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<title>freepatentsonline.com: Chemistry: molecular biology and microbiology</title>
<link>http://www.freepatentsonline.com/result.html?query_txt=ccl/435%20and%20isd/11/10/2009&amp;uspat=on</link>
<description>USPTO Class 435 Chemistry: molecular biology and microbiology</description>
<language>en-us</language>
<lastBuildDate>Tue, 10 Nov 2009 08:53:11 EST</lastBuildDate>

<item>
<title><![CDATA[Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions]]></title>
<link>http://www.freepatentsonline.com/7615374.html</link>
<description><![CDATA[Methods for obtaining multipotent mesenchymal stem cells under serum-free conditions and methods for identifying multipotent mesenchymal progenitor cells are disclosed.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Electronic detection of interaction and detection of interaction based on the interruption of flow]]></title>
<link>http://www.freepatentsonline.com/7615340.html</link>
<description><![CDATA[Porous members can be positioned so as to partially or fully span channels in microfluidic systems. The porous members can be assembled and/or disassembled in situ. The porous members can be made such that pores are separated by connections including but a single molecule at one location, allowing for a high level of open area in a very small pore size member. The porous member can be made up of colloid particles interconnected with molecular species. These can be used to detect analytes qualitatively and/or quantitatively, or to selectively bind and/or release agents on command for a variety of purposes including first blocking, then opening a channel, concentrating analyte over time followed by release of analyte and detection downstream, etc. Porous members can define valves in multiple-channel systems and, with controlled binding and release of agents at the porous members, these valves can be opened and closed and fluid flow controlled in a multi-channel system. Fluidic systems of the invention can include multiple sensing locations at which different analytes are determined. Systems of the invention provide flexibility for overall microchemical analysis, sequentially, of a variety of agents.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Process for producing extract for cell-free protein synthesis and cell extract produced thereby]]></title>
<link>http://www.freepatentsonline.com/7615344.html</link>
<description><![CDATA[It is intended to provide a process for producing an extract for cell-free protein synthesis whereby the productivity of a protein and the production efficiency can be improved. Cells are cultured under suppressed growth conditions. In the stationary phase of the culture, the cells are collected and then disrupted. The above-described cells are preferably bacterial cells, in particular,  Escherichia coli  cells. In the suppressed growth conditions as described above, the culture temperature is preferably from 20 to 32° C., more preferably 26° C. or higher and lower than 30° C.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Melanoma gene signature]]></title>
<link>http://www.freepatentsonline.com/7615349.html</link>
<description><![CDATA[Methods and compositions for evaluating gene expression in melanoma samples are provided herein.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Two stage nucleic acid amplification using an amplification oligomer]]></title>
<link>http://www.freepatentsonline.com/7615351.html</link>
<description><![CDATA[This invention provides methods, compositions and systems to detect a nucleic acid of interest in a two-stage amplification. The two-stage amplification begins with a first non-enzymatic accumulation of an amplification oligomer that is the target substrate for a second nucleic acid amplification or assay. Two or more amplification oligomers can be used to allow multiplexed amplifications of two or more nucleic acids of interest with deconvolution based on unique detection signals or unique signal locations.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Toxicity screening methods]]></title>
<link>http://www.freepatentsonline.com/7615361.html</link>
<description><![CDATA[The present invention provides methods of determining a level of toxicity of a given compound based on in vitro assays. The present invention provides particular methods of determining organ-specific toxicity and species-specific toxicity of a given compound based on in vitro assays. In addition, the present invention provides methods of determining a level of toxicity in normal tissue for an anti-tumor compound. The methods include providing at least one cell type and culturing the cell type in the presence of at least one concentration of the chemical compound, measuring at least one indicator of cell health at the at least one concentration of compound for the at least one cell type, and performing a concentration response analysis, from which a toxic concentration can be determined.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Isolated xylanase gene with mutations and site-specific mutagenesis method thereof]]></title>
<link>http://www.freepatentsonline.com/7615362.html</link>
<description><![CDATA[A mutated xylanase gene with a broad pH range of reaction includes a forty-first amino acid or a twenty-first amino acid generated from transforming asparagine to aspartic acid so as to form the mutated xylanase gene. A site-specific mutagenesis method includes the step of: mutating the forty-first amino acid or the twenty-first amino acid of the xylanase gene by transforming asparagine to aspartic acid so as to form the mutated xylanase gene.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Rapid and efficient capture of DNA from sample without using cell lysing reagent]]></title>
<link>http://www.freepatentsonline.com/7615346.html</link>
<description><![CDATA[Nucleic acids can be made available for amplification or other treatment after admixture of a sample with specific weakly basic polymers to form a precipitate with the nucleic acids at acidic pH. After removing non-precipitated materials, the pH is then made basic, thereby releasing the nucleic acids from the polymer. This method for preparing specimen samples is simple and quite rapid, and the released nucleic acids can be further treated in hybridization assays or amplification procedures. No surfactant or other cell lysing reagents are employed. The weakly basic polymers are water-soluble and cationic at acidic pH, but neutral in charge at basic pH.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Peripheral-type benzodiazepine receptor expression level as an index of organ damage and regeneration]]></title>
<link>http://www.freepatentsonline.com/7615355.html</link>
