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7179487 |
Hydrogels of water soluble polymers crosslinked by protein domains
A stimuli-responsive, hybrid hydrogel wherein the bulk of the polymer is made up of relatively inexpensive water soluble polymer strands crosslinked by protein domains. The responsiveness of the...
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7176188 |
Method of lethally sensitizing human and animal cells
The present invention relates to a method, nucleic acid and amino acid sequences to sensitizing human or animal cells to be killed by chemical entities or irradiation. Particularly, the present...
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7176187 |
Fusion proteins based upon somatostatin receptors
The present invention is directed to fusion proteins that can be used to assay gene transfer and expression both in vitro and in vivo. The fusion proteins contain a reporter protein, e.g. a...
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7176186 |
Stimulation of cell-mediated immune responses by targeted particulate genetic immunization
The present invention relates to various methods of genetic immunization for the purpose of providing antigen-specific immunity in a mammalian host, including a human host. The invention is based...
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7176178 |
Nuclear targeting by means of bacterial proteins
A nuclear delivery construct comprises (i) protein H or a fragment or derivative thereof that is capable of being targeted to the nucleus of a eukaryotic cell; and associated therewith (ii) one or...
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7175840 |
Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present...
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7175658 |
Artificial vascular grafts, their construction and use
The present invention relates to artificial vascular grafts, methods for manufacturing and uses for them. The grafts are coated on their lumen with UP50. The grafts comprise an inner surface on...
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7173015 |
Inhibition of Syk kinase expression
The present invention relates, in general, to Syk kinase and, in particular, to a method of inhibiting Syk kinase expression using small interfering RNA (siRNA).
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7173014 |
HIV-specific synthetic oligonucleotides and methods of their use
Disclosed are synthetic oligonucleotides having a nucleotide sequences specifically complementary to nucleotides 324 to 345 of a conserved gag region of the HIV-1 genome, the oligonucleotide...
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7169766 |
Methods and compositions for treating hepatitis C virus
A method and composition for treating a host infected with hepatitis C comprising administering an effective hepatitis C treatment amount of a described 1′, 2′ or 3′-modified nucleoside or a...
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7169764 |
Promoter for smooth muscle cell expression
Disclosed is a smooth muscle cell specific promoter, the SM22α gene promoter as well as the murine cDNA and genomic SM22α nucleic acid sequences. Also disclosed are methods of preventing...
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7166467 |
Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The...
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7166433 |
Transductin-1 and transductin-2 and applications to hereditary deafness
The invention provides an isolated or purified nucleic acid molecule consisting essentially of the nucleotide sequence encoding transductin-2 (TDC2), related and derivative nucleic acid molecules,...
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7166302 |
Complexing agents for compositions containing inclusion complexes
The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the...
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7166298 |
Genetic immunization with cationic lipids
A method for immunization using genetic material is disclosed. Compositions for genetic immunization comprising cationic lipids and polynucleotides are also disclosed. Methods for using genetic...
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7166287 |
Viral agent
The invention relates to post-transfusional non-A non-B hepatitis viral polypeptide, DNA sequences encoding such viral polypeptide, expression vectors containing such DNA sequences, and hosts...
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7163930 |
Pharmaceutical compositions and methods relating to fucans
Compositions, methods and the like comprising fucans such as fucoidan to treat surgical adhesions, arthritis, and psoriasis.
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7163929 |
Methods and compositions for treating flaviviruses and pestiviruses
A method and composition for treating a host infected with flavivirus or pestivirus comprising administering an effective flavivirus or pestivirus treatment amount of a described 1′, 2′ or...
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7163927 |
Antisense modulation of kinesin-like 1 expression
Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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7163926 |
Adjuvant-containing vaccines
This invention provides a DNA vaccine which comprises a naked DNA incorporating and expressing in vivo a nucleotide sequence encoding an antigenic polypeptide, preferably a gene of a pathogenic...
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7163925 |
p16 expression constructs and their application in cancer therapy
A variety of genetic constructs are disclosed that will find both in vitro and in vivo use in the area of tumor biology and cancer therapy. In particular, expression constructs are provided that...
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7163806 |
Somatic cells with ablated PrP gene and methods of use
The present invention comprises a method for producing mammalian therapeutics free from prion contamination and cells for use in such methods. Such therapeutics are produced in somatic cells having...
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7163695 |
Histidine copolymer and methods for using same
The invention provides a pharmaceutical agent delivery composition comprising: (i) a transport polymer comprising a linear or branched peptide having from about 10 to about 300 amino acid residues,...
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7163677 |
Cationic polymers having degradable crosslinks
A synthetic polymer comprises a cationic recurring unit and a crosslinking unit, wherein the crosslinking unit comprises at least a first degradable unit (preferably acid-labile) and at least a...
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7160869 |
Biologically active metal-containing nucleic acids
The invention relates to polymers comprising metal-containing nucleic acid duplexes. Methods of using the metal-containing nucleic acid duplexes to provoke physiological responses in a host animal...
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7160868 |
Nr-CAM gene, nucleic acids and nucleic acid products for therapeutic and diagnostic uses for tumors
The present invention relates to the identification of a novel role of Nr-CAM in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered...
