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7211414 |
Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for...
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7208478 |
Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
Immunostimulatory polynucleotide-immunomodulatory molecule conjugate compositions are disclosed. These compositions include a polynucleotide that is linked to an immunomodulatory molecule, which...
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7208313 |
Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
A composition of matter comprising a vaccinia virus expression vector with a negative thymidine kinase phenotype and a negative vaccinia virus growth factor phenotype.
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7208267 |
Compositions and methods relating to breast specific genes and proteins
The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids...
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7205283 |
Antisense oligonucleotides that inhibit expression of HIF-1
New antisense oligonucleotide compounds, RX-0047 and RX-0149, inhibit expression of HIF-1 and also induce cytotoxicity in several cancer cell lines.
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7205282 |
Remedies for hepatitis
The object of the present invention is to provide a novel medicinal agent useful in the treatment or the prevention of hepatitis. The present invention is, for example, a therapeutic or preventive...
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7205280 |
Methods of suppressing microglial activation
Methods of suppressing the activation of microglial cells in the Central Nervous System (CNS), methods of ameliorating or treating the neurological effects of cerebral ischemia or cerebral...
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7204982 |
Compositions and methods for treatment and detection of multiple cancers
The invention provides a method for inhibiting proliferation of cancer cells, as well as methods for detecting and treating various cancers, including cancer of the brain, lung, breast, prostate...
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7202228 |
Hydrogelation agents
A gelatinizer is provided having a component which promises to have biological compatibility, which can easily be mass-produced by a simple method, and which can solidify a large amount of water or...
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7202227 |
Multifunctional molecular complexes for gene transfer to cells
A multifunctional molecular complex for the transfer of a nucleic acid composition to a target cell is provided The complex is comprised of A) said nucleic acid composition and B) a transfer moiety...
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7202226 |
Augmentation of wound healing by elF-4E mRNA and EGF mRNA
There is provided a method of augmenting transient protein synthesis in a cell by delivering to the cell mRNA functionally related to protein production. Also provided is a method of augmenting...
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7202225 |
Therapeutic delivery compositions and methods of use thereof
The present invention relates to compositions and methods for delivery of antisense oligonucleotides or other nucleic acid sequences. The present invention comprises a delivery composition...
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7201911 |
Cloned genomes of infectious hepatitis C viruses and uses thereof
The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the...
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7201910 |
Nucleic acid and amino acid sequences of infectious salmon anaemia virus and their use as vaccines
The present invention provides the use of nucleic acid sequences and/or amino acid sequences in the preparation of a vaccine for the protection of fish against infectious salmon anaemia virus....
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7199109 |
Potent inhibition of influenza virus by specifically designed short interfering RNA
This patent application discloses siRNA sequences against the constant region of the influenza virus nucleoprotein gene comprising:
Sense strand: 5′ UGAAGGAUCUUAUUUCUUCdTdT 3′ (SEQ ID NO: 1)...
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7199108 |
Nucleic acid and amino acid sequences of infectious salmon anaemia virus and their use as vaccines
The present invention provides the use of nucleic acid sequences and/or amino acid sequences in the preparation of a vaccine for the protection of fish against infectious salmon anaemia virus....
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7199107 |
Antisense modulation of kinesin-like 1 expression
Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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7198920 |
HER-2/neu fusion proteins
The present invention is generally directed to HER-2/neu fusion proteins, nucleic acid molecules encoding HER-2/neu fusion proteins, viral vectors expressing HER-2/neu fusion proteins, and...
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7196070 |
Prophylactic and therapeutic treatment of the ductal epithelium of a mammary gland for cancer
The present invention provides prophylactic and therapeutic methods of treating the ductal epithelium of an exocrine gland, in particular a mammary gland, for disease, in particular cancer. The...
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7196069 |
High affinity RNA ligands of basic fibroblast growth factor
Methods are described for the identification and preparation of nucleic acid ligand solutions to basic fibroblast growth factor (bFGF). Included in the invention are nucleic acid ligands to bFGF...
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7196068 |
Method for treating cancer using p38/JTV-1 and method for screening pharmaceutical composition for treating cancer
The present invention relates to a method for treating cancer using p38/JTV-1 and a method for screening pharmaceutical composition for treating cancer. More particularly, this invention relates to...
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7196067 |
Antisense insulin-like growth factor binding protein (IGFBP)-2-oligodeoxynucleotides for prostate and other endocrine tumor therapy
Compositions and a method are provided for the treatment of prostate and other endocrine tumors in mammals, including humans, by administration of an antisense oligodeoxynucleotide (ODN) which is...
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7196066 |
DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
Methods of eliciting an immune response in a subject by administering one or more large genomic DNA fragments are provided. Also provided are methods of identifying sequences encoding antigenic...
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7192936 |
Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and...
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7192935 |
Polynucleotides encoding epithelium-derived T-cell factor and uses thereof
Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for...
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7192934 |
Vaccines for blocking transmission of Plasmodium vivax
The present invention relates to novel methods and compositions for blocking transmission of Plasmodium vivax which cause malaria. In particular, Pvs25 and Pvs28 polypeptides, variants, including...
