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5830497 |
Medicated plaster containing basic physiologically active agents and/or salts thereof
Medicated plasters composed of a flexible support and a pressure-sensitive adhesive layer laminated thereon, in which said pressure-sensitive adhesive layer has an exposed surface with pH of 7 or...
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5830490 |
Method and device for organizing and coordinating the combined use of topical aerosols and oral medications for the treatment of disorders
A method and device for organizing, storing, instructing, and coordinating the combined use of aerosol and oral medications for the treatment of disorders including respiratory tract disorders for...
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5730975 |
Treatment of insulin resistance in obesity linked type II diabetes using antagonist to TNF-alpha function
An induction of TNF-α mRNA expression has been observed in adipose tissue from four different insulin resistant rodent models of obesity and diabetes. TNF-α protein was also elevated locally and...
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5693676 |
Nitric oxide donor composition and method for treatment of anal disorders
A pharmaceutical composition contains a nitric oxide donor and advantageously an optional corticosteroid and/or topical anesthetic. The composition is useful in a method for treating anal disorders...
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5672588 |
Purine derivatives
A compound of formula (I), or a pharmaceutically acceptable salt thereof: ##STR1## wherein X is hydrogen, amino, halogen, hydroxy, lower alkoxy or lower alkyl and R 1 is ##STR2## wherein Y is...
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5668180 |
Alkoxyaryl compounds
A compound selected from those of formula (I): ##STR1## in which A, R, Y, R 1 , R 2 and R 3 are as defined in the description, and a medicinal product containing the same useful for treating a...
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5648101 |
Drug delivery of nitric oxide
A method of delivering NO gas to a desired situs on or in the body of a sentient animal, e.g. humans, comprising combining and causing to react a soluble reducing salt, preferably ferrous sulfate,...
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5637309 |
Physiologically active substance-prolonged releasing-type pharmaceutical preparation
A prolonged releasing pharmaceutical preparation is provided carrying a physiologically active substance, particularly, calcitonin gene-related peptide (CGRP) or a maxadilan (MAX). This...
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5616325 |
Stimulator of vascular endothelial cells and use thereof
The use of extracts of Tremella fuciformis (Berk) in maintaining the permeability of microvascular walls and its effect on the microcirculatory system, especially with regard to treatment of...
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5614542 |
Thiazolidine derivatives having anti-hypertensive activity and their therapeutic use
Thiazolidine derivatives of formula (I): ##STR1## (in which: R 1 , R 2 , R 4 , R 5 are each hydrogen or alkyl; and R 3 is hydrogen, aliphatic acyl, alkoxy-carbonyl, or arylcarbonyl and...
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5603918 |
Aerosol composition of a salt of ipratropium and a salt of albuterol
The present invention is concerned with an aerosol formulation which contains an effective amount of a pharmaceutically acceptable salt of ipratropium and an effective amount of a pharmaceutically...
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5591457 |
Method of inhibiting the aggregation of blood platelets and stimulating the immune systems of a human
A method of inhibiting the aggregation of blood platelets in a human, which comprises: (a) contacting from about 0.01 ml to about 400 ml of blood with a blood platelet aggregation-inhibiting...
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5571794 |
Non-invasive novel method fo cosmetic lip augmentation
A cosmetic treatment for inducing upper and lower lip augmentation in humans, wherein an active ingredient encouraging vasodilatation, preferably an ultra highly diluted homeopathic, ultra highly...
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5565448 |
Medicament
The present invention relates to the treatment and prevention of conditions wherein protein Kinase C inhibition is indicated.
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5554610 |
Inhalational treatment of pulmonary hypertension and related conditions
A method for the treatment and/or prophylaxis of disorders associated with pulmonary hypertension and/or disorders associated with right heart failure, in mammals, such as humans, which method...
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5530001 |
Pharmaceutical use of dihydropyridine derivative
A novel pharmaceutical use of a dihydropyridine derivative of the formula (I) ##STR1## wherein R 1 , R 2 and R 3 are the same or different and each is an alkyl or the like; R 4 is a hydrogen...
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5527533 |
Method of retarding and ameliorating central nervous system and eye damage
A method of retarding and ameliorating eye diseases and injuries is disclosed. The method comprises administering astaxanthin in a therapeutically-effective amount to prevent, retard or treat eye...
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5500434 |
Combination of angiotensin-converting enzyme inhibitors with calcium antagonists as well as their use in drugs
The invention relates to combinations of angiotensin-converting enzyme inhibitors with calcium antagonists, processes for their preparation and their use as medicaments.
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5492904 |
Composition of angiotensin-II receptor antagonists and calcium channel blockers
Novel pharmaceutical compositions containing a combination of an angiotensin-II antagonist and a calcium channel blocker such as 2-butyl-4...
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5461039 |
Method for treating hypertension employing a cholesterol lowering drug
A method is provided for treating hypertension in normotensive patients having insulin resistance by administering a cholesterol lowering drug, such as pravastatin, alone or in combination with an...
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5445812 |
Angiographic adjuvant
An angiographic adjuvant comprising a fat emulsion containing a compound having prostaglandin E1 activities, and an angiographic method using the adjuvant.
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5441947 |
Methods of inhibiting vascular restenosis
Wortmannin and certain of its analogs are inhibitors of restinosis.
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5435998 |
Treatment of low-tension glaucoma by topical administration of calcium channel blocking agents
Low-tension glaucoma is treated by topical administration to the eye of an amount of a calcium channel blocking agent effective to increase blood flow to the optic nerve head. Calcium channel...
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5433957 |
Vasodilating agent
A vasodilating agent and a hair growth promoting agent comprising an extract of hypericum erectum thunb as an effective component are disclosed. The hypericum erectum thunb extract is prepared from...
