II),
as inhibitors of human casein kinase Iε and methods for using said compounds for treating central nervous...
|
|
|
7388027 |
Bicyclic compounds as modulators of androgen receptor function and method
The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen...
|
|
|
7381738 |
Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
The present application describes modulators of MCP-1 of formula (I):
or stereoisomers or pharmaceutically acceptable salts thereof, wherein X, Z, a, b, c, d, n, R 1 , R 2 , R 3 , R 4 , R 5 , R...
|
|
|
7378440 |
Substituted benzoylureido-o-benzoylamides, process for their preparation and their use
The invention relates to substituted benzoylureido-o-benzoylamides and to their physiologically tolerated salts and physiologically functional derivatives. The invention relates to compounds of...
|
|
|
7375126 |
Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
The present invention discloses novel compounds of general formula (I)
or a pharmaceutically acceptable salt or prodrug thereof (in which X 1 -X 5 , R 5 -R 8b , Z 1 -Z 2 and Ar 1 are defined...
|
|
|
7368469 |
Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
Use of an inhibitor of the renin-angiotensin system or a pharmaceutically acceptable derivative thereof, optionally together with another antihypertensive, a cholesterol lowering agent, a diuretic...
|
|
|
7368468 |
Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them
Provided are polymorphic forms of fluvastatin sodium and processes for their preparation.
|
|
|
7354948 |
Methods for treatment of chronic uveitis using cyclopropyl-n-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide
Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass...
|
|
|
7348352 |
Diindolylmethane for the treatment of HPV infection
New methods and compositions are disclosed that comprise the phytochemical Diindolylmethane, alone or in combination with immune potentiating steroids. These methods and compositions are utilized...
|
|
|
7348351 |
Substituted 3-alkyl and 3-arylalkyl 1H-indol-1yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
The invention formula substituted 3-alkyl and 3-arylalkyl 1H indol-1yl acetic acid derivatives which are useful as inhibitors of plasminogen activator inhibitor (PAI-1) useful for treating...
|
|
|
7345081 |
Azabicyclo-octane inhibitors of IAP
The invention provides novel inhibitors of IAP that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I:
X 1 and X 2 are independently...
|
|
|
7342040 |
5-fluorooxindole-3-carboxylic acid ester
A 5-fluorooxindole-3-carboxylic acid ester represented by a formula (2):
wherein R 1 is a group selected from the group consisting of an unsubstituted or substituted alkyl group having 1...
|
|
|
7323488 |
Chromogenic enzyme substrates
This invention provides novel chromogenic enzyme substrates which are indoxyl β-D-ribofuranosides. A process for their production is provided. Methods for detecting β-D-ribofuranosidase activity...
|
|
|
7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
|
|
|
7319097 |
Compounds
The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the...
|
|
|
7312239 |
Medicament for prevention and/or therapy of arterial wall disorder
An object of the present invention is to provide a medicament and method which is useful for prevention and/or therapy of arterial wall injury. According to the present invention, there is provided...
|
|
|
7288562 |
Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives as muscarinic receptor antagonists
This invention generally relates to the derivatives of novel 3,6 disubstituted azabicyclo[3.1.0] hexane's. The compounds of this invention are MUSCARINIC receptor antagonists which are useful,...
|
|
|
7279494 |
Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues
The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of formula I
or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents,...
|
|
|
7271192 |
Substituted 2-pyrrolidine-2-yl-1H-indole compounds
Novel 2-pyrrolidin-2-yl-1H-indole compounds corresponding to formula (I)
wherein R 1 , R 2 , R 3 and R 4 have the meanings given in the description, and pharmaceutical compositions containing...
|
|
|
7265148 |
Substituted pyrrole-indoles
The present invention relates generally to substituted pyrrole-indoles such as substituted pyrrole-indoles, and methods of using them.
|
|
|
7259181 |
β crystalline form of perindopril tert-butylamine salt
A β crystalline form of the compound of formula (I):
characterized by its powder X-ray diffraction data.
Medicinal products containing the same which are useful as inhibitors of angiotensin I...
|
|
|
7241798 |
NK1 antagonists
The invention is to compounds exhibiting neurokinin inhibitory properties, pharmaceutical compositions comprising same and methods of treatment for neurokinin-mediated conditions.
|
|
|
7241797 |
Method of increasing milk production
The invention relates generally to the use of pharmaceutical compositions to increase milk production alone or in combination with certain biological active ingredients. Specifically, the method...
|
|
|
7230024 |
Cannabinoid receptor ligands and uses thereof
Compounds of Formula (I) and (II) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the mediation of the cannabinoid receptors in animals are described...
|