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7192933 |
Use of a baculovirus to express an exogenous gene in a mammalian cell
Disclosed is a method of expressing an exogenous gene in a mammalian cell, involving infecting the cell with a baculovirus whose genome carries an exogenous gene, and growing the cell under...
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7192917 |
Antagonists of HMG1 for treating inflammatory conditions
There is disclosed a pharmaceutical composition and method for treating sepsis, including, septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount...
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7192605 |
Nucleic acid transfer complexes
The present invention relates to compositions and methods for transferring nucleic acids into cells in vitro and in vivo. The compositions comprise a transfection reagent and one or more...
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7192579 |
Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter
The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting...
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7189705 |
Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
The present invention provides novel and surprisingly effective methods for delivering nucleic acids to cells. These methods are based upon the discovery that the presence of endosomal membrane...
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7189569 |
Modulation of cell division by an early mitotic inhibitor protein
Emi1 regulates progression through early mitosis by preventing premature APC activation. Depleting Emi1 from cycling cells strongly delays cyclin B accumulation and mitotic entry, while expression...
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7186702 |
Method of treating leishmaniasis using methyl-beta-cyclodextrin
The present invention relates to a composition useful for the treatment of leishmaniasis said composition comprising pharmaceutically effective amount of methyl-beta-cyclodextrin, optionally...
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7186699 |
Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes
The present invention provides therapeutic compositions and methods for vector-mediated delivery and in vivo expression of polynucleotides encoding anti-cancer compounds that are effective in the...
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7186698 |
Spatial and temporal control of gene expression using a heat shock protein promoter in combination with local heat
The invention provides methods for using local heat to control gene expression. The heat shock protein (hsp) gene promoter is recombined with a selected therapeutic gene and expressed in selected...
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7186697 |
Nucleic acid delivery system, methods of synthesis and use thereof
A nucleic acid delivery system is described. The delivery system contains a fusion protein having a target moiety and a nucleic acid binding moiety, and a nucleic acid sequence bound to the nucleic...
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7186556 |
Modulating transcription of genes in vascular cells
A method of modulating the transcription of one or more genes in a vascular or cardiac cell, wherein the method comprises a step of contacting the cell with a composition comprising one or more...
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RE39497 |
Storage of materials
A material or mixture of materials which is not itself storage stable is rendered storage stable by incorporation into a water-soluble or swellable glassy or rubbery composition which can then be...
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7183263 |
Linear polyethylenimine-sterol conjugates for gene delivery
Linear polyethylenimine was modified with sterols, such as cholesterol, in three different geometries: linear shaped (L), T-shaped (T), and a combined linear- and T-shaped (LT), to result in linear...
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7183262 |
Method for selective expression of therapeutic genes by hyperthermia
A method for controlling in vivo heat-inducible gene expression for provision of therapeutic polypeptide. The method includes the steps of: (a) providing a construct comprising a polynucleotide...
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7183111 |
Immunomodulatory formulations and methods for use thereof
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC)...
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7183105 |
Eubacterial minicells and their use as vectors for nucleic acid delivery and expression
Th invention provides compositions and methods for the production of achromosomal and anucleate cells useful for applications such as diagnositic and therapeutic uses, as well as research tools and...
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7183100 |
Aconitase
A bacterial protein which converts 2-methyl citrate to 2-methyl isocitrate is a previously unknown target for antibacterial agents. The protein of this activity is associated with mucoid bacteria...
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7183089 |
Method for enhancing production of isoprenoid compounds
The present invention provides methods of producing an isoprenoid or an isoprenoid precursor in a genetically modified host cell. The methods generally involve modulating the level of...
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7183054 |
Assay for identifying biological targets of polynucleotide-binding compounds
The present invention provides methods and systems for the identification of a biological target of a chemical compound, such as saframycin A, known to bind a polynucleotide. The invention also...
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7179797 |
Methods and compositions for treating prostate cancer using DNA vaccines
A DNA vaccine for the treatment of prostate cancer, comprising a plasmid vector comprising a nucleotide sequence encoding prostatic acid phosphatase (PAP) operably linked to a transcription...
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7179796 |
Antisense modulation of PTP1B expression
Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic...
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7179795 |
Nucleic acids encoding chimeric proteins comprising BMP-2 and a proteinase inhibitor
This invention relates to an agent for producing a pharmaceutical drug for postoperative use after removal of bone tumors produced from a nucleic acid by linking a known sequence for promoting bone...
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7179646 |
Gene expression using T cell factor responsive element
Disclosed are DNA elements and constructs useful for obtaining tumor-selective gene expression in tumors having a mutated β-catenin/APC pathway. In particular, the use of these constructs to...
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7179645 |
Ii-Key/antigenic epitope hybrid peptide vaccines
Disclosed is a nucleic acid molecule comprising a first expressible sequence encoding a protein of interest or polypeptide of interest which contains an MHC Class II-presented epitope. In addition,...
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