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7037646 |
Amine-derivatized nucleosides and oligonucleosides
Nucleosides and oligonucleosides functionalized to include alkylamino functionality, and derivatives thereof. In certain embodiments, the compounds of the invention further include steroids,...
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7037506 |
Vaccine accelerator factor (VAF) for improvement of vaccinations in poultry
The present invention provides a vaccine accelerator factor (VAF) which is an in ovo nucleotide immuno-stimulant. The VAF contains one or more DNA constructs, each having a DNA molecule and a...
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7034010 |
Use of recombinant gene delivery vectors for treating or preventing lysosomal storage disorders
Gene delivery vectors, such as, for example, recombinant FIV vectors, and methods of using such vectors are provided for use in treating or preventing retinal diseases of the eye and diseases of...
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7034009 |
Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
The present invention relates to nucleic acid molecules such as ribozymes, DNAzymes, and antisense which modulate the synthesis, expression and/or stability of an mRNA encoding one or more...
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7034008 |
Cardiac arrhythmia treatment methods
Disclosed are methods of preventing or treating cardiac arrhythmia. In one embodiment, the methods include administering to an amount of at least one polynucleotide that modulates an electrical...
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7034007 |
Low adenosine anti-sense oligonucleotide, compositions, kit & method for treatment of airway disorders associated with bronchoconstriction, lung inflammation, allergy(ies) & surfactant depletion
An in vivo method of selectively delivering a nucleic acid to a target gene or mRNA, comprises the topical administration, e.g. to the respiratory system, of a subject of a therapeutic amount of an...
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7033834 |
Methods and means for targeted gene delivery
A method for producing viral gene delivery vehicles which can be transferred to pre-selected cell types by using targeting conjugates. The gene delivery vehicles comprise: 1) the gene of interest;...
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7033830 |
Antisense modulation of MyD88 expression
Antisense compounds, compositions and methods are provided for modulating the expression of MyD88. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted...
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7033829 |
Method to inhibit cell growth using oligonucleotides
Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising pTT or a...
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7033607 |
pH-titratable polyampholytes for delivering polyions to a cell
A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative...
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7030099 |
Tumor specific promoters of the midkine gene that allow for selective expression in P53-inactivated cells
A DNA comprising a 609 bp base sequence from −559 to +50 when the first base sequence of exon 1 of the midkine gene, a human retinoic acid-responsive growth/differentiation factor was set as +1,...
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7030098 |
DNA vaccination for treatment of autoimmune disease
A pro-inflammatory T cell response is specifically suppressed by the injection into a recipient of DNA encoding an autoantigen associated with autoimmune disease. The recipient may be further...
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7030097 |
Controlled nucleic acid delivery systems
One aspect of the present invention relates to a nucleic acid delivery system including a polymeric structure formed of a biocompatible polymer and a mixture comprising one or more nucleic acid...
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7030096 |
Method of enhancing relaxation of penile smooth muscle by introduction of DNA encoding maxi-K potassium channel protein
The present invention is directed towards a method of regulating smooth muscle tone, comprising the introduction, into smooth muscle cells of a subject, of a DNA sequence encoding a protein...
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7029845 |
DNAs and proteins or peptides specific to bacteria of the species Neisseria meningitidis, processes for obtaining them and their biological uses
The DNA of the invention are characterised in that they concern the whole or part of genes, with their reading frame, to be found in Neisseria meningitidis , but not in Neisseria gonorrhoeae , or...
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7029681 |
Multiple and multivalent DNA vaccines in ovo
The present invention provides a muliple DNA vaccine and/or a multivalent DNA vaccine for use in aquiring embroyonic immunity in fowl eggs. The multiple DNA vaccine contains two or more DNA...
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7029680 |
Delivery of immunogenic molecules vis HBsAg particles
Compositions of HBsAg particles having biologically active molecules contained in the particles, and methods of their use, e.g. in stimulating enhanced immune responses, are described. Antigenic...
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7029668 |
Stimulation of angiogenesis via enhanced endothelial expression of syndecan-4 core proteins
The present invention provides tangible means and methods for stimulation of angiogenesis via enhanced endothelial expression of core proteins having a syndecan-4 cytoplasmic region...
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7026301 |
Method of orally treating inflammatory skin conditions with prodrugs of 5-fluorouracil
The present invention relates to the treatment of inflammatory skin conditions, including psoriasis, with a prodrug of 5-fluorouracil. The invention relates to methods for treatment of psoriasis...
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7026300 |
One step immunization procedure for inducing a Chlamydia specific immune response
A host is immunized against infection by a strain of Chlamydia by initial administration of an attenuated bacteria harbouring a nucleic acid encoding a Chlamydia protein followed by...
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7026299 |
Connective tissue growth factor-2
The present invention relates to a human CTGF-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and...
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7026162 |
Lac shuttle vectors
The invention discloses a Lac shuttle vector, comprising at least (a) a region which regulates a plasmid copy number; (b) an eukaryotic gene expression cassette, which comprises at least an...
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7026156 |
Diagnostic and protective antigen gene sequences of ichthyophthirius
A novel i-antigen protein from Ichthyophthirius multifiliis is effective to induce a protective immune response in fish. The invention includes antigenic and membrane-targeting sequences of...
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7025987 |
Delivery system for nucleic acids
α v β 3 Integrin receptor targeting liposomes comprise a cationic amphiphile such as a cationic lipid, a neutral lipid, and a targeting lipid. The targeting lipid includes a non-peptidic α v β...
