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7332165 |
Antibody production in farm animals
The present invention provides means and methods for obtaining an antibody in a mammary secretion product of a farm-animal comprising administering to said animal at least two compositions, which...
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7329650 |
Peptides and peptide analogues designed from HFE protein and their uses in the treatment of iron overload diseases
The present invention relates to peptides and peptide analogues designed from HFE protein. In particular, it relates to peptides and peptide analogues designed from an alpha-1 region of HFE protein...
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7329649 |
Combinatorial methods for inducing cancer cell death
The present invention relates to methods and compositions for inhibiting proliferation and inducing cell death in a population of cancer cells by (i) increasing the amount of the differentiation...
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7329648 |
Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
The invention provides methods for modulating the immune response caused by CpG-containing oligonucleotides. The methods according to the invention enable both decreasing the immunostimulatory...
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7326693 |
Antisense modulation of c-reactive protein expression
Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense...
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7326692 |
Induction of immunity using inhibitors of granzymes
The present invention provides methods for enhancing host immunity to a virus and/or a cancer and methods for enhancing the cytotoxic T-cell (CTL) mediated immune responses by providing granzyme B...
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7323450 |
Complex immuno-gene medical composition for inhibiting tumor cells
Disclosed is a complex immuno-gene medical composition for activating NK cells to enhance a host immune system. The composition includes a plurality of cytokines, including Th1 and Th2 cytokines....
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7323297 |
Stabilized polynucleotide complexes and methods
The invention comprises stabilized polynucleotide complexes that have a cryoprotectant and are lyophilized. Cryoprotectant compounds comprise carbohydrates or sugars, preferably lactose and...
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7320965 |
Compositions and methods for inhibiting expression of Huntingtin gene
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Huntingtin gene (HD gene), comprising an antisense strand having a nucleotide sequence which...
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7320964 |
Modulation of expression of STAT-1 dependent genes
The invention relates to decoy oligonucleotides and antisense oligonucleotides comprising a nucleic acid sequence according to SEQ ID NO: 1 to 43, in addition to the use of said nucleotides as...
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7320963 |
Methods and compositions for delivery of pharmaceutical agents
Methods and compositions for delivering pharmaceutical agents into cells, in particular urothelial cells of the bladder, are provided. In the methods and compositions of the invention, a...
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7319094 |
Increased and sustained in vivo gene expression using a nucleic acid, histone and amphipathic compound composition
The invention features a non-transgenic model of Alzheimer's Disease, method for inducing prolonged in vivo gene expression in a mammal, and methods of inhibiting Alzheimer's Disease-associated...
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7317004 |
Compositions and methods for elimination of unwanted cells
Disclosed are compositions comprising a recombinant nucleic acid vector including a nucleotide sequence encoding a syncytium-inducing polypeptide expressible on a eukaryotic cell surface, and a...
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7316925 |
Codon optimized synthetic plasmids
One aspect of the current invention is an optimized synthetic mammalian expression plasmid (e.g. pAV0201). This new plasmid comprise a therapeutic element, and a replication element. The...
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7314869 |
Chlamydia antigens and corresponding DNA fragments and uses thereof
The present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia , specifically C....
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7314868 |
Compositions and methods for elimination of unwanted cells
Disclosed are compositions comprising a recombinant nucleic acid vector including a nucleotide sequence encoding a syncytium-inducing polypeptide expressible on a eukaryotic cell surface, and a...
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7314627 |
Cationic lipid-mediated enhancement of nucleic acid immunization of cats
The present invention relates to a method to introduce a nucleic acid molecule into a felid by administration of a nucleic acid-cationic lipid complex composition. The method includes the step of...
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7314614 |
Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
Provided are a recombinant Sendai virus vector for introducing exogenous genes to airway epithelia and a method for introducing exogenous genes using the vector. The recombinant Sendai virus vector...
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7312202 |
Rationally designed and chemically synthesized promoter for genetic vaccine and gene therapy
The present invention relates to chemically synthesized promoters that circumvent the disadvantages of the universal CMV promoter/enhancer elements. The promoter may be used in a variety of...
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7309695 |
Pharmaceutical compositions for the prevention and treatment of atherosclerosis and restenosis after PTCA
The present invention provides a pharmaceutical composition for the prevention or treatment of angiostenosis, comprising a compound inhibiting the function of midkine (MK) in blood vessel tissues...
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7309694 |
Modified cytokines for use in cancer therapy
Cytokine derivatives capable of homing the tumoral vessels and the antigen presenting cells and the use thereof as antitumoral agents.
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7309693 |
Preventives and remedies for pulmonary hypertension
The present invention provides a prophylactic and/or therapeutic agent for pulmonary hypertension, comprising an antagonistic mutein of MCP-1 or a salt thereof, a DNA molecule comprising a...
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7309692 |
Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1
The present invention provides novel compositions and methods for use in the treatment of cancer, specifically, in the treatment of chronic myelogenous leukemia (CML). The compositions contain...
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7309567 |
Method for reducing fluorescence quenching in bioassays
The invention relates to a process for reducing the fluorescence quenching caused by the measuring medium, in a fluorescence assay for an analyte using at least one fluorescent label, characterized...
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7307069 |
Antisense oligonucleotide modulation of STAT3 expression
Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods...
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7307068 |
Use of rapamycin to inhibit immune response and induce tolerance to gene therapy vector and encoded transgene products
Disclosed are methods for transient co-administration of rapamycin together with a gene therapy vector encoding a transgene. The present invention is directed to inhibiting the immune response of a...
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7307067 |
Methods and compositions for reducing viral genome amounts in a target cell
Methods and compositions for reducing viral genome amounts in a target cell are provided. In the subject methods, the activity of a miRNA is inhibited in a manner sufficient to reduce the amount of...
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7307066 |
Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
Aspects of the present invention relate to the discovery of a novel hepatitis C virus (HCV) isolate. Embodiments include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed...
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7307065 |
2′-Fluoronucleosides
A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including...
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7306902 |
Oncolytic viruses as phenotyping agents for neoplasms
The present invention provides a method of diagnosing neoplasms having a particular phenotype by using oncolytic viruses that selectively replicate in neoplasms having the particular phenotype. For...
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7304042 |
Potent inhibition of influenza virus by specifically designed short interfering RNA
This patent application discloses siRNA sequences against the constant region of the ,8 influenza virus nucleoprotein gene comprising:
(SEQ ID NO: 1) Sense strand: 5′ UGAAGGAUCUUAUUUCUUCdTdT...
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7304041 |
Modulators of coagulation factors
The invention provides improved nucleic acid ligands that inhibit coagulation and improved modulators of the nucleic acids to provide ideal modulators of coagulation. These improved nucleic acids...
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7304040 |
Suppression of post-transplant arteriosclerosis
A preventive and/or therapeutic agent for post-transplant arteriosclerosis occurring as a rejection response to organ transplantation or for auto- or allo-arteriovenous graft post-transplant...
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7303910 |
Retroviral vectors comprising a functional splice donor site and a functional splice acceptor site
A retroviral vector is described. The retroviral vector comprises a functional splice donor site and a functional splice acceptor site; wherein the functional splice donor site and the functional...
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7300922 |
Modulators of pharmacological agents
The biological activity of nucleic acid ligand is regulated (i.e. enhanced or inhibited) in vivo to produce a desired biological effect. This is accomplished through the administration of a...
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7300657 |
Recombinant viral-based malaria vaccines
The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alpha viruses, adenoviruses or vaccinia viruses. The recombinant viral-based...
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7297685 |
Use of pro-apoptotic factors in treatment of atherosclerosis
The present invention features a novel method of treating vascular disease that involves modifying smooth muscle cells to express a gene encoding a protein having both anti-inflammatory and...
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7297684 |
Antisense therapy for hormone-regulated tumors
A method is provided for treating hormone-regulated tumors (for example, breast and prostatic tumors) in mammals, including humans, by administration of an antisense ODN which is complementary to a...
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7297542 |
Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob
The present invention provides means to modify the tropism of recombinant adenoviral vectors using genetic methods to alter the adenoviral fiber cell-binding protein. The present invention...
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7297535 |
Use of the human LRP/MVP promotor for a vector that can be induced by therapy
Embodiments of the invention relate to a vector system that allows one to induce expression of therapeutically relevant genes in mammalian cells. Such a vector system may be useful for medicine and...
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7297475 |
Medicament injection kit and medicament injection method
A medicament injection kit, for use in occluding a renal artery and a renal vein in a kidney and injecting a therapeutic medicament into the kidney so as to pressurize the kidney, includes: an...
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7297341 |
Chlamydia antigens and corresponding DNA fragments and uses thereof
The present invention provides purified and isolated polynucleotide molecules that encode Chlamydia polypeptides which can be used in methods to prevent, treat, and diagnose Chlamydia ...
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7294505 |
Stable episomal vectors
The present invention provides a vector system which can be stably translocated from the cytoplasm of a cell to the nucleus where it is a stable nuclear episomal vector. A basic vector system...
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7294496 |
Cloned human lysophospholipase
A cloned of a human brain lysophospholipid-specific lysophospholipase enzyme molecule, its potential use for treatment of a host of diseases and method of inactivation are disclosed. Also disclosed...
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7294338 |
Polynucleotide vaccine formula against canine pathologies, in particular respiratory and digestive pathologies
Disclosed is an immunological or vaccine composition that includes at least one plasmid that contains and expresses in vivo in host canine cells a nucleic acid molecule that encodes an antigen of a...
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7291605 |
Methods of treating various cancers using melanoma differentiation associated protein-7
This invention provides a method for reversing the cancerous phenotype of a cancer cell by introducing a nucleic acid having the melanoma differentiation associated gene (mda-7) into the cell under...
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7291604 |
Methods of treating restenosis
Restenosis in a subject can be treated by administering to a tissue, e.g., a blood vessel, of the subject an agent that increases SERCA activity. For example, a stent that is coated with the agent...
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7288531 |
Potent inhibition of influenza virus by specifically designed short interfering RNA
This patent application discloses siRNA sequences against the constant region of the influenza virus nucleoprotein gene comprising:
Sense strand: 5′ UGAAGGAUCUUAUUUCUUCdTdT 3′ (SEQ ID NO: 1)...
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7288530 |
Antisense modulation of survivin expression
Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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7288529 |
ALK protein tyrosine kinase, cells and methods embodying and using same
The present invention provides for a transgenic animal model that constitutively expresses a protein encoded by the NPM-ALK gene in lymphoid tissue, and exhibits enhanced and accelerated...
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