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5431907 |
Treatment of vascular disorders of the posterior segment of the eye by topical administration of calcium channel blocking agents
Ischemic disorders of the retina and associated tissues of the posterior segment of the eye are treated by topical administration to the eye of an amount of a calcium channel blocking agent...
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5401503 |
Hair growth stimulant
A composition for use in hair growth stimulant and blood circulation stimulant, which contains as active ingredient an extract fraction containing non-aconitine type alkaloidal components which is...
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5389675 |
Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents
Mixed ligand metal complexes of nitric oxide-nucleophile adducts, useful as cardiovascular agents of the formula KA, wherein A is [(M) x x ' (L) y (R 1 R 2 N-N 2 O 2 ) x ], and K is a...
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5385914 |
Cardiotonic carbostyril agents for treating heart ailments
Method for prophylaxis and treatment of heart diseases using a carbostyril derivative-of formula: ##STR1## wherein R 1 is H or CN, and R 2 and R 3 are each H, alkyl optionally substituted by OH,...
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5384123 |
Topical composition and method for rejuvenating skin
The invention provides a topical composition for rejuvenating skin texture, comprising a first topically applicable component for stimulating the flow of blood in the arteries leading to, and...
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5376672 |
Method for treating tension type headaches or headaches associated with drugs or their withdrawal
The present invention provides a new medical use for 3-[2-(dimethylamino)-ethyl]-N-methyl-1H-indole-5-methanesulp
honamide and physiologically acceptable salts and solvates thereof in the treatment...
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5366997 |
Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs
There are disclosed cardiovascularly active compounds possessing antihypertensive properties, and pharmaceutical compositions containing these agents and a method of treating cardiovascular...
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5362757 |
Composition and method containing optically pure (S) metoprolol
Optically pure (S) metoprolol, which is substantially free of the (R) enantiomer, is a potent beta-blocker for treating myocardial infarction and for relieving the symptoms of angina pectoris,...
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5334392 |
Matrix tablet permitting the sustained release of indapamide after oral administration
The invention relates to a matrix tablet for the sustained release of indapamide which ensures a continuous and uniform release of the active principle after oral administration.
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5294346 |
Composite microporous membranes
The composite membrane is disclosed having a microporous support which is coated with a polymer composition and a contact adhesive layer applied to said polymer. A process for making and a process...
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5286739 |
Parenteral formulations for the inhibition of systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor
An anti-hypotensive formulation comprising an essentially arginine-free or low arginine (less than about 0.1%, most preferably, about 0.01%) containing mixture of amino acids is provided. The...
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5281421 |
Gemfibrozil formulations
Improved oral formulations are prepared by admixing gemfibrozil with from 1 to 4%, by weight, of a pharmaceutically acceptable surfactant having an HLB value of from about 10 to about 50.
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5272153 |
Method of inhibiting the activity of leukocyte derived cytokines
A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, and the activity of other leukocyte derived cytokines is comprised of 7-(oxoalkyl)...
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5268182 |
Sustained-release drug dosage units of terazosin
A sustained-release coating composition is described that contains an ethylcellulose and/or a methacrylic methylester together with a plasticizer and a detackifying agent. Sized drug granules are...
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5268164 |
Increasing blood-brain barrier permeability with permeabilizer peptides
Polypeptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. These receptor mediated...
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5240930 |
Pharmaceutical compositions for treatment of depression and low blood pressure
A pharmaceutical composition which comprises a mixture of an alpha-2 adrenoceptor antagonist, preferably idazoxan, or a pharmaceutically acceptable salt thereof, and either a catecholamine...
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5225189 |
Minoxidil gel
The present invention provides a novel pharmaceutically acceptable gel containing minoxidil for topical application.
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5212204 |
Antihypertensive compositions and use thereof
This invention concerns antihypertensive compositions and a method of lowering blood pressure in mammals. The active component of the compositions is a compound of the formula: ##STR1## wherein J...
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5206264 |
Use of disulfiram to prevent cardiovascular damage
A method is disclosed for reducing cardiovascular damage caused by hypoxic or ischemic events such as heart attack and cardiac arrest. This method involves the administration of disulfiram, or a...
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5196430 |
Method of inhibiting the activity of leukocyte derived cytokines
A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, and the activity of other leukocyte derived cytokines is comprised of 7-(oxoalkyl)...
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5196429 |
Method of inhibiting the activity of leukocyte derived cytokines
A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, and the activity of other leukocyte derived cytokines is comprised of 7-(oxoalkyl)...
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5187195 |
Anthraquinone derivatives and preparation thereof
Anthraquinone compounds of the formula: ##STR1## wherein: R 1 is hydrogen, hydroxy or acyloxy, R 2 is hydrogen or acyl, R 3 is acyl, R 4 is hydrogen or acyl, R 5 is hydrogen or...
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5175179 |
Method for treating hypertension
A method of using certain thiazolidine-2,4-diones in the treatment of hypertension.
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5169840 |
Diequatorially bound β-1, 4 polyuronates and use of same for cytokine stimulation
The present invention is directed to a material and method for the stimulation of the production of cytokines. Several polysaccharides, including polymers of different size of ♁1-4 linked...
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5169836 |
Inhibitors of platelet binding
Peptides comprising the tripeptide sequence of arginine-tyrosine-aspartic acid, linked from amino- to carboxy-terminus, are inhibitors of fibrinogen binding, platelet aggregation, glycoprotein...
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5166211 |
Method of using 1,4-disubstituted piperidinyl compounds in the treatment of coronary vasospasons and variant angina
The present invention pertains to a new class of compounds which can be characterized as 1,4-disubstituted piperidinyl compounds useful as antiarrhythmics, analgesics, and serotonin 5HT 2 ...
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