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7375093 |
Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain;...
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7375092 |
Lunasin peptides
The invention provides methods and compositions of selectively disrupting mitotic function in a target cell demonstrating undesirable mitotic function. Suitable target cells include mammalian,...
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7375091 |
HER-2/neu fusion proteins
The present invention is generally directed to HER-2/neu fusion proteins, nucleic acid molecules encoding HER-2/neu fusion proteins, viral vectors expressing HER-2/neu fusion proteins, and...
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7374931 |
Vaccine against staphylococcus intoxication
Using nucleic acids encoding mutant SEA and SEB exotoxins from Staphylococcus aureus , compositions and methods for use in inducing an immune response which is protective against staphylococcal...
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7371736 |
Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss
Gene expression profiling reveals four distinct subgroups of multiple myeloma that have significant correlation with various clinical characteristics. Diagnosis for multiple myeloma (and possibly...
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7371735 |
Inhibitor oligonucleotides and their use for specific repression of a gene
A method of treating a disease resulting from the expression of a harmful gene is described. The method includes the step of administering a therapeutically effective amount of a pharmaceutical...
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7371734 |
Oligonucleotide compositions and their use for the modulation of immune responses
The present invention relates to 3′-OH, 5′-OH polynucleotide sequence compositions and methods for activating an immune response in an individual, and more preferably, for activating antigen...
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7371524 |
Substituted azaporphyrins as fluorescence labels
The present invention relates to marker components, fluorescent probes, oligonucleotides, hybridization assays, and immunoassays using such products, and methods for making such products. According...
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7371387 |
Vaccine compositions and methods of modulating immune responses
The invention provides compositions and methods for modulating immune responses in subjects. The invention is based, at least in part, on the discovery that an in-frame translation fusion of an...
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7368436 |
TRPM-2 antisense therapy
It has been determined that antisense therapy which reduces the expression of TRPM- 2 provides therapeutic benefits in the treatment of cancer, particularly prostate and renal cell cancers....
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7368420 |
Akt compositions for enhancing survival of cells
This invention relates to methods and compositions for the treatment of apoptotic cell-death. In particular the invention relates to Akt molecules and their use in inhibiting apoptotic cell-death...
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7365058 |
MicroRNA and methods for inhibiting same
The invention relates to isolated DNA or RNA molecules comprising at least ten contiguous bases having a sequence in a pancreatic islet microRNA. In another embodiment, the invention relates to...
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7364887 |
Use of PAK inhibitor for the treatment of a joint disease
The invention refers to the use of a p21-activated kinase (PAK) inhibitor for the treatment of a joint disease such as osteoarthritis or rheumatoid arthritis or for the treatment of a joint pain...
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7364725 |
Endothelial cells engineered to express or overexpress fibulin-5 and a growth factor
The present invention relates to endothelial and smooth muscle cells genetically altered to express or over-express one or more cell adhesion factors. The invention further relates to cells...
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7361642 |
Canine specific growth hormone releasing hormone
A composition and a method of increasing growth hormone (“GH”) values in a canine or dog, and more specifically, a canine- or dog-specific growth hormone releasing hormone (“dGHRH”), or...
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7361641 |
Methods and compositions for genomic modification
The present invention provides methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell, as well as, enzymes, polypeptides, and a variety of...
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7361640 |
Stable lipid-comprising drug delivery complexes and methods for their production
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
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7361639 |
Gene therapy agent for Haemophilia B and its preparation method
The invention relates to site-specific integrating expression vectors for therapy Hemophilia B and to methods of preparing them. A vector of the invention contains a human Factor IX gene in a...
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7358234 |
Induction of a protective immune response through microprojectiles coated with a DNA sequence encoding an immunogenic protein
The present invention relates to a process for inducing a protective immune response in a mammal against a virus, in which a construct including a promoter and a DNA sequence encoding a protein or...
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7358223 |
Biodegradable cationic polymers
Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells.
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7357941 |
Method of delivering a bioactive agent with porous β-tricalcium phosphate granules
A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter...
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7354909 |
Method for rapid generation of mature dendritic cells
Novel methods for rapidly generating dendritic cells are disclosed herein. The methods include contacting a dendritic cell precursor with a D ODN to generate a mature dendritic cell. In one...
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7354908 |
Materials and methods for prevention and treatment of RNA viral diseases
The subject invention concerns a method of inhibiting an RNA virus infection within a patient by increasing the amount of 2-5 oligoadenylate synthetase (2-5 AS) activity within the patient....
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7354907 |
Short immunomodulatory oligonucleotides
The invention relates to modulation of the immune system. More particularly, the invention relates to modulating the immune system through the use of oligonucleotide-derived compounds. The...
