Matches 151 - 200 out of 652 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 >
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4595675 Bicyclic α-iminocarboxylic acid compounds having hypotensive activity  
What are disclosed are indole, quinoline and isoquinoline compounds of the formula ##STR1## in which n denotes 0 or 1, m denotes 1 or 2, but (n+m)≤2, A together with the bridgehead carbon atoms...
4584315 Method of treating ischemic states  
The present invention relates to novel methods of use for known pharmacological anti-allergenic agents including disodiumchromoglycate (DSCG) and related compounds thereof, including generally bis...
4578387 Inotropic agents  
This invention provides for certain phenyl-substituted imidazo compounds, their pharmaceutical formulations, and their use as positive inotropic agents and vasodilators.
4571403 Antianginal medicated compound  
The anginal medicated compound according to the present invention comprises the active principle 2,4,6,8-tetramethyl-2,4,6,8-tetraazobicyclo-/3,3,0/-octanedi one-3,7 of the formula: ##STR1## in...
4568689 Pharmaceutical preparation for the treatment of hypertensive disease and myocardial infarction  
A novel pharmaceutical preparation for the treatment of hypertensive disease and myocardial infarction, which comprises as an active ingredient, (1,1-dimethyl-3-oxopyrazolidin-1-io-4-yl)acetate of...
4542159 Cycloaliphatic ketoamines  
There are prepared compounds of the formula: ##STR1## wherein X is the group >CO or >CH(OH), Y is the group ##STR2## R 2 is hydrogen or C 1 to C 6 alkyl, R 3 is hydrogen or a hydroxy...
4533732 3-Propionylsalicylic acid derivatives and process for the preparation of the same  
This invention relates to derivatives of 3-propionylsalicylic acid represented by the formula (1) ##STR1## wherein R represents a hydrogen atom, a lower alkyl group or a group ##STR2## (wherein R 1...
4532135 Renoprotective treatments employing vasodilator compounds  
A treatment method and substances have been found to reduce the risk of incurring renal damage or failure. Vasodilators useful for the treatment of hypertension have been found to lower cholesterol...
4529733 Antihypertensive 3-furoyl-1,4-dihydropyridines  
Novel 1,4-dihydropyridine derivatives have the following general Formula: ##STR1## and are calcium antagonists, useful for treating cardiovascular diseases.
4529604 N,N-Di-(n-Propyl)dopamine derivatives  
N,N-Di-(n-propyl)dopamine derivatives having peripheral dopamine receptor agonist activity prepared by synthetic routes known for phenethylamines. The renal vasodilator effect of...
4526999 Lipoxygenase inhibitors  
Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit lipoxygenase, thus preventing the metabolism...
4521430 1,5-Benzothiazepin-4-one, their pharmaceutical compositoins, and methods of use  
A compound of the formula: ##STR1## wherein R 1 and R 2 are each lower alkyl, R 3 is hydrogen, lower alkyl or hydroxy-lower alkyl, R 4 is hydrogen, halogen, lower alkyl, lower alkoxy, lower...
4510307 6-Quinazolinesulfonyl derivatives and process for preparation thereof  
A 6-quinazolinesulfonyl derivative of Formula (I): ##STR1## wherein R 1 is a hydrogen atom or a C 1 -12 alkyl group: R 2 is a hydrogen atom, a C 1 -12 alkyl group, a C 4 -10 cycloalkyl group,...
4510149 N-Imidazolyl derivatives containing naphthalene or indene nucleus  
Compounds of the formula (I) ##STR1## wherein the symbol represents a single or a double bond; Z completes a single bond or is a --CH 2 -- group; each of R 1 , R 2 , R 3 and R 4 , which may...
4496544 Atrial Peptides  
Novel atrial peptides having useful natriuretic activity are disclosed with the following amino acid sequence: R 1 -cys-phe-gly-gly-arg-ile-asp-arg-ile-gly-ala-gln-ser-gly-leu -gly-cys-asn-R 2...
4495352 Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols  
1-Aryloxy-3-[(3-indolyl)-tert.-butyl]amino-2-propanols having a heterocyclic aryl-attached substituent or aryl-fused heterocyclic ring are antihypertensive agents having vasodilator and adrenergic...
4495192 1-Substituted 1,4-dihydropyridines  
A vasodilating or anti-hypertensive composition comprises a pharmaceutical carrier and an effective amount of a 1,4-dihydropyridine compound as an active ingredient. The 1,4-dihydropyridine...
