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7070992 Retroviral vectors with foreign-sequence insertion between retroviral primer binding site and retroviral splice donor  
The subject of the invention is retroviral gene transfer vectors in which foreign sequences are introduced between the retroviral primer binding site (PBS) and the retroviral splice donor (SD). The...
7070807 Branched histidine copolymers and methods for using same  
The invention provides a branched transport polymer characterized as having at least 10 amino acids and a ratio of histidine to non-histidine amino acids greater than 1.5, said branched transport...
7067497 Modulation of telomere length by oligonucleotides having a G-core sequence  
Modified oligonucleotides having a GGG motif sequence and a sufficient number of flanking nucleotides to modulate the telomere length of a chromosome are provided. Methods of modulating telomere...
7067496 Methods for introducing genes into mammalian subjects  
Methods to obtain genetic modifications of cells in histoculture are described. Modification is assisted by treating the histoculture with collagenase prior to contacting the histoculture with the...
7067495 Compositions and methods for tumour therapy  
Compositions and methods are described that decrease or inhibit osteonectin activity in tumor cells, including cancer cells. The cells cease to be tumor-like, or become less tumor-like....
7067256 Ribozyme mediated inactivation of the androgen receptor  
The present invention provides synthetic ribozyme oligonucleotides alone and within constructs. The ribozyme gene provides methods for the treatment of prostate hyperplasia and other androgen...
7067139 Method for treating autoimmune diseases  
A method of treating patients having rheumatoid arthritis by administering Product R, a peptide-nucleic acid preparation, is disclosed.
7067135 Methods and compositions for the treatment and prevention of Staphylococcus aureus infections  
The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, Staphylococcus spp., particularly S. aureus.
7064111 Use of soluble costimulatory factor for tumor immuno-gene therapy  
A new gene therapy entails tumor treatment by introducing an expressible nucleotide sequence for a soluble costimulatory factor, thereby enhancing the response of T-cells to a tumor. In vivo...
7060690 Methods and compositions for treating a cell-proliferative disorder using CRE decoy oligomers, BCL-2 antisense oligomers, and hybrid oligomers thereof  
The present invention is directed to hybrid oligomers comprising a cyclic AMP response element (CRE) sequence and a sequence that hybridizes to a bcl-2 pre-mRNA or mRNA, and pharmaceutical...
7060689 Methods and compositions for delivery and retention of active agents to lymph nodes  
The present invention is directed to delivery and retention of active agents to targeted lymph nodes in a mammal using a ligand/anti-ligand pair. More particularly, the invention involves methods,...
7060688 Products and methods for controlling the suppression of the neoplastic phenotype  
A method for gene therapy for cancers wherein chromosomal location of an inactive or defective cancer suppressing gene is established, a replacement gene which is preferably cloned is then used to...
7060687 Live vaccines for allergy treatment  
The invention relates to transformed bacteria of the genus Lactobacillus or Streptococcus, the bacteria having a DNA molecule that includes (1) a nucleotide sequence that encodes a protein...
7060500 Single-stranded oligodeoxynucleotide mutational vectors  
The invention concerns the introduction of predetermined genetic changes in target genes of a living cell by introducing an oligodeoxynucleotide encoding the predetermined change. The...
7060499 DNA containing variant FRT sequences  
To provide DNA comprising mutant FRT sequence which causes recombination reaction between two mutant FRT sequences having an identical sequence to each other but does not cause recombination...
7060498 Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers  
The present provides a carrier molecule for transporting a polyanioic macromolecule such as a nucleic acid across a biological barrier of a cell. The carrier has a biocompatible backbone polymer...
7056901 Microgel particles for the delivery of bioactive materials  
Novel microgels, microparticles and related polymeric materials capable of delivering bioactive materials to cells for use as vaccines or therapeutic agents. The materials are made using a...
7056897 Inducible expression vectors and methods of use thereof  
The present invention relates to inducible gene expression constructs and methods of inducing gene expression using a combination of inducing agents.
7056896 Carbohydrate or 2′-modified oligonucleotides having alternating internucleoside linkages  
Novel compounds that mimic and/or modulate the activity of wild-type nucleic acids. In general, the compounds are oligonucleotides which contain at least one region of 2′-modified nucleosides...
7056895 Tirazole nucleoside analogs and methods for using same  
Novel heterocyclic aromatic compounds are disclosed. The novel compounds or pharmaceutically acceptable esters or salts thereof may be used in pharmaceutical compositions, and such compositions may...
7056704 RNA interference mediating small RNA molecules  
Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we...
7056702 Detecting lipocalin  
The invention provides antibodies reactive with distinct lipocalin epitopes that are useful for detecting inflammation and bacterial infections in mammals.
7056332 Nucleic acid biomaterials and methods of formation and use  
Polymers that are biocompatible are useful for various medical purposes such as tissue repair, reconstruction and wound healing. A method and composition for producing a biocompatible polymer...
7053150 Segmented polymers and their conjugates  
Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene...
7053063 Controlled electroporation and mass transfer across cell membranes in tissue  
Electroporation is performed in a controlled manner in individual and multiple biological cells present in biological tissue by monitoring the electrical impedance, defined herein as the ratio of...