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7354894 |
Preventing airway mucus production by administration of EGF-R antagonists
Hypersecretion of mucus in the lungs is inhibited by the administration of an epidermal growth factor receptor (EGF-R) antagonist. The EGF-R antagonist may be in the form of a small organic...
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7354759 |
DNA vaccines expressing hypervariable VH-CDR3 idiotypic determinants
The present invention relates to a method for inducing the immune response of an individual against B-lymphoproliferative disorders. The method is based on DNA vaccination with the short peptide...
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7351697 |
Tumor-specific vector for gene therapy
The invention relates to a vector for the gene therapeutic treatment of tumors, especially in connection with radiotherapy. Said vector is provided with a therapeutic gene in the DNA sequence...
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7351579 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Circovirus sequences associated with piglet weight loss disease (PWD)
The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and...
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7348314 |
Compositions and methods for inhibiting viral replication
The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least...
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7348173 |
Fatty-acid amide hydrolase
The soporific activity of cis-9,10-octadecenoamide and other soporific fatty acid primary amides is neutralized by hydrolysis in the presence of fatty-acid amide hydrolase (FAAH). Hydrolysis of...
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7347998 |
Method of delivering therapeutic agents to site of tissue injury
A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds...
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7345027 |
Compositions and methods for siRNA inhibition of angiogenesis
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these...
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7345026 |
Hybrid or chimeric polynucleotides, proteins, and compositions comprising hepatitis B virus sequences
H-2 class I negative, HLA-A2.1 transgeniic HHD mice were used for a comparative evaluation of the immunogenicity of HLA-A2.1 restricted human tumor-associated CTL epitopes. A hierarchy was...
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7345025 |
Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells
Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of...
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7344887 |
Methods and products for delivering biological molecules to cells using multicomponent nanostructures
This invention is predicated on the present applicants' discovery that nanostructures comprising discrete regions of different composition can be used to deliver to a biological cell a desired...
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7344844 |
Compositions and methods of using apoptosis signaling kinase related kinase (ASKRK)
The invention provides apoptosis signaling kinase related kinase (ASKRK) nucleic acid and polypeptide sequences and methods of using such sequences to identify modulators of ASKRK. Such modulators...
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7342002 |
Molecular vaccine linking an endoplasmic chaperone polypeptide to an antigen
This invention provides compositions and methods for inducing and enhancing immune responses, such as antigen-specific cytotoxic T lymphocyte (CTL) responses, using chimeric molecules comprising...
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7341871 |
Nucleotide sequences for gene regulation and methods of use thereof
The invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest. In particular, the invention provides nucleic acid sequences which regulate expression...
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7341738 |
Lipid-encapsulated polyanionic nucleic acid
Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino...
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7341718 |
Neuronal gene transfer of adenovirus and herpes virus vectors
The present invention is related to compositions and methods for the delivery of nucleic acids to neurons in a mammal, and uses thereof. The present invention specifically discloses the use of...
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7338777 |
Method for determining the biological activity of defibrotide
Method for determining the biological activity of defibrotide by a) bringing into contact defibrotide, plasmin and a substrate specific for the plasmin which, by reaction with the plasmin, provides...
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7338655 |
Gene therapy using TGF-β
The subject invention is related to a cell-mediated gene therapy treatment for orthopedic disease using a member belonging to the transforming growth factor-β (TGF-β) superfamily. TGF-β gene...
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7335647 |
Drugs for liver diseases
Preventives and/or remedies for liver diseases, which comprise monocyte chemoattractant protein-I (MCP-I) function inhibitors as active ingredients, respectively. Administration of the MCP-I...
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7335646 |
Compositions and methods for regulated protein expression in gut
The invention provides compositions and methods useful for treating disorders treatable by producing a protein in a regulatable manner in a mucosal cell or tissue of an animal. The treatment...
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7335509 |
Stable lipid-comprising drug delivery complexes and methods for their production
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes...
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7335384 |
Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith
The present disclosure describes a novel composition for the treatment and/or prevention of neurogenic inflammation. Such composition is also useful in the treatment and/or prevention of disease...
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7335353 |
Porcine cells comprising an adenovirus E3 gene region
The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3) is provided. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells...
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7332478 |
Antitumoral composition based on immunogenic polypeptide with modified cell location
Antitumoral compositions can comprise as therapeutic agent one or several immunogenic polypeptides, of which at least one is modified so as to have a cell location different from its native...
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7332477 |
Photocleavable DNA transfer agent
The present invention provides visible light sensitive and ultraviolet (UV) light sensitive composition for DNA transfer comprising acid sensitive polyacetals developed as DNA/RNA delivery agents,...
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7332337 |
Viral vectors having tissue tropism for T-lymphocytes, B- and mast cells
The present invention relates to methods of introducing an expressible non-viral nucleic acid sequence into a T lymphocyte cell, a B-cell, or a mast cell, comprising contacting the cell with a...
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