<description><![CDATA[The present invention relates to methods, reagents, and kits for assessing organ damage, such as damage due to ischemia reperfusion injury, in the course of a transplantation therapy and/or for assessing organ regeneration following transplantation therapy. The invention provides a method for determining an index of organ health in the course of transplantation therapy comprising measuring the expression level of peripheral-type benzodiazepine receptor (PBR) in the organ. Measuring the expression level of PBR is also useful for assessing the progress of organ regeneration in the course of transplantation therapy by comparing the index of organ health. The expression level of PBR may be used as a predictor of the outcome of transplantation therapy.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Method and apparatus for treating a biological sample with a liquid reagent]]></title>
<link>http://www.freepatentsonline.com/7615371.html</link>
<description><![CDATA[A method and apparatus for treating a biological sample with a liquid reagent, comprising first and second substrates having facing surfaces defining a space therebetween in which the biological sample may be treated with the liquid reagent, wherein the first substrate comprises a relatively rigid fluid impermeable element while the second substrate comprises a relatively flexible liquid impermeable element.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Arrays formed of encoded beads having oligonucleotides attached]]></title>
<link>http://www.freepatentsonline.com/7615345.html</link>
<description><![CDATA[A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Electrophoretic separation of compounds]]></title>
<link>http://www.freepatentsonline.com/7615354.html</link>
<description><![CDATA[A device, method and kit for the electrophoretic separation and purification of charged and neutral compounds in an analyte solution. The device comprises a chamber ( 1 ), at least one wall of which is composed of a chemical buffering system ( 4 ). A potential difference is applied across the buffering system, resulting in the charged and neutral compounds being differentially separated by extraction of the charged compounds into the buffering system. The device also comprises means for collecting the separated compounds, preferably in ampholyte-free or buffer-free solution and optionally means for recycling the separated fractions.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Ion channel assay methods]]></title>
<link>http://www.freepatentsonline.com/7615356.html</link>
<description><![CDATA[A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Ion channel assay methods]]></title>
<link>http://www.freepatentsonline.com/7615357.html</link>
<description><![CDATA[A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Aggrecanase structure]]></title>
<link>http://www.freepatentsonline.com/7615363.html</link>
<description><![CDATA[This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[α(1,6)-linked glucose oligosaccharide hydrolyzing enzyme polynucleotides and polypeptides and methods of use thereof]]></title>
<link>http://www.freepatentsonline.com/7615365.html</link>
<description><![CDATA[This invention relates to a method for utilizing less purified starch in fermentation processes. One example is a recombinant  E. coli  containing a exogenous extracellular isoamylase activity that is capable of utilizing small oligomers containing (1,6) linkages (including but not limited to isomaltose and panose) in fermentations to produce useful products. The invention is useful in large-scale industrial biofermentations by reducing the cost of the substrate carbohydrate.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[<i>Streptococcus thermophilus </i>strains producing stable high-molecular-mass exopolysaccharides]]></title>
<link>http://www.freepatentsonline.com/7615367.html</link>
<description><![CDATA[The invention relates to the field of exopolysaccharide producing lactic acid bacteria. The invention relates to methods and culture media for producing large amounts of exopolysaccharides in safe and simple fermentation conditions. The invention more specifically relates to the characterization of a  Streptococcus thermophilus  ST 111 strain producing a stable high-molecular-mass heteropolysaccharide, its use in functional starter cultures and its use in food fermentation processes such as processes producing milk products, yoghurt and cheese for texture improvement and decreasing syneresis during fermentation and in the fermented product.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[System having device for preventing air bubbles in a hybridization chamber and corresponding method]]></title>
<link>http://www.freepatentsonline.com/7615370.html</link>
<description><![CDATA[The present invention relates to a system ( 1 ) having hybridization chambers ( 5 ) for hybridizing nucleic acid samples, proteins, or tissue sections immobilized on slides ( 27 ), each hybridization chamber ( 5 ) being defined as an essentially gap-shaped chamber, which is essentially fillable with a liquid, between one of these slides ( 27 ) and a cover ( 26 ), and the cover ( 26 ) being positioned in relation to the slide ( 27 ) in such a way that the hybridization chamber ( 5 ) is sealed to the surrounding air, the system ( 1 ) including a device for preventing air bubbles in the hybridization chambers ( 5 ). The system according to the present invention is distinguished in that this device for preventing air bubbles in the hybridization chambers ( 5 ) is implemented as a pressure device to build up a chamber pressure in the hybridization chambers ( 5 ), this chamber pressure lying above the normal atmospheric pressure existing in the surrounding air. The present invention additionally relates to a method for preventing air bubbles in the hybridization chambers ( 5 ) of such a system ( 1 ) and is distinguished in that, using a pressure device of this system ( 1 ), a chamber pressure is implemented in the hybridization chambers ( 5 ) which lies above the normal atmospheric pressure existing in the surrounding air.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Particulate construct comprising polyhydroxyalkanoate and method for producing it]]></title>
<link>http://www.freepatentsonline.com/7615233.html</link>
<description><![CDATA[The invention provides a particulate construct comprising a polyhydroxyalkanoate to serve as microcapsules containing a drug, and serving a slow releasing preparation not associated with a practically unacceptable initial burst release but showing a practically acceptable zero-order release for a certain period and a producing method for such particulate construct, and a slow releasing preparation of a high drug content capable of stably incorporating the drug in the particulate construct such as microcapsules, and a producing method for such preparation.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Methods, agents, and compound screening assays for inducing differentiation of undifferentiatied mammalian cells into osteoblasts]]></title>
<link>http://www.freepatentsonline.com/7615626.html</link>