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7157439 |
HoxD3, HoxA3, and HoxB3 compositions and methods for improved wound healing
The present invention provides methods and compositions useful in localized transfer of genetic material or proteins. Moreover, the present invention provides methods and compositions for improving...
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7157438 |
Rhob as a suppressor of cancer cell growth and cell transformation
The protein RhoB and its variants as a supressor of cancer cell growth, inhibitor of malignant cell transformation, and modulator of oncogenic signaling, wherein introducing RhoB directly, or...
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7157437 |
Methods of ameliorating symptoms of herpes infection using immunomodulatory polynucleotide sequences
The invention provides new methods of preventing and/or treating herpes virus infections, particularly reducing infection, one or more symptoms and recurrence of one or more symptoms of herpes...
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7157436 |
Therapeutically useful synthetic oligonucleotides
The present invention provides a composition and method comprising a 2–20 base 3′-OH, 5′-OH synthetic oligonucleotide (sequence) selected from the group consisting of (G x T y ) n , (T y G x...
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7157435 |
Methods for modulation of the effects of aging on the primate brain
The invention provides a clinically useful protocol for delivery of recombinant nervous system growth factors into the aging mammalian brain. The invention is particularly useful in tempering and...
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7157079 |
Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
In one embodiment, this invention provides methods of treating mammalian cancer or hyperproliferative cells, said method comprising contacting said cells with a tumor suppressor protein or tumor...
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7153839 |
Method of protecting erythricytes, in particular for improvement of blood cytopenia
The present invention concerns a compound consisting of RNA, in particular RNA extracted from yeast, a pharmaceutical composition comprising such RNA and a method for the treatment of inflammatory...
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7151090 |
Methods for enhancing graft survival by modulating heme oxygenase activity
Methods are provided wherein the survival of an organ transplant is enhanced by introducing into cells of the transplant a nucleic acid molecule that modulates heme oxygenase-I activity therein....
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7151082 |
Antagonists of HMG1 for treating inflammatory conditions
There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount...
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7150970 |
Methods of inhibiting VEGF-C
The present invention provides RNA molecules (e.g., antisense, RNAi, or siRNA) specific for VEGF-C, and further provides methods of reducing expression of VEGF-C in cells (e.g., cancer cells).
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7150873 |
Coccidiosis vaccines
The present invention relates to hydrophilic Eimeria polypeptides, DNA-fragments encoding those peptides, recombinant DNA molecules comprising such DNA-fragments, live recombinant carriers...
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7148205 |
Intravascular delivery of non-viral nucleic acid
Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then...
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7148204 |
Antisense modulation of bcl-x expression
Compositions and methods are provided for modulating the expression of bcl-x. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding bcl-x are preferred....
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7148203 |
Nucleic acid transfer vector for the introduction of nucleic acid into the DNA of a cell
This invention relates to a system for introducing nucleic acid into the DNA of a cell. The system includes the use of a member of the SB family of transposases (SB) or nucleic acid encoding the...
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7148202 |
Receptor-mediated gene delivery using bacteriophage vectors
Filamentous phage particles displaying a ligand on their surface are used to deliver a therapeutic gene to a cell. The ligand is a fusion protein with a phage capsid protein, covalently conjugated...
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7148201 |
Use of human plasma hyaluronidase in cancer treatment
The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification...
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7148191 |
Antigenic composition
The invention relates to a composition comprising
a T cell epitope or a mixture of T cell epitopes a polycationic peptide and a nucleic acid based on inosin and cytosin and its use as a...
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7148014 |
Methods of inhibiting phagocytosis
The present invention relates, in general, to methods of treating diseases resulting from interactions between immune complexes and Fc receptors. In particular, the present invention relates to...
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7144870 |
Hyaluronic acid mediated adenoviral transduction
The present invention provides methods of treatment of adenoviral mediated disease, improved methods for transducing cells with adenoviral and related vectors, and improved methods of gene therapy...
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7144869 |
Nucleic acid injected into hapatic vein lumen and delivered to primate liver
Processes are described for obtaining high levels of gene expression in primates after injection of nucleic acid to the liver via the lumen of the hepatic vein. The described process results in...
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7141552 |
Use of lipid conjugates in the treatment of diseases
The invention provides a method for treating a subject suffering from an intestinal disease, including, inter alia, Crohn's disease, ulcerative colitis, immuno-inflammatory intestinal injury,...
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7141551 |
Wound and cutaneous injury healing with a nucleic acid encoding perlecan
A description of a biomolecule named Perlecan which is added internally or topically, or is expressed from exogenously added nucleic acids, as a whole or in part, to a healing wound to improve the...
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7141550 |
Intra-tumoral administration of IL-12 encoding nucleic acid molecules
Described is the use of a nucleic acid molecule encoding an IL-12 polypeptide for the preparation of a pharmaceutical composition for the treatment of a tumor, wherein the pharmaceutical...
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7141540 |
Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
Amphiphilic biocompatible cyclodextrin grafted polymers comprising a hydrophobically modified cyclodextrin moiety, a linear linker and a biocompatible hydrophilic polymer backbone, wherein said...
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