7053062 Compositions and methods for inducing gene expression  
The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of...
7053052 Therapies involving mutated heat shock transcription factor  
The present invention relates to exogenous mutant HSF (mutHSF encoded by exogenous DNA) alters expression or synthesis of endogenous heat shock protein (hsp) genes in eukaryotic cells, tissues and...
7052903 Compositions and methods for activating genes of interest  
Compositions and methods for activating genes of interest are provided. The compositions comprise a masked targeted expression cassette which expresses a gene product only in the presence of a...
7052899 Toxoplasma gondii proteins, nucleic acid molecules, and uses thereof  
The present invention relates to immunogenic Toxoplasma gondii proteins, to T. gondii nucleic acid molecules, including those that encode such proteins and to antibodies raised against such...
7052692 Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression  
The present invention identifies a protein, designated the D-sequence-binding protein (D-BP), is phosphorylated at tyrosine residues and blocks AAV-mediated transgene expression in infected cells...
7049302 Compositions of CPG and saponin adjuvants and uses thereof  
Vaccine compositions of immunostimulatory oligonucleotides and saponin adjuvants and antigens and the use thereof for stimulating immunity, enhancing cell-mediated immunity, and enhancing antibody...
7049142 Gene expression with covalently modified polynucleotides  
A process and compound wherein nucleic acids can be modified with a host of molecules and maintain their ability to be expressed. A modifying chemical attachment of polyions to polynucleotides can...
7049140 X-ray guided drug delivery  
A method of delivering an active agent to a target tissue, particularly neoplastic tissue, vascular anomaly or tumor tissue, in a vertebrate subject. The method includes the steps of exposing the...
7049134 Rolling circle replicon expression vector  
A rolling circle DNA replicon which replicates in a host eukaryotic cell is disclosed which has a truncated replication cycle. The rolling circle DNA replicon comprises the following elements...
7049132 Stress-responsive induction of a therapeutic agent and methods of use  
This invention relates to compositions and methods for selective expression of a heterologous nucleic acid sequence in a targeted tissue, and more particularly to the glucose regulated protein 78...
7049128 Platelet glycoprotein Ibα fusion polypeptides and methods of use thereof  
The present invention provides compositions and methods for treating or preventing vascular-associated disorders.
7049117 Mutant possessing uracil phosphoribosyl transferase activity  
The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence...
7049061 Stereochemical control of the DNA binding affinity, sequence specificity, and orientation-preference of chiral hairpin polyamides in the minor groove  
This invention provides improved polyamides comprising a hairpin loop derived from γ-aminobutyric acid which bind to the minor groove of a promoter regions of a DNA sequence. Binding of the...
7048931 Compositions and methods for the therapy and diagnosis of prostate cancer  
Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions...
7045509 Proteins and nucleic acids encoding same  
Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as...
7045508 Use of rapamycin to inhibit immune response and induce tolerance to gene therapy vector and encoded transgene products  
Disclosed are methods for transient co-administration of rapamycin together with a gene therapy vector encoding a transgene. The present invention is directed to inhibiting the immune response of a...
7045347 Helper dependent adenovirus vectors based on integrase family site-specific recombinases  
This invention provides helper-dependent adenovirus cloning vectors and helper adenoviruses, and methods for making and Using such preparations, wherein the helper adenoviruses contain recombinase...
7045344 Adenoviral vector and methods for making and using the same  
In vitro methods for making a recombinant adenoviral genome, as well as kits for practicing the same and the recombinant adenovirus vectors produced thereby, are provided. In the subject methods,...
7045315 Methods for modulating expression of exogenous genes in mammalian systems  
In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in an isolated cell and in a mammalian subject employing modified...
7045306 Method for identifying compounds in vitro that modulate the dysregulation of transcription of transcription mediated by mutant huntingtin protein  
The invention relates to methods and products for deregulating gene transcription in neurodegenerative disease associated with an expanded polyglutamine tract in mutant proteins. The invention is...
7045293 Alteration of sequence of a target molecule  
Method for splicing a target nucleic acid molecule with a separate nucleic acid molecule. Such splicing generally causes production of a chimeric protein with advantageous features over that...
7041654 Methods and compositions for inducing tumor-specific cytotoxicity  
The present invention relates to the tumor-specific expression of heterologous polynucleotides, particularly genes encoding cytotoxic products, under the control of transcriptional regulatory...
7041653 Gene transcription and ionizing radiation: methods and compositions  
The present invention provides a DNA molecule comprising a radiation responsive enhancer-promoter operatively linked to an encoding region that encodes at least one polypeptide. An encoding region...
7037903 Method for using thymosin β-10 for gene therapy of solid malignant tumors  
A method for using thymosin β-10 for cancer treatment by expressing thymosin β-10 in solid malignant tumor cells. More precisely, the present invention relates to a cancer treatment method...
7037718 Mutant purine nucleoside phosphorylase proteins and cellular delivery thereof  
The present invention provides a procaryotic host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside phosphorylase or hydrolase. The...
Matches 501 - 550 out of 3179 < 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 >