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7417033 |
Antisense oligonucleotides capable of inhibiting the formation of capillary tubes by endothelial cells
A pharmaceutical composition that blocks angiogenesis comprising as active agent at least one substance selected from the group consisting of (i) a nucleic acid molecule of a gene coding for...
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7416842 |
DNA virus microRNA
The invention relates to isolated nucleic acid molecules comprising the sequence of a DNA virus microRNA. In another embodiment, the invention relates to single stranded DNA virus microRNA...
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7414122 |
Nucleic acids encoding B7-Like molecules and uses thereof
The present invention provides B7-Like (B7-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for...
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7414035 |
hKIS composition and methods of use
Disclosed herein are novel composition and methods for altering the proliferation of a cell. Included are wild-type and mutant hKIS polypeptides along with cyclin kinase inhibitors containing...
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7414034 |
Treatment of Parkinson's disease with oligonucleotides
The present invention relates to a method of treatment of Parkinson's disease, and to the use of antisense oligonucleotides or triplex oligonucleotides introduced into targeted brain structures to...
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7414033 |
Modulation of diacylglycerol acyltransferase 1 expression
Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding...
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7414032 |
Vaccine comprising a polynucleotide encoding an antigen recognized by a CD4+ helper T-cell and a polynucleotide encoding a tumor specific or associated antigen recognized by a CD8+ CTL
The present invention relates to a DNA vaccine for developing tumor-specific immunity. Specifically, the invention relates to a DNA vaccine comprising antigens recognized by CD4 + helper T cells...
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7414020 |
Human checkpoint kinase, hCDS1, compositions and methods
The invention provides for a novel human checkpoint kinase gene, hCDS1, comprising the nucleic acid sequence of residues 66-1694 of SEQ ID NO: 1, a protein expressed from the gene, fragments and...
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7410954 |
Adenovirus serotype 30 (Ad30)
The present invention provides an adenovirus serotype 30 (Ad30) fiber amino acid sequence. The present invention also provides polynucleotides and expression vectors encoding an Ad30 fiber and...
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7410953 |
Anticancer agent
The present invention is to offer a pharmaceutical agent which is capable of suppressing the growth of cancer in cancer cells and the surrounding tissues thereof or in tissue of non-diseased part....
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7410644 |
Recombinant pox virus for immunization against tumor-associated antigens
Recombinant pox viruses capable of expressing cell-encoded, tumor-associated antigens are disclosed. The recombinant viruses are useful for evoking an immune response against the antigen.
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7408053 |
Recombinant DNA constructs for GAG polypeptides and polypeptides produced thereby
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7407944 |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods...
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7407943 |
Antisense modulation of apolipoprotein B expression
Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides,...
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7407801 |
Truncated CMV promoters and vectors containing same
The present invention relates to nucleic acid molecules comprising certain truncated forms of the human cytomegalovirus (CMV) immediate-early enhancer-promoter, either alone or operably linked to...
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7407661 |
Methods and reagents that generate a CD8 T cell immune response
New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes...
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7405292 |
Cellular genes regulated by HIV-1 infection and methods of use thereof
This invention provides cellular gene products which have anti-apoptotic activity in HIV-1 infected cells and provides agents for the inhibition of the cellular gene products.
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7405205 |
Antitumor antisense sequences directed against R1 and R2 components of ribonucleotide reductase
Compounds and methods for modulating cell proliferation, preferably inhibiting the proliferation of tumor cells are described. Compounds that may be used to modulate cell proliferation include...
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7404950 |
Induced activation in dendritic cell
The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions...
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7402574 |
Antisense composition and method for treating cancer
A method and composition for treating colorectal cancer is disclosed. The method involves administering to a subject, a therapeutically effective amount of a morpholino antisense compound (i)...
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7402573 |
Use of nanoparticles for the DNA administration to a target organ
The invention relates to the use of DNA-loaded nanoparticles for a transfection of DNA into cells in vitro or in vivo.
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7402572 |
Immunostimulatory nucleic acid molecules
Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a...
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7402571 |
Methods and pharmaceutical compositions for healing wounds
A pharmaceutical composition and method for inducing or accelerating a healing process of a skin wound are described. The pharmaceutical composition contains, as an active ingredient, a...
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7402570 |
Amplification of human MDM2 gene in human tumors
A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting...
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7402434 |
Splice choice antagonists as therapeutic agents
The invention relates to methods and reagents for influencing alternative RNA splicing in living cells. More particularly, the invention relates to novel means for influencing RNA splice choice in...
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7399753 |
Trans-splicing mediated photodynamic therapy
The present invention provides methods and compositions for conferring selective death on cells expressing a specific target precursor messenger RNA (selective target pre-mRNA). The compositions of...