<description><![CDATA[The present invention relates to methods, agents and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts. The invention thus provides a method, comprising contacting a compound with a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID No: 194-309; and measuring a compound-polypeptide property related to the differentiation of said cells. The invention further relates to a bone formation enhancing pharmaceutical composition, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean bone density in a subject. Furthermore, the invention relates to a method for the in vitro production of bone tissue.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Dry bean line 08550813]]></title>
<link>http://www.freepatentsonline.com/7615682.html</link>
<description><![CDATA[The invention provides seed and plants of the dry bean line designated 08550813. The invention thus relates to the plants, seeds and tissue cultures of dry bean line 08550813, and to methods for producing a dry bean plant produced by crossing a plant of dry bean line 08550813 with itself or with another dry bean plant, such as a plant of another line. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of a plant of dry bean line 08550813, including the pods and gametes of such plants.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Dry bean line 08540800]]></title>
<link>http://www.freepatentsonline.com/7615683.html</link>
<description><![CDATA[The invention provides seed and plants of the dry bean line designated 08540800. The invention thus relates to the plants, seeds and tissue cultures of dry bean line 08540800, and to methods for producing a dry bean plant produced by crossing a plant of dry bean line 08540800 with itself or with another dry bean plant, such as a plant of another line. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of a plant of dry bean line 08540800, including the pods and gametes of such plants.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Dry bean line 08530714]]></title>
<link>http://www.freepatentsonline.com/7615684.html</link>
<description><![CDATA[The invention provides seed and plants of the dry bean line designated 08530714. The invention thus relates to the plants, seeds and tissue cultures of dry bean line 08530714, and to methods for producing a dry bean plant produced by crossing a plant of dry bean line 08530714 with itself or with another dry bean plant, such as a plant of another line. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of a plant of dry bean line 08530714, including the pods and gametes of such plants.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Method and apparatus for analysing nucleic acid sequence]]></title>
<link>http://www.freepatentsonline.com/7617054.html</link>
<description><![CDATA[A method of analyzing nucleic acid sequence data produced by automated sequencer comprises scaling the data according to a map of relative heights of homozygous base data. An apparatus for conducting the method comprises means for scaling the data according to a map of relative heights of homozygous base data.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Disease susceptibility gene for rheumatoid arthritis, protein thereof, evaluation method and evaluation kit for evaluating onset possibility of rheumatoid arthritis by using those, and remedy and curing medicine for rheumatoid arthritis]]></title>
<link>http://www.freepatentsonline.com/7615341.html</link>
<description><![CDATA[An gene was identified as a RA disease susceptibility gene on Human Chromosome 8, the gene coding a protein that has an amino acid sequence shown in SEQ. ID NO. 1 and that has such mutation that glycine is inserted as a 269th amino acid in the sequence. Moreover, it was found that mutation of the gene and the protein relate to onset of RA. Achieved is a method of evaluating with high accuracy the onset or onset possibility of RA by using the mutation.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[ACTN3 genotype screen for athletic performance]]></title>
<link>http://www.freepatentsonline.com/7615342.html</link>
<description><![CDATA[The present invention concerns novel methods of selecting or matching a sport or sporting event to an individual (e.g. a sprint/power sport or an endurance sport) and predicting athletic performance, the methods involving assessing ACTN3 genotype. In alternative embodiments, training regimens may be optimally designed for athletes by assessing the ACTN3 genotypes. Certain embodiments concern combining the assessment of the ACTN3 genotype with other known fitness-related genes to better assess the athletic potential of an individual. In addition, the genotypic analysis of the ACTN3 gene may be combined with physiological tests, physical measurements and/or psychological assessments to more optimally design a training regimen for an individual athlete.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Microbial based chlorinated ethene destruction]]></title>
<link>http://www.freepatentsonline.com/7615153.html</link>
<description><![CDATA[A mixed culture of  Dehalococcoides  species is provided that has an ability to catalyze the complete dechlorination of polychlorinated ethenes such as PCE, TCE, cDCE, 1,1-DCE and vinyl chloride as well as halogenated ethanes such as 1,2-DCA and EDB. The mixed culture demonstrates the ability to achieve dechlorination even in the presence of high source concentrations of chlorinated ethenes.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[<i>Bacillus amyloliquefaciens </i>KTGB0202 and control method of plant pathogenic fungi using that]]></title>
<link>http://www.freepatentsonline.com/7615366.html</link>
<description><![CDATA[The present invention relates to a novel microorganism  Bacillus amyloliquefaciens  KTGB0202 and a method for controlling plant pathogens using the same. More particularly, the present invention relates to a novel microorganism  Bacillus amyloliquefaciens  KTGB0202 (accession number: KCTC 10564BP) bacterium which has an excellent control effect against crop powdery mildew and a broad spectrum of antifungal activity against plant pathogenic fungi and inhibits tobacco mosaic virus infection, as well as an eco-friendly bacterial culture broth for controlling powdery mildew, which contains the same. Also, the present invention relates to antifungal substance KTGB0202AFO1 obtained by extraction and purification from the  Bacillus amyloliquefaciens  KTGB0202 bacteria. The inventive  Bacillus amyloliquefaciens  KTGB0202 bacteria have a broad spectrum of antifungal activity, and are excellent in activity continuance and used for controlling various plant pathogens, including powdery mildew.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Detection system for PCR assay]]></title>
<link>http://www.freepatentsonline.com/7615620.html</link>
<description><![CDATA[The present invention provides a detection system for a PCR process using FRET which comprises at least two single-labelled Oligonucleotide sequences of differing Tm that hybridize to one another in free solution to form a fluorescent quenched pair, that upon introduction of a complementary sequence to one or both sequences generates a measurable signal, one of the sequences being of a Tm that is below the Ta of the PCR process, the other not being below the Ta of the PCR process.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Assessment method]]></title>