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7022525 |
Process of making a compound by forming a polymer from a template drug
A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for...
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7022320 |
Mycobacterium tuberculosis immunization
Recombinant nucleic acid molecules are described. The molecules have a sequence or sequences encoding at least two M. tuberculosis antigens. Vectors and compositions containing these molecules...
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7022319 |
Vectors carrying therapeutic genes encoding antimicrobial peptides for gene therapy
The present invention relates to recombinant vectors carrying sequences encoding naturally occurring antimicrobial peptides or derivatives thereof for the treatment of mammalian tumours and viral...
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7018984 |
Methods and compositions for controlling translation of HCV proteins
Embodiments of the present invention feature methods and compositions for controlling the translation of viral peptides and proteins from viral nucleic acid, with particular applications to...
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7018833 |
Linear and circular expression elements
The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention...
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7015205 |
Melanoma vaccine and methods of making and using same
An immunotherapeutic vaccine providing antigen presenting cells that have been pulsed with a disrupted cell preparation which includes enucleated cytosol and cell membranes of cancer cells infected...
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7015204 |
Protective immunity or immunological tolerance induced with RNA particularly total cellular RNA
Effective anti-tumor immunity is induced in mice utilizing RNA-pulsed epidermal cells (EC) for in vivo immunization or by injecting RNA intradermally into naïve mice. A vaccine comprising total...
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7015190 |
Method for enhancing long-term memory in a subject and uses thereof
The present invention provides for a method to enhance long-term memory in a subject whose cAMP-responsive gene expression is repressed due to binding of a cAMP-response-element-binding-protein-2...
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7015040 |
Intravascular delivery of nucleic acid
Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the...
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7014847 |
Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders
The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders,...
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7011973 |
Regulatory sequences capable of conferring expression of a heterologous DNA sequence in endothelial cells in vivo and uses thereof
Described are recombinant DNA molecules comprising the regulatory sequences of an intron of the Endothelial Growth Factor (VFGF) receptor-2 gene (Flk-1) or of a gene homologous to the Flk-1 gene,...
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7011960 |
Substituted 2-amino-3-(2-amino-phenylsulfanyl)-propionic acids
The present invention relates to a new process for the preparation compounds of formula I
wherein R 1 , R 2 , R 3 and n are as described in the description which process comprises reacting...
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7008791 |
Liposome-entrapped DNA oral vaccines
An oral vaccine contain liposomes and complexed or, preferably entrapped, DNA operatively encoding an antigen in which the liposomes are formed from components including cationic compounds and...
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7005425 |
Method for treating arrhythmias
Methods are provided for treating arrhythmia in a manner that minimizes undesirable side effects, comprising administration of a therapeutically effective minimal dose of an A 1 adenosine receptor...
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7005424 |
Nucleic acid encoding an E1A gene product sensitizes HER-2/neu overexpressing cancer cells to chemotherapy
The present invention relates to methods for the inhibition, of the gene product of the neu oncogene, p185neu tyrosine kinase. Over-expression of the neu oncogene leads to chemoresistance. The...
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7005423 |
Characterization of gene function using double stranded RNA inhibition
There is provided a method of identifying DNA responsible for conferring a particular phenotype in a cell which method comprises a) constructing a cDNA or genomic library of the DNA of the cell in...
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7005300 |
Polyhydroxy diamine surfactants and their use in gene transfer
The use of carbohydrate-based surfactant compounds having the general formula (I):
wherein Y 1 and Y 2 , which may be the same or different, are carbohydrate groups;
R 1 and R 2 , which may...
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7005140 |
Lipid particles having asymmetric lipid coating and method of preparing same
A method of preparing lipid particles having an asymmetric lipid coating is described. The lipid composition of the outer lipid coating of the particles varies from the inner to outer surfaces. The...
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7005139 |
Compositions and methods for the targeted delivery of agents to treat liver cancer
The invention provides compositions containing an effective amount of a therapeutic agent encapsulated in a liposome coupled to a desialyated glycoprotein, e.g., desialyated glycoprotein-α1. This...
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7005127 |
Mixed-cell gene therapy
The subject invention is directed to a mixed cell composition to generate a therapeutic protein at a target site by providing a first population of mammalian cells transfected or transduced with a...
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7005126 |
Method for tumor treatment using infusion of xenogeneic cells to induce hyperacute rejection and innocent bystander effect
A method for treating tumors. Through infusion or xenotransplantation of xenogeneic cells, such as infusion of murine cells into the peritoneal cavity of humans, a hyperacute rejection response to...
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7001891 |
Biodegradable polycation composition for delivery of an anionic macromolecule
The present invention provides a biodegradable polycation composition for delivery of an anionic macromolecule, comprising a polysaccharide chain having an amount of saccharide units ranging from 2...
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7001890 |
Pharmaceutical compositions comprising a polynucleotide and optionally an antigen especially for vaccination
The present invention relates to pharmaceutical compositions comprising at least one fragment of a polynucleotide, preferably at least one antigen, and optionally a pharmaceutically acceptable...
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7001760 |
Hepatitis B virus vectors for gene therapy
The present invention relates to novel hepatitis B virus vectors for use in gene therapy which can deliver therapeutic genes to liver cells. The invention also provides methods for the production...
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7001759 |
Compositions and methods for delivery of genetic material
Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an...
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6998268 |
Gene preparations
The present invention relates to gene preparations comprising desired genes or vectors containing desired genes integrated there into and carriers for supporting the same. The carrier is preferably...
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