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7399752 |
High affinity nucleic acid ligands to lectins
This invention discloses high-affinity oligonucleotide ligands to lectins, specifically nucleic acid ligands having the ability to bind to the lectins, wheat germ agglutinin, L-selectin, E-selectin...
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7399751 |
Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
The present invention provides a method of providing an individual with a biological factor or intermediate thereof which comprises introducing into the individual Sertoli cells genetically altered...
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7399750 |
Methods for cardiac gene transfer
Methods for the delivery of genes to improve cardiac function including the use of viral vectors, isolation of the heart from systemic circulation, and induction of hypothermia/cardiac arrest are...
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7396922 |
Regulation of hypoxia-inducible gene expression with antisense Inhibitory PAS domain protein
A pharmaceutical composition comprises the sequence of SEQ ID NO:s 3-5 or pharmaceutically equivalent sequences. Methods employing the pharmaceutical compositions include treatments to increase...
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7396824 |
2-O sulfatase nucleic acid compositions
The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode...
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7396823 |
Therapy inhalation involving antisense oligonucleotides for treating idiopathic pulmonary fibrosis
The invention provides antisense DNA oligonucleotides which are effective in inhibiting the expression of a wild type COL1A1 gene, wherein said oligonucleotides are used in inhalation therapy to...
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7396822 |
Immunogenic minicells and methods of use
The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject.
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7396821 |
Intravascular delivery of nucleic acid
Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then...
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7396536 |
Parasitic helminth cuticlin proteins and uses thereof
The present invention relates to: parasitic helminth cuticlin proteins; parasitic helminth cuticlin nucleic acid molecules, including those that encode such cuticlin proteins; antibodies raised...
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7396528 |
Corneal cells expressing active agents and methods of use thereof
The invention relates to methods of modifying cells of corneal tissue to express an active agent, to modified corneal tissue, to vectors utilised in such methods and to methods of xeno- and...
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7393950 |
Antisense oligonucleotides targeted to human CDC45
Antisense oligonucleotides that inhibit expression of human replication-initiation protein as well as methods of preventing or treating hyperproliferative conditions using said oligonucleotides are...
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7393949 |
Human immunodeficiency virus (HIV) nucleotide sequences
Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome,...
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7393524 |
Baculovirus vectors comprising a capsid polypeptide fused to a GNRH polypeptide
The invention relates to a genetically engineered baculovirus wherein said virus is engineered to target therapeutic agents to cells, typically cancer cells, for example prostate cancer cells.
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7390890 |
Inhibitors of nucleoside metabolism
The present invention provides compounds having the formula:
wherein A is CH or N; B is chosen from OH, NH 2 , NHR, H or halogen; D is chosen from OH, NH 2 , NHR, H, halogen or SCH 3 ; R is an...
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7390792 |
MicroRNA1 therapies
Delta protein expression in a cell is reduced by introducing miR-1 into the cell, and detecting a resultant reduction of Delta protein expression in the cell.
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7390791 |
Prodrugs of phosphonate nucleotide analogues
A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a)
having substituent groups as...
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7390780 |
Gene delivery mediated by liposome-DNA complex with cleavable peg surface modification
A liposome composition and method for delivery of a nucleic acid in vivo or ex vivo is described. The liposomes in the composition are comprised of (i) a cationic lipid and (ii) a lipid joined to a...
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7390482 |
Drug for auditory dysfunction
The present invention provides a pharmaceutical preparation for hearing impairment, which is suitable for gene therapy of hearing impairment, that is, a pharmaceutical preparation for hearing...
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7387271 |
Immunostimulatory combinations
The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also...
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7385038 |
Non-natural labeled amino acid and method of constructing amino acid/tRNA complex
This invention relates to: a labeled amino acid that can be introduced into a protein with the aid of a protein synthesis system; a functional protein having functions derived from a label...
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7384923 |
Liposomes
Cationic liposomes with entrapped polynucleotide in the intravesicular space are described. The liposomes include cationic components such as cationic lipids such as DOTAP. Preferably the method of...
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7384641 |
Immuno-modulating effects of chemokines in DNA vaccination
The present invention relates to a composition and method for enhancing the efficacy of a vaccine in a subject treated with the vaccine by administering to the subject an antigen in conjunction...
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7381712 |
In vivo transfection in avians
The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a...
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7381711 |
Substances for preventing and treating autoimmune diseases
A substance for preventing, delaying the onset of, or treating one or more than one autoimmune disease, the substance comprising a polynucleotide construct comprising a polynucleotide sequence...
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