<link>http://www.freepatentsonline.com/7615677.html</link>
<description><![CDATA[A method of assessing the viability of a cell comprises incubating the cell in a culture medium. The culture medium includes a plurality of amino acids and the change in concentration in the medium of at least one amino acid is determined.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Method for trapping nucleic acids using divalent metal ions]]></title>
<link>http://www.freepatentsonline.com/7615347.html</link>
<description><![CDATA[A method for trapping nucleic acids on a surface of a solid phase substrate, which comprises the step of contacting a sample containing nucleic acids and having a pH of 12 or higher with the surface of the solid phase substrate on which divalent metal ions are immobilized, and a method for trapping nucleic acids on a surface of a solid phase substrate, which comprises the step of contacting a sample containing nucleic acids and a magnesium compound, of which pH is adjusted to be 12 or higher, with the surface of the solid phase substrate.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Electrochemical method to measure DNA attachment to an electrode surface in the presence of molecular oxygen]]></title>
<link>http://www.freepatentsonline.com/7615348.html</link>
<description><![CDATA[The present disclosure provides methods and compositions for conducting an assay to detect a polynucleotide. In particular, ruthenium complexes having reduction potentials that do not coincide with the reduction potential of molecular oxygen are disclosed and amperometric techniques for their use are described. In preferred embodiments, the ruthenium complex is ruthenium (III) pentaamine pyridine and the polynucleotide that is detected is DNA. Further, techniques for enhancing detectable contrast between hybridized and unhybridized nucleic acids are disclosed. In particular, the use of elongated target strands as well as the use of uncharged probe strands are discussed.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Use of <i>Saccharomyces cerevisiae erg4 </i>mutants for expressing mammalian glucose transporter]]></title>
<link>http://www.freepatentsonline.com/7615360.html</link>
<description><![CDATA[The invention relates to yeast strains in which a human GLUT4 transport or a human GLUT1 transporter can be functionally expressed and to particular GLUT4 transport proteins which can be functionally expressed particularly readily in yeast strains.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Methods for treating blood coagulation disorders]]></title>
<link>http://www.freepatentsonline.com/7615537.html</link>
<description><![CDATA[The present invention relates to a method of treating an individual having a blood coagulation defect (e.g., hemophilia A, hemophilia B), comprising administering to the individual an effective amount of a DNA vector encoding modified Factor VII (FVII), wherein the modified Factor VII leads to generation of Factor VIIa in vivo. In a particular embodiment, the invention pertains to a method of treating an individual having a blood coagulation defect comprising administering to the individual an effective amount of a nucleic acid encoding a modified FVII wherein the modified FVII comprises a signal which codes for precursor cleavage by furin at the activation cleavage site of the modified FVII. The invention also relates to a method of treating an individual having a blood coagulation disorder comprising administering to the individual an effective amount of a nucleic acid encoding the light chain of human FVII and a nucleic acid encoding the heavy chain of human FVII operably linked to a leader sequence. Compositions, expression vectors and host cells comprising nucleic acid which encodes a modified Factor VII, wherein the modified Factor VII leads to generation of Factor VIIa in vivo is also encompassed by the present invention.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Electroprocessed collagen and tissue engineering]]></title>
<link>http://www.freepatentsonline.com/7615373.html</link>
<description><![CDATA[The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Method for producing a colorimetric resonant reflection biosensor on rigid surfaces]]></title>
<link>http://www.freepatentsonline.com/7615339.html</link>
<description><![CDATA[The invention provides methods for fabricating calorimetric resonant reflection biosensors.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Polypeptide having activity of unsaturating W3-fatty acid, polynucleotide coding for the polypeptide and use thereof]]></title>
<link>http://www.freepatentsonline.com/7615364.html</link>
<description><![CDATA[The present invention provides a polypeptide having a wide substrate specificity and having a ω3 fatty acid desaturation activity, which makes efficiently unsaturated bond at ω3 position, and a polynucleotide coding for the same. By expressing the polypeptide in the organism, mass production of n-3 series PUFAs is enabled. Specifically, the polypeptide having a ω3 fatty acid desaturation activity and consisting of the amino acid sequence represented by SEQ ID NO: 1, a polynucleotide coding for a polypeptide having a ω3 fatty acid desaturation activity that consists of the base sequence represented by SEQ ID NO: 2 or SEQ ID NO: 3, and the like is useful for production of n-3 series fatty acids.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups]]></title>
<link>http://www.freepatentsonline.com/7615646.html</link>
<description><![CDATA[This invention relates to the functionalized cyanine dyes and more particularly, to the synthesis of chiral 3-substituted 2,3′-dymethyl-3H-indole and its derivatives as intermediates for preparation of cyanine dyes, to methods of preparing these dyes and the dyes so prepared.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Methods for modifying plant responses to stress and correspondingly derived plants]]></title>
<link>http://www.freepatentsonline.com/7615681.html</link>
<description><![CDATA[Plant stresses such as pest drought, and excessive temperatures can lead to significant losses of crops each year. There is a continuing need to develop novel plant varieties that are less susceptible to damage or loss by such stresses. The present invention provides a system and method for generating plants having an increased resistance to plant stresses such as drought or adverse temperatures. Transgenic plants expressing a phosphoinositide-specific phospholipase C (PI-PLC) gene can show an unexpected and dramatic improvement in their capacity to tolerate a variety of stress conditions. Moreover, increased PI-PLC expression can further lead to marked increase in plant growth rates, maturation, and lipid content. The present invention encompasses transgenic plants having modifications with regard to PI-PLC pathways, such as altered PI-PLC levels, and plant products thereof.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Rapid thermal cycling device]]></title>
<link>http://www.freepatentsonline.com/7614444.html</link>
