Matches 251 - 300 out of 3179 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >
Match Document Document Title
7247620 Method of treating skin wounds with vectors encoding hepatocyte growth factor  
The present invention relates to a therapeutic preventive agent that includes an angiogenic factor gene (such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF),...
7247619 Viral vectors useful in induction of humoral or cellular immunity  
The invention features recombinant viral vectors that take advantage of the activity of picornaviral protein 3A in modulating cytokine secretion and antigen presentation on MHC Class I (MHC I),...
7247618 Methods for inhibiting macrophage colony stimulating factor and c-FMS-dependent cell signaling  
Described herein are methods of inhibiting M-CSF activity, and, in particular, M-CSF/c-fms dependent cell signaling. In a first embodiment of the invention, one administers to a mammal viral...
7247439 Method of evaluating a patient antibody response to envelope proteins of a virus  
The invention provides a method for identifying whether a compound inhibits entry of a virus into a cell which comprises: (a) obtaining nucleic acid encoding a viral envelope protein from a patient...
7247288 Method of manufacturing hydroxyapatite and uses therefor in delivery of nucleic acids  
Provided is a method for production of nanocrystalline hydroxyapatite particles, and nanocrystalline hydroxyapatite particles produced according to the method. The nanocrystalline hydroxyapatite...
7244715 Vaccines containing ribavirin and methods of use thereof  
Compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans are disclosed. More particularly, vaccine compositions comprising...
7244714 Methods of delivering aerosolized polynucleotides to the respiratory tract  
Methods and devices for delivering aerosolized formulations containing polynucleotides to specified regions within a subject's respiratory tract are disclosed. The methods find use in the delivery...
7244438 Uses for polycationic compounds  
The invention relates to the use of a polycationic compound for the preparation of a medicament with retarded in vivo release.
7244423 Methods for therapy of neurodegenerative disease of the brain  
A specific clinical protocol for use toward therapy of defective, diseased and damaged cholinergic neurons in the mammalian brain, of particular usefulness for treatment of neurodegenerative...
7244422 Vaccines containing ribavirin and methods of use thereof  
The present invention relates to compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans. More particularly, the use of...
7241744 Treating anemia in subjects by administration of plasmids encoding growth hormone releasing hormone  
The present invention pertains to compositions and methods for plasmid-mediated supplementation. The compositions and method are useful for retarding the growth of the tumor, and retarding...
7241743 Sir2α-based therapeutic and prophylactic methods  
This invention provides methods for treating and for inhibiting the onset of cancer in a subject comprising administering an agent that inhibits the ability of Sir2α to inhibit p53-dependent...
7241742 CYP1B1 nucleic acids and methods of use  
The present invention provides nucleic acids containing transcriptional units that encode CYP1B1 polypeptides or portions thereof, wherein the transcriptional units lack sequences found in the...
7241618 Expression system  
The present invention provides a polynucleotide comprising a RNA polymerase III promoter, a region encoding a siRNA, and a transcriptional termination element comprising five consecutive thymine...
7241617 Sendai viral vectors comprising foreign genes inserted between the R1 and R2 Loci  
Use of a negative-sense RNA virus vector has enabled transfer of nucleic acid into nerve cells. The method of this invention can be used for introducing a gene efficiently into nerve cells...
7241596 Methods and reagents for combined PCR amplification and hybridization probing  
An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite...
7241440 Vaccines containing ribavirin and methods of use thereof  
Compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans are disclosed. More particularly, vaccine compositions comprising...
7238675 Antisense antibacterial method and composition  
The invention relates to compositions comprising oligomers antisense to bacterial 16S or 23S rRNA and capable of selectively modulating the biological activity thereof, and methods for their use....
7238674 Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors  
The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue is disclosed. The invention allows for the direct, in vivo injection of...
7238673 Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor  
A method for the direct in vivo transformation of cells in and surrounding a solid tumor is disclosed. This method is based on the site-specific delivery of proteins to solid tumors and to tissue...
7238672 Chimeric lyssavirus nucleic acids and polypeptides  
The present invention provides chimeric nucleic acids, preferably contained on an expression vector, that encode chimeric immunogenic polypeptides. The nucleic acids encode at least site III of a ...
7238346 High capacity recombinant adenoviral vector for treatment of hemophilia A  
The invention relates to adenoviral vectors. More particularly, this invention relates to recombinant high capacity adenoviral vectors which can be employed in the treatment of hemophilia A, as...
7235534 Antisense strategy to modulate estrogen receptor response (ER α and/or ER β )  
The present invention provides novel antisense oligonucleotides that target the genes and mRNAs encoding mammalian Estrogen Receptors (ER) alpha and/or beta and modulate the receptors' responses....
7235236 Polynucleotide encoding human adenylylcyclase VI and uses thereof for enhancing cardiac function  
The present invention relates to polynucleotides encoding human adenylylcyclase VI and uses thereof for enhancing cardiac function. The present invention can thus be used in the treatment of heart...