4489078 Diazaheterocyclopurines used as anti-broncho spasmatics and vasodilators  
Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase...
4482485 Method of preparation of human urine origin colony-stimulating factor and kallikrein  
Human urine-origin colony-stimulating factor and kallikrein are separated in pure form, respectively, from an aqueous solution thereof, such as a urinary protein-concentrated solution by subjecting...
4478838 1-(3,4,5-Trimethoxycinnamoyl)-4-alkylaminocarbonylethyl piperazines  
1-(3,4,5-Trimethoxycinnamoyl)-4-aminocarbonylethyl-substitut ed piperazine derivatives represented by general formula (I): ##STR1## wherein R is a straight- or branched-chain alkyl group having 1...
4473501 Dihydro azino isoquinolines  
The invention provides novel 1,5-substituted isoquinoline derivatives of formula I which are useful in the treatment of hypertension.
4461896 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids  
A series of 1-[acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxy lic acids and salts thereof are useful as Angiotensin I converting enzyme inhibitors.
4450175 Method and compositions for treating acne  
Acne is treated by the topical application of a vasodilating agent to loci of acne papules.
4443453 Quinoline derivatives, pharmaceutical compositions containing such compounds, and methods for treating cardiovascular conditions with them  
The invention is concerned with novel quinoline derivatives of the formula ##STR1## or a salt thereof, in which A--B is --CH 2 --CH 2 --, --CHOH--CH 2 --, --CH 2 --CHOH--, --CH 2 --C(O)--,...
4442108 Hydrogenated isoquinolines and peripheral vascular disease treating compositions thereof  
1-(3,4-Dialkoxybenzyl)-6,7-dialkoxyl-1,2,3,4-tetrahydro- and 3,4-dihydroisoquinolines wherein the alkoxy groups in the benzyl ring are different from those in the isoquinoline nucleus and one...
4442107 Quinoline derivatives, pharmaceutical compositions containing such compounds, and methods for treating cardiovascular conditions with them  
The invention is concerned with quinoline derivatives having cardiovascular activities of the formula ##STR1## or a salt thereof, in which A--B is --CH 2 --CH 2 --, --CHOH--CH 2 , --CH 2 ...
4442106 Quinoline derivatives, pharmaceutical compositions containing such compounds, and methods of treating cardiovascular conditions with them  
The invention is concerned with novel quinoline derivatives having cardiovascular activities of formula 1 ##STR1## in which A--B is --CH 2 --CH 2 --, --CHOH--CH 2 , --CH 2 --CHOH--, --C(O)--CH 2...
4440774 3-Amino-2-hydroxypropoxyaryl imidazole derivatives  
Novel substituted imidazoles of the formula ##STR1## and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes...
4439442 Naftidrofuryl citrate and therapeutic applications  
The object of the invention is a new naftidrofuryl salt, naftidrofuryl citrate, which is therapeutically useful because it promotes metabolism and circulatory properties and because of its...
4438116 Quinoxalinyloxy-amino-propanol compounds with blood pressure lowering and β-blocking properties, their use and pharmaceutical compositions containing them  
An aminopropanol compound of the formula ##STR1## wherein R 1 and R 2 are individually selected from hydrogen and lower alkyl; or R 1 and R 2 together represent an alkylene radical; R 3 ...
4434162 Phosphonic acid ester, pharmaceutical compositions containing the same and method of using the same  
A phosphonic acid ester of the formula ##STR1## exhibits calcium-antagonistic, coronary vasodilating and hypotensive activities. Pharmaceutical compositions containing the same are useful for the...
4430342 N-Acyl-3-[4-(benzoylalkyl)piperazin-1-yl]-sydnonimine compound, process for prodction thereof, and use thereof  
An N-acyl-3-[4-(benzoylalkyl)piperazin-1-yl]-sydnonimine compound represented by the following formula ##STR1## wherein R 1 represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms,...
4430333 Dihydropyridine anti-ischaemic and antihypertensive agents  
Dihydropyridine anti-ischaemic and antihypertensive agents of the formula: ##STR1## where Y is --(CH 2 ) 2 -- or --(CH 2 ) 3 --; R is aryl or heteroaryl; R 1 and R 2 are each...
4426394 Diphenylalkanoether and diphenylalkanone oximeether derivatives  
Diphenylalkanoether and diphenylalkanone oximeether derivatives of the formula: ##STR1## wherein R 1 and R 2 are each independently an aryl group optionally substituted with 1 to 3 substituents...
4426383 Theophylline and theobromine derivatives  
A novel compound has the following formula: ##STR1## in which R 1 and R 2 are methyl or a group having the formula: ##STR2## provided that one of R 1 and R 2 is methyl and the other is said...
4423045 Thiadizines  
Novel heterocyclic compounds of the formula: ##STR1## wherein either X is --CR 1 R 2 -- and Y is oxygen, sulphur or --NR 3 , wherein R 1 , R 2 and R 3 , which may be the same or different, each...
4421754 Syndonimine derivatives, process for production thereof, and use thereof  
A 3-[4-(benzoylalkyl)piperazin-1-yl]sydnonimine compound represented by the following formula ##STR1## wherein R represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and n...
4414213 Dihydropyridyl cyclic imidate esters and their pharmaceutical use  
A series of 1,4-dihydropyrid-5-yl cyclic imidate esters have been prepared possessing the general formula ##STR1## wherein R and R 1 are independently selected from hydrogen, lower alkyl or...
4391815 Cyanobenzano[b]pyrans  
2,2-Dimethyl-3,4-dihydro-2H-benzo[b]pyran-3-ols bearing an amino group in the 4-position and a cyano group in the benzo ring, their salts, esters and ethers, demonstrate excellent vasodilatory...
4382936 Cerebral vasodilator eburnane derivatives  
A compound of the formula: ##STR1## wherein R 1 is a C 1 -C 6 alkyl group and R is a hydrogen atom or a C 1 -C 6 alkyl group, and their salts, which are useful as cerebral vasodilator; and a...
4380644 2-Oxoimidazolidine derivatives  
A 2-oxoimidazolidine derivative of the formula: ##STR1## wherein R 1 is lower alkyl or phenyl-lower alkyl and R 2 is lower alkyl or phenyl, and a process for preparation thereof are disclosed....
4379792 Anti-inflammatory composition  
A pharmaceutical composition containing an interphenylene 9-thia-11-oxo-12-aza prostanoic acid type renal vasodilator and a non-steroidal anti-inflammatory agent and its use are disclosed.
4366157 Novel polycyclic indole derivatives  
A compound of the formula, ##STR1## wherein R 1 is C 1 -C 6 alkyl group and R 2 is aryl group, which is a medicine useful to treat cerebral arteriosclerosis, senile mental indolence and...
4366156 Antiallergic methods using diazaheterocyclopurines  
Imidazopyrimidinones and other diazaheterocyclopyrimidinones having an additional fused imidazole or triazole ring have utility as bronchodilators, mediator release inhibitors, phosphodiesterase...
4365064 1,2,4-Oxadiazolin-5-one derivatives, process for their preparation and pharmaceutical compositions containing them  
The invention concerns new compounds of the formula (I) ##STR1## wherein R 1 is hydrogen, phenyl or phenyl substituted with at least one alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1...
4365063 Antihypertensive agents  
1,4,5,6,7,8-Hexahydro-2-alkyl-4-pentafluorophenyl-5-oxo-1,7- naphthyridine-3 -carboxylic acid esters and pharmaceutically acceptable salts thereof are useful antihypertensive agents.
4359420 Thieno-1,4-diazepin-5-ones and benzo-1,4-diazepin-5-ones  
Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as α and β is selected from the group consisting of ##STR2## the dotted line represents...
4352793 Pharmaceutical composition comprising bencyclane fumarate and cyclodextrin  
A composition comprising as the pharmaceutically active ingredient bencyclane fumarate and cyclodextrin. As compared with prior bencyclane fumarate preparations, this composition can greatly...
4350696 Imidazole derivatives, process for their preparation and pharmaceutical compositions thereof  
Compounds of the general formula: ##STR1## wherein X is a group of the formula: ##STR2## m is 2 or 3; n is an integer of from 1 to 4; and R is a 5-membered heterocyclic group containing as...
4348395 1,4-Dihydropyridazine compounds  
The invention includes, as novel compounds, 1,4-dihydropyridazines and methods for their preparation. Also included are compositions containing said compounds and methods for the use of said...
Matches 151 - 200 out of 652 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 >