<description><![CDATA[A lid for a well plate is provided. A pin penetrates the lid and projects downwardly into a well of the well plate. An electrical charge is applied to the pin and an electrical charge of opposite polarity is applied to an electrically conductive portion of a corresponding well, generating a small flow of electrical current and corresponding electrical fields within the well. Charged materials, such as DNA, selectably are attracted to the pin and segregated from the liquid sample.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Nucleic acid and corresponding protein entitled 193P1E1B useful in treatment and detection of cancer]]></title>
<link>http://www.freepatentsonline.com/7615379.html</link>
<description><![CDATA[A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 193P1E1B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 193P1E1B can be used in active or passive immunization.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[<i>Arabidopsis </i>derived promoters for regulation of plant expression]]></title>
<link>http://www.freepatentsonline.com/7615624.html</link>
<description><![CDATA[The invention provides a method to identify a plurality of plant promoters having specified characteristics and promoters identified by the method. The plant genus from which at least some of the promoters are derived is  Arabidopsis . Also provided are transgenic plants comprising the genes identified by the methods of the invention.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[In vitro amplification of nucleic acid molecules via circular replicons]]></title>
<link>http://www.freepatentsonline.com/7615625.html</link>
<description><![CDATA[Methods and compositions suitable for accomplishing the in vitro amplification of nucleic acid molecules via enzymatic means are provided. The preferred means employ circular rather than linear replicons. Means for producing such circular replicons from linear reactants are also provided.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Soybean variety 0232405]]></title>
<link>http://www.freepatentsonline.com/7615687.html</link>
<description><![CDATA[The invention relates to the soybean variety designated 0232405. Provided by the invention are the seeds, plants and derivatives of the soybean variety 0232405. Also provided by the invention are tissue cultures of the soybean variety 0232405 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety 0232405 with itself or another soybean variety and plants produced by such methods.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Histological assessment of nuclear pleomorphism]]></title>
<link>http://www.freepatentsonline.com/7616790.html</link>
<description><![CDATA[A method of histological assessment of nuclear pleomorphism to identify potential cell nuclei divides image data into overlapping sub-images. It uses principal component analysis to derive monochromatic image data, followed by Otsu thresholding to produce a binary image. It removes image regions at sub-image boundaries, unsuitably small image regions and holes in relatively large image regions. It then reassembles the resulting sub-images into a single image. Perimeters (P) and areas (A) of image regions which are potential cell nuclei are determined and used in calculating nuclear shape factors P 2 /A. Nuclear pleomorphism is assessed as relatively low, moderate or high according to whether predetermined shape factor thresholds indicate a mean cell nucleus shape factor for an image is relatively low, moderate or high.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Electrical readout of the binding of analyte molecules to probe molecules]]></title>
<link>http://www.freepatentsonline.com/7615343.html</link>
<description><![CDATA[The invention relates to the detection of the binding of analyte molecules, for example biopolymer molecules, to immobilized capture substance molecules. The invention consists in using semiconductor wafers (chips) with electrical circuits in spatial proximity to a surface area coated with capture substance molecules and loading the binding of the analyte molecules to the capture substance molecules with co-bound electrically conductive nanoparticles so that the nanoparticles can act upon the electrical circuits either through changes in the electrical stray capacitance or by generating electric currents, thus making the binding of the analyte molecules electronically detectable.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Detection of Epstein-Barr virus]]></title>
<link>http://www.freepatentsonline.com/7615352.html</link>
<description><![CDATA[The invention provides methods to detect EBV in biological samples using real-time PCR. Primers and probes for the detection of EBV are provided by the invention.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Tivozanib response prediction]]></title>
<link>http://www.freepatentsonline.com/7615353.html</link>
<description><![CDATA[A diagnostic method for predicting quantitatively whether a human tumor will be responsive or resistant (non-responsive) to treatment with the VEGF inhibitor, tivozanib (AV-951), is disclosed. The test is based on application of an algorithm to measurements of expression levels of the genes in a predictive gene set.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use]]></title>
<link>http://www.freepatentsonline.com/7615359.html</link>
<description><![CDATA[The present invention provides processes for determining the molecular weight of glatiramer acetate and other copolymers. The present invention further provides a plurality of molecular weight markers for determining the molecular weight of glatiramer acetate and other copolymers which display linear relationships between molar ellipticity and molecular weight, and between retention time and the log of the molecular weight. The molecular weight markers also optimally demonstrate biological activity similar to glatiramer acetate or corresponding copolymers and can be used for treating or preventing various immune diseases. In addition, the subject invention provides pharmaceutical compositions for the treatment of immune diseases comprising a polypeptide having an identified molecular weight and an amino acid composition corresponding to glatiramer acetate or a terpolymer.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Microarrays of polypeptides]]></title>
<link>http://www.freepatentsonline.com/7615368.html</link>
<description><![CDATA[Microarrays of polypeptides on a solid support are provided. The microarray compositions find use in the multiplexed detection and quantitation of ligands, e.g. antigens or antibodies, in a miniaturized format. The substrate is used for detecting binding of ligands to a plurality of polypeptides for screening and diagnostic purposes.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Polypeptide fragments of hepatitis E virus, the vaccine comprising said fragments and the diagnostic kits]]></title>
<link>http://www.freepatentsonline.com/7615228.html</link>
<description><![CDATA[A purified polypeptide comprising the amino acid sequence as set forth in SEQ ID No. 1 of hepatitis E virus ORF 2 or its fragment, which is in the form of a polymer with n monomeric polypeptides, wherein n is an integer from 2-180; to a polypeptide of the present invention bound to a polypeptide containing epitope from hepatitis E virus ORF3or an immunogenic fragment thereof; to a recombinant expression vector comprising the DNA molecule encoding the above polypeptides and the host cell transformed with said recombinant expression vector which is able to express polypeptide of the present invention. The present invention further relates to a vaccine composition against hepatitis E virus which comprises the above-mentioned polypeptide, or diagnostic kit for hepatitis E virus infection comprising the above-mentioned polypeptide, which includes IgG, IgM, or total antibody diagnostic kit for hepatitis E virus, and to the use of vaccine composition and diagnostic kit for prophylaxis, diagnosis and/or treatment of hepatitis E virus infection.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Glycopeptide and peptide having a <i>kokumi </i>taste imparting function, and method of imparting the <i>kokumi </i>taste to foods]]></title>
<link>http://www.freepatentsonline.com/7615244.html</link>
<description><![CDATA[Glycopeptides and peptides having the formula:  
 
where X represents a hydrogen atom or a sugar chain, provide a taste improving function, particularly a kokumi taste imparting function. Such glycopeptides and peptides may be used to impart the kokumi taste to foods or seasonings and to improve the kokumi taste in foods with the use of seasonings that contain such glycopeptides and peptides.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[High lysine maize compositions and methods for detection thereof]]></title>
<link>http://www.freepatentsonline.com/7615621.html</link>
<description><![CDATA[Disclosed herein are assays for detecting the presence of a lysine-increasing transgenic event based on the DNA sequence of the exogenous DNA construct inserted into the maize genome and of genomic sequences flanking the insertion site. Also provided are transgenic plants having a novel exogenous DNA construct that expresses a dihydrodipicolinic acid synthase, the activity of which results in increased lysine in a plant or plant product.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Methods for using artificial polynucleotides and compositions thereof to reduce transgene silencing]]></title>
<link>http://www.freepatentsonline.com/7615678.html</link>
<description><![CDATA[The materials and methods disclosed provide for polynucleotide molecules sufficiently divergent from polynucleotides naturally contained in plants, or polynucleotides previously introduced into plants as transgenes to permit trait stacking in plant breeding methods or plant transformation methods. The disclosure also provides for methods and compositions to detect the polynucleotides of the invention in plants.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Method of producing polyunsaturated fatty acids, novel biosynthesis genes, and novel plant expression constructs]]></title>
<link>http://www.freepatentsonline.com/7615679.html</link>
<description><![CDATA[The present invention relates to a method for the production of unsaturated fatty acids with at least two double bonds. The invention further relates to the use of the nucleic acid sequence of SEQ ID NO: 1 encoding a polypeptide having delta-5 desaturase activity in the method and for generating a transgenic organism, preferably a transgenic plant or microorganism with an increased content of fatty acids, oil or lipids with unsaturated long chain fatty acids, to their homologs or derivatives, and to gene constructs encompassing these genes. The invention also relates to the use of the nucleic acid sequences alone or in combination with further desaturases and/or elongase genes in the method and for generating transgenic organisms.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Soybean variety D4713125]]></title>
<link>http://www.freepatentsonline.com/7615688.html</link>
<description><![CDATA[The invention relates to the soybean variety designated D4713125. Provided by the invention are the seeds, plants and derivatives of the soybean variety D4713125. Also provided by the invention are tissue cultures of the soybean variety D4713125 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety D4713125 with itself or another soybean variety and plants produced by such methods.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Reconfigurable protein patterning using electrowetting microelectrodes]]></title>
<link>http://www.freepatentsonline.com/7615369.html</link>
<description><![CDATA[A protein patterning electrode device consisting of capacitor microelectrode arrays coated with a protein non-adherent layer is provided. Operation of the electrode is based on a phenomenon called “electrowetting,” where surface wettability can dynamically be controlled by varying the voltage across the device electrodes. When an electric field is applied across the electrode layers, the surface accumulates charge and becomes hydrophilic, binding the proteins to the surface via ionic bonding. Electrically controlling the amount of the surface charge permits controlled protein surface affinity. The device provides a means for reconfigurable protein patterning.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Methods for determining and lowering caffeine concentration in fluids]]></title>
<link>http://www.freepatentsonline.com/7615218.html</link>
<description><![CDATA[Single-chain, camelized heavy chain antibodies immunospecific for caffeine and stable at high temperatures are useful for analysis and recovery of caffeine in or from fluids. A device that provides a single-step lateral flow assay for caffeine and a useful peptide spacer are also described.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Expression and use of novel pesticidal toxins]]></title>
<link>http://www.freepatentsonline.com/7615686.html</link>
<description><![CDATA[A novel pesticidal toxin isolated from  Bacillus thuringiensis  that is highly active against a wide range of lepidopteran insect pests is disclosed. The DNA encoding the pesticidal toxin can be used to transform various prokaryotic and eukaryotic organisms to express the pesticidal toxin. These recombinant organisms can be used to control lepidopteran insects in various environments.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Plants and seeds of hybrid corn variety CH394140]]></title>
<link>http://www.freepatentsonline.com/7615695.html</link>
<description><![CDATA[According to the invention, there is provided seed and plants of the hybrid corn variety designated CH394140. The invention thus relates to the plants, seeds and tissue cultures of the variety CH394140, and to methods for producing a corn plant produced by crossing a corn plant of variety CH394140 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH394140.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Plants and seeds of hybrid corn variety CH160029]]></title>