7235233 Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts  
The invention provides means and methods for transduction of a skeletal muscle cell and/or a muscle cell specific precursor thereof. Provided is the use of a gene delivery vehicle derived from an...
7232808 Methods of inhibiting manganese-containing superoxide dismutase 2 (MnSOD)  
The present invention provides RNA molecules (e.g., antisense, RNAi, or siRNA) specific for MnSOD, and further provides methods of reducing expression of MnSOD in cells (e.g., cancer cells).
7232807 Compositions and methods for binding agglomeration proteins  
Amplibody compositions and methods used to interact with agglomeration proteins are disclosed herein. Compositions herein comprise one or more DNA or RNA molecules having affinity for at least one...
7232806 MicroRNA molecules  
In Caenorhabditis elegans , lin-4 and let-7 encode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing. Because the appearance of these short RNAs is...
7232682 Expression vectors encoding epitopes of target-associated antigens and methods for their design  
The invention disclosed herein is directed to methods of identifying a polypeptide suitable for epitope liberation including, for example, the steps of identifying an epitope of interest; providing...
7229976 Modulation of forkhead box O1A expression  
Antisense compounds, compositions and methods are provided for modulating the expression of forkhead box O1A. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
7229975 DNA immunization against chlamydia infection  
Nucleic acid, including DNA, immunization is used to generate a protective immune response in a host, including humans, to a serine-threonine kinase (STK) of a strain of Chlamydia . A...
7229974 G cap-stabilized oligonucleotides  
Oligonucleotides of the formula 5′-(CAP)-(Oligo)-(CAP)-3′ are disclosed...
7229959 Supplemented fibrin matrix delivery systems  
This invention provides supplemented and unsupplemented tissue sealants as well as methods for their production and use thereof. Disclosed are tissue sealants supplemented with at least one...
7226912 Hepatitis C virus non-structural NS3/4A fusion gene  
Disclosed herein is the discovery of a novel hepatitis C virus (HCV) isolated from a human patient. Embodiments of the invention include HCV peptides, nucleic acids encoding said HCV peptides,...
7223743 Hepatitis C virus codon optimized non-structural NS3/4A fusion gene  
Aspects of the present invention relate to the discovery of a novel hepatitis C virus (HCV) isolate. Embodiments include HCV peptides, nucleic acids encoding said HCV peptides, antibodies directed...
7223742 Enhanced solubility of recombinant proteins  
Disclosed are methods for improving the solubility of a protein of interest produced recombinantly by expressing the protein of interest as a fusion protein with a member of the 14-3-3 family of...
7223741 Immunostimulatory nucleic acid molecules  
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity,...
7223740 Vectors for enhanced expression of VEGF for atrial disease treatment  
The invention provides a vector which is capable of the expression of a vascular endothelial growth factor wherein the vector comprises a modified PCMV promoter. The invention further provides use...
7223739 Adjuvanted genetic vaccines  
Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for...
7223600 Photochemical internalization for delivery of molecules into the cytosol  
The present invention provides a method for introducing a molecule into the cytosol of a cell in which the cell is contacted with a photosentistising agent, the cell is irradiated with light of a...
7223406 Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder  
The invention provides a method for preventing or treating male erectile dysfunction or female sexual arousal disorder by administering an effective amount of one or more factors from a group of...
7220728 Methods of inducing mucosal immunity  
Methods of inducing mucosal immunity in individuals against proteins and peptides are disclosed. The methods comprise the step of administering topically or by lavage into mucosal tissue selected...
7220575 Melanoma differentiation associated gene-5 and promoter and uses thereof  
The invention provides for an isolated nucleic acid encoding Mda-5 (melanoma differentiation associated gene-5) and an isolated Mda-5 polypeptide. The invention further provides a vector comprising...
7220423 DNA immunization against Chlamydia infection  
Nucleic acid, including DNA, for immunization to generate a protective immune response in a host, including humans, to a major outer membrane protein of a strain of Chlamydia , preferably contains...
7217700 Chemokines as adjuvants of immune response  
Dendritic cells play a critical role in antigen-specific immune responses. Materials and methods are provided for treating disease states, including cancer and autoimmune disease, by facilitating...
7217699 Compositions comprising genome segments and methods of using the same  
Methods of treating an individual who has a disease or disorder associated with one or more genetic mutations or undesirable alleles in genomic DNA of the individual, or preventing an individual...
7217571 Gene therapy by small fragment homologous replacement  
A method for gene therapy using small fragment homologous replacement. The method introduces small fragments of exogenous DNA into regions of endogenous genomic DNA virtually homologous to the...
7214368 Therapeutic regimen for treating cancer comprising the administration of adenoviral vectors comprising a TNF-α transgene  
The invention provides a method for treating a tumor in a human comprising administering to the tumor a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and...
7211569 Synthetic human papilloma virus genes  
Synthetic DNA molecules encoding papillomavirus proteins are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as...
7211558 Compositions and methods for the treatment of hemophilia A  
Improved materials and methods for the treatment of Hemophilia A are provided.
Matches 251 - 300 out of 3179 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >