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7615614 |
Antigen constructs useful in the detection and differentiation of antibodies to HIV
Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env...
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7615613 |
Antigen constructs useful in the detection and differentiation of antibodies to HIV
Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env...
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7615533 |
TPO peptide compounds for treatment of anemia
Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed.
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7615530 |
Immunogenic compositions and methods of use
Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A...
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7615527 |
Peptides which modulate blood coagulation and methods of use thereof
Peptide fragments that modulate thrombosis and methods of use thereof are provided. Also provided are synthetic bioactive anti-coagulation peptides, compositions comprising such peptides and...
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7612190 |
Method for targeting a polypeptide onto cellular surface
The present invention relates to a polypeptide having an activity for targeting a heterogeneous polypeptide to a surface of cytoplasmic membrane, a nucleic acid encoding the polypeptide, a...
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7612162 |
Peptide analogs capable of enhancing stimulation of a glioma-specific CTL response
The invention provides a peptide derived from the interleukin-13 receptor α2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for...
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7612043 |
Method of reducing or inhibiting ObR signaling using a leptin antagonist consisting of SEQ id No: 2
Disclosed herein are peptides comprising a leptin sequence and methods for their use in preventing ObR signaling in a leptin-responsive cell. A leptin peptide of the present invention binds to but...
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7611720 |
Tuberculosis vaccines including recombinant BCG strains expressing alanine dehydrogenase, serine dehydratase and/or glutamine synthetase
The invention relates to a live recombinant Mycobacterium bovis -BCG strain comprising a nucleic acid capable of expression, the nucleic acid encoding at least one protein or polypeptide that...
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7611713 |
Inducing cellular immune responses to hepatitis B virus using peptide compositions
This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application...
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7608696 |
IBC-1 (invasive breast cancer-1), a putative oncogene amplified in breast cancer
This invention encompasses antibodies specific for IBC-1 (Invasive Breast Cancer-1), methods for diagnosis and prognosis of metastatic breast cancer and degenerative neural conditions, methods of...
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7608691 |
Antibodies against IL-16 antagonist peptides
The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The...
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7608686 |
Human tumor necrosis factor receptor
Tumor necrosis factors and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human tumor necrosis factor receptor designated as...
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7608685 |
Tumor antigen based on products of the tumor suppressor gene WT1
A tumor antigen that comprises, as an active ingredient, a product of the Wilms' tumor suppressor gene WT1 or a peptide composed of 7-30 contiguous amino acids containing an anchor amino acid for...
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7608684 |
Soluble CD14 antigen
There are provided a soluble CD14 antigen which is a novel in vivo protein useful as a marker for diagnosing sepsis and has the following characteristic features 1) to 3):
1) a molecular...
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7608683 |
Stress proteins and peptides and methods of use thereof
Provided are HLA pan DR-binding peptides and methods of using such peptides to modulate, block, or inhibit immune responses to effect treatment of immune-mediated diseases and conditions, such as...
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7608682 |
Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrates
The present invention relates to methods, compositions, compounds and kits for detecting, measuring and modulating protein ubiquitylation via the N-end rule pathway and for identifying novel...
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7608681 |
Methods and compositions for prolonging elimination half-times of bioactive compounds
Peptide ligands having affinity for IgG or for serum albumin are disclosed. Also disclosed are hybrid molecules comprising a peptide ligand domain and an active domain. The active domain may...
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7608582 |
Delivery vehicle comprising a modified MscL protein channel
The invention relates to the field of drug delivery, in particular, to compounds and methods for the chemical modification of a proteinaceous channel to be used in pharmaceutical delivery vehicles...
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7608581 |
Biofunctional, antimicrobial coatings for medical devices
The present invention provides compositions and methods for an improved coating for medical devices. Provided is an interfacial biomaterial or biofunctional coating composition comprising at least...
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7608577 |
Peptidyl ketones as inhibitors of DPIV
The present invention relates to compounds of the general formula 1
and pharmaceutically acceptable salts thereof, to the use of the compounds for the treatment of impaired glucose tolerance,...
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7608405 |
Method of selectively assaying adiponectin multimers
Methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of...
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7608404 |
Disease determination method, data generation method for disease determination and data generation system for disease determination
Supernatant of the urinary sample (SP 1 ) was mixed with an acid or alkali and heated (SP 2 ) and the sample for fluorescence assay was prepared after adjusting its acidity to alkaline (SP 3 )....
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7608277 |
Tuberculosis nucleic acids, polypeptides and immunogenic compositions
The present invention provides transcriptionally active Mtb polynucleotides, recombinant Mtb peptides and polypeptides, and immunogenic Mtb antigens. Immunogenic compositions are also provided that...
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7608256 |
Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response
Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I...
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7605248 |
Recombinant constructs of Borrelia burgdorferi
Novel chimeric nucleic acids, encoding chimeric Borrelia proteins comprising OspC or an antigenic fragment thereof and OspA or an antigenic fragment thereof, are disclosed. Chimeric proteins...
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7605121 |
Oligopeptide lyophilisate, their preparation and use
A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the...
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7604954 |
Method for evaluating kidney function in a feline
Methods for ( 1 ) evaluating feline kidney function by determining ghrelin level in feline tissue or biofluid and correlating the ghrelin level directly to kidney function and ( 2 ) diagnosing...
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7604810 |
Conserved Neisserial antigens
To ensure maximum cross-strain recognition and reactivity, regions of proteins that are conserved between different Neisserial species, serogroups and strains can be used. The invention provides...
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7601810 |
Insecticidal plant cyclotide with activity against homopteran insects
The present invention relates to isolated nucleic acids encoding plant cyclotides. The invention also relates to the construction of a chimeric gene encoding all or a portion of the plant...
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7601807 |
Protease, DNA encoding the same, and method for manufacturing protease
A protease having the following characteristics:
(i) a molecular weight of 21,000±1,000 (by SDS-PAGE) and (ii) specific protease activity cutting the Gly-Phe site of a peptide or protein...
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7601800 |
Compositions and methods for monitoring breast cancer treatment
The present invention provides compositions and processes for preparing the same wherein the compositions are useful for monitoring breast cancer treatment.
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7601799 |
Methods and means to promote gut absorption
The present invention relates to epidermal growth factor (EGF) producing lactic acid bacteria and their use to increase intestinal villi height and to promote gut absorption. In particular, the...
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7601691 |
Anti-obesity agents
The present invention relates to a compound comprising a PYY peptide or a functional derivative thereof, which is coupled to a reactive group. Such a reactive group is capable of reacting on a...
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7601685 |
Growth factor modified protein matrices for tissue engineering
Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are...
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7601518 |
Secretion of neublastin
The present invention concerns improved methods and compositions for producing a Neublastin polypeptide as well as local delivery of Neublastin to specific regions of the nervous system including...
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7601491 |
Pretreatment method for extraction of nucleic acid from biological samples and kits therefor
The present invention relates to methods for pretreating biological samples for extraction of nucleic acid therefrom The present invention employs a combination of at least one protein denaturant...
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7601358 |
Mycobacterium tuberculosis protein composition
Mycobacterium tuberculosis proteins and protein compositions that are components of a desaturase complex are provided. The Mycobacterium tuberculosis desaturase complex may include a desaturase...
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7601357 |
Targeting of long chain triacylglycerol hydrolase gene for tuberculosis treatment
Disclosed herein are novel methods for screening for compounds useful in treating or preventing tuberculosis. In exemplary embodiments, screening methods are based on the implementation or...
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7601350 |
Antibodies that bind M. tuberculosis polypeptides
Purified antibodies that bind to M. tuberculosis ERP protein are disclosed. In one embodiment, a purified antibody, which binds specifically with a polypeptide comprising SEQ ID NO: 39 or SEQ ID...
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7598356 |
Method for purifying a protein of the cystine-knot superfamily
The present invention relates to a two-step method for isolating proteins from the cystine-knot superfamily based on dye ligand affinity chromatography and reversed-phase chromatography....
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7598346 |
Antifungal polypeptides
The invention relates to compositions including amino acid sequences isolated from fungal fermentation broths and methods for protecting a plant from a pathogen, particularly a fungal pathogen.
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7598342 |
Alpha-fetoprotein peptides and uses thereof
The invention relates to compounds that include peptide and peptidomimetics that inhibit estrogen receptor dependent cell proliferation. The compounds of the invention are useful for treating cell...
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7598341 |
Molecules that selectively home to vasculature of premalignant or malignant lesions of the pancreas and other organs
The invention provides a conjugate that includes a therapeutic moiety linked to a peptide or peptidomimetic that selectively homes to vasculature of premalignant pancreas. The peptide or...
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7598340 |
Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses
A hybridoma (termed “UIC2 hybridoma”, ATCC Accession No. HB11027) producing monoclonal antibodies (termed “UIC2 mAb”) directed against an extracellular domain of a cell surface...
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7598224 |
Dual chain synthetic heparin-binding growth factor analogs
The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties...
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7598041 |
HIV-1 VPR interactions with mitochondrial apoptosis inducing factor and methods of using the same
Assays to identify Vpr/AIF interaction and translocation inhibitors are disclosed.
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7597896 |
Composition comprising a protein encoded by a modified ERP gene of Mycobacterium
The invention concerns Mycobacterium strains whereof the erp gene is modified and a vaccine composition containing same. The modification of the erp gene decreases the virulence and the...
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7597895 |
Signal peptides, nucleic acid molecules and methods for treatment of caries
Compounds that competitively inhibit binding of CSP to S. mutans histidine kinase are provided. The compounds are preferably a peptide or an antibody, and are preferably a derivative of [SEQ ID...
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7595383 |
Secreted proteins of Mycobacterium tuberculosis and their use as vaccines and diagnostic reagents
The invention provides mycobacterium tuberculosis polypeptides and genes encoding them for use in diagnostic and prophylactic methodologies.
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