<link>http://www.freepatentsonline.com/7615696.html</link>
<description><![CDATA[According to the invention, there is provided seed and plants of the hybrid corn variety designated CH160029. The invention thus relates to the plants, seeds and tissue cultures of the variety CH160029, and to methods for producing a corn plant produced by crossing a corn plant of variety CH160029 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH160029.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Plants and seeds of hybrid corn variety CH060503]]></title>
<link>http://www.freepatentsonline.com/7615697.html</link>
<description><![CDATA[According to the invention, there is provided seed and plants of the hybrid corn variety designated CH060503. The invention thus relates to the plants, seeds and tissue cultures of the variety CH060503, and to methods for producing a corn plant produced by crossing a corn plant of variety CH060503 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH060503.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Methods for haplotyping genomic DNA]]></title>
<link>http://www.freepatentsonline.com/7615350.html</link>
<description><![CDATA[The present invention provides a novel method for specifically isolating and separating large segments of genomic DNA that can subsequently be used to determine a genomic haplotype. The invention relies on using a solid phase having a flat surface arrayed with oligonucleotides designed to specifically hybridize to each particular haplotype of an individual sample, e.g., oligonucleotides designed to specifically hybridize with each of the two HLA-B haplotypes, HLA-A, HLA-C, HLA-DR, HLA-DQ, and the like. The genomic DNA is contacted and hybridized to the arrayed oligonucleotides to form a genomic DNA/oligonucleotide complex. The excess genomic DNA is washed away and the haplotype separated genomic DNA is denatured from the oligonucleotide probe and collected. The method of the present invention allows for the separation of genomic DNA fragments of between approximately 2 to about 4 megabases (Mb). Separation of the haplotypes of large genomic DNA fragments allows for linkage analysis of other HLA alleles and polymorphisms, microsatellite, SNPs, and the like across a large span of the HLA region, including HLA-A, -B, -C, and HLA-DRB1 regions. This linkage analysis is particularly useful when HLA typing for an individual with limited family HLA typing available.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Method for determining the concentration of vital epithelial tumor cells in a body fluid]]></title>
<link>http://www.freepatentsonline.com/7615358.html</link>
<description><![CDATA[A method for determining the concentration of vital epithelial tumor cells in a body fluid is disclosed. The method comprises obtaining from the body fluid of a test subject a test specimen, labeling the epithelial tumor cells contained in said test specimen, applying the test specimen to a support, where the epithelial tumor cells adhere and identifying vital cells of the adhering epithelial tumor cells by means of their morphology. The method does not comprise an enrichment of epithelial tumor cells by means of binding to paramagnetic or magnetic particles and applying a magnetic force to the particles.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Method and device for application of thin objects]]></title>
<link>http://www.freepatentsonline.com/7614620.html</link>
<description><![CDATA[The present invention relates to a method of and an apparatus for separation and application of thin objects of a non-porous material or of a material of low porosity on a surface. The invention also relates to a package for the thin objects. With the aid of a pick up and lay down head on an application means a vacuum is applied on a part, preferably the middle, of the uppermost object in a stack of thin objects being in a recess of a package. The recess of the package for receiving the objects is at least areawise somewhat smaller than the exterior dimensions of the objects. With the aid of vacuum in the pick up and lay down head the uppermost object is lifted out of the package. The underlying objects in the stack remain in the package by the friction and scrape effects towards the interior walls of the package. Then the pick up and lay down head of the application means is lowered down so that the object is brought into contact with the surface.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Method and apparatus for detecting estradiol and metabolites thereof using an acoustic device]]></title>
<link>http://www.freepatentsonline.com/7615381.html</link>
<description><![CDATA[Methods for detecting estradiol and metabolites thereof in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for estradiol, is combined with the sample to form a plurality of estradiol-particle complexes. The system also includes a transport arrangement for transporting the sample and/or particles to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of estradiol-particle complexes that are bound to the sensor surface.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Modified trafficking patterns for arrestin and G-protein-coupled receptors via arrestin-ubiquitin chimera]]></title>
<link>http://www.freepatentsonline.com/7615610.html</link>
<description><![CDATA[The present invention relates to a modified arrestin which includes an arrestin molecule and a ubiquitin molecule. This modified arrestin has an increased affinity for a GPCR, and traffics with the GPCR into endosomes. The present invention further relates to a method of screening compounds and sample solutions for a GPCR agonist, antagonist, inverse agonist, or desensitization active compound. The modified arrestin is useful in the methods of the present invention.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Modified interferon beta with reduced immunogenicity]]></title>
<link>http://www.freepatentsonline.com/7615615.html</link>
<description><![CDATA[The present invention relates a modified human interferon beta (INFβ) which is less immunogenic than human INFβ (SEQ ID NO: 1) when administered in vivo to a human. The modified human INFβ comprises an amino acid residue sequence that differs from SEQ ID NO: 1 by an amino acid residue substitution selected from the group consisting of L57A, L57C, L57D L57E, L57G, L57H, L57K, L57N, L57P, L57Q, L57R, L57S, and L57T and an additional substitution selected from the group consisting of the H140A, H140C, H140G, and H140P.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Fuel cell electrode with redox catalyst]]></title>
<link>http://www.freepatentsonline.com/7615293.html</link>
<description><![CDATA[The invention is directed to an electrode, suitable for use in a fuel cell, consisting of a microporous current collector incorporating a multitude of domains and wherein each domain contains soluble redox catalyst.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Transgenic screen and method for screening modulators of brain-derived neurotrophic factor (BDNF) production]]></title>
<link>http://www.freepatentsonline.com/7615676.html</link>
<description><![CDATA[A transgenic screen and method for screening biological and chemical test substances or molecules for their ability to influence or modulate the production of BDNF in cells, includes a fusion gene having a zebrafish BDNF gene fragment (promoter) and a fluorescent marker gene inserted downstream of the BDNF gene fragment. When the fusion gene is injected into a zebrafish embryo, the BDNF promoter causes the production of fluorescent protein in various cell types. The embryo is exposed to a test substance for determining the effect thereof on the production of the fluorescent marker protein.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Container for processing section samples, processing method for section samples, and processing apparatus for section samples]]></title>
<link>http://www.freepatentsonline.com/7616302.html</link>
<description><![CDATA[The container comprises a cylindrical member  20  which constitutes the side wall member, a bottom member  30  which is in contact with the bottom plane of the cylindrical member  20  and which constitutes the bottom part, and an engaged fixing part  35  for engaging the cylindrical member  20  with the bottom member  30 ; the cylindrical member  20  and the bottom member  30  sandwiches the carrier tape T from one side T 1  of the carrier tape T and from the other side T 2  of the carrier tape T, respectively, such that one of the plural thing section samples P 1  may be disposed inside the cylindrical member  20 . Accordingly, without cutting a sequence of tapes carrying thereon the thin section samples of biomedical tissues, each of the thin section samples of the biomedical tissues can be individually processed with different chemicals depending on the required observation for various types of biomedical tissues.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Enriched antibody for detecting mycobacterial infection, methods of use and diagnostic test employing same]]></title>
<link>http://www.freepatentsonline.com/7615222.html</link>
<description><![CDATA[The disclosed technology provides an enriched antibody population, highly specific for an antigen of a surface polysaccharide, from a mycobacterium. In a related embodiment, the antibody is enriched by having been raised in an environment that maintains antigenically active antigen. These antibodies may be used in an immunoreactive environment for detecting the presence of a mycobacterial infection in a sample from a subject.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Methods for treating irritable bowel syndrome]]></title>
<link>http://www.freepatentsonline.com/7615207.html</link>
<description><![CDATA[Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood flow. A method of treating visceral pain or visceral hypersensitivity in a human subject is also described. A method for prolonging the residence time of an orally or enterally administered substance by promoting its dissolution, bioavailability and/or absorption in the small intestine is also described. These methods are related to a method of transmitting to and replicating at a second location in the central nervous system a serotonergic neural signal originating at a first location in the proximal or distal gut of a mammal and/or a method of transmitting to and replicating at a second location in the upper gastrointestinal tract a serotonergic neural signal originating at a first location in the proximal or distal gut.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby]]></title>
<link>http://www.freepatentsonline.com/7615616.html</link>
<description><![CDATA[A bioinformatic method is provided for identifying and isolating proteins with MSCRAMM®—like characteristics from Gram positive bacteria, such as  Enterococcus, Staphylococcus, Streptococcus  and  Bacillus  bacteria, which can then be utilized in methods to prevent and treat infections caused by Gram-positive bacteria. The method involves identifying from sequence information those proteins with a putative C-terminal LPXTG (SEQ ID NO:1) cell wall sorting signal and other structural similarities to MSCRAMM® proteins having the LPXTG-anchored cell wall proteins. The MSCRAMM® proteins and immunogenic regions therein that are identified and isolated using the present invention may be used to generate antibodies useful in the diagnosis, treatment or prevention of Gram positive bacterial infections.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Temporal seed promoters for expressing genes in plants]]></title>
<link>http://www.freepatentsonline.com/7615680.html</link>
<description><![CDATA[The present invention relates to the field of plant genetic engineering. More specifically, the present invention relates to seed specific gene expression during a defined period of embryogenesis. The present invention provides promoters capable of transcribing heterologous nucleic acid sequences in seeds, and methods of modifying, producing, and using the same.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Formulations comprising antisense nucleotides to connexins]]></title>
<link>http://www.freepatentsonline.com/7615540.html</link>
<description><![CDATA[A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful in site specific down regulation of connexin protein expression, particularly in reduction of neuronal cells death, wound healing, reduction of inflammation, decrease of scar formation and skin rejuvenation and thickening.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Antibodies with immune effector activity and that internalize in endosialin-positive cells]]></title>
<link>http://www.freepatentsonline.com/7615372.html</link>
<description><![CDATA[This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and have the ability in the alternative to become internalized by cells expressing endosialin and to induce an immune effector activity such as antibody-dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to endosialin-expressing cells as well as in eliciting an immune-effector activity particularly on tumor and neovascular cells and precursors. The invention is also related to nucleotides encoding the antibodies of the invention, cells expressing the antibodies; methods of detecting cancer and neovascular cells; and methods of treating cancer and neovascular disease using the antibodies, derivatives and fragments.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Antibodies against CCR5 and uses thereof]]></title>
<link>http://www.freepatentsonline.com/7615216.html</link>
<description><![CDATA[Antibodies that specifically bind to CCR5 are useful for treating immunosuppressive disease.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Plants and seeds of corn variety CV988815]]></title>
<link>http://www.freepatentsonline.com/7615694.html</link>
<description><![CDATA[According to the invention, there is provided seed and plants of the corn variety designated CV988815. The invention thus relates to the plants, seeds and tissue cultures of the variety CV988815, and to methods for producing a corn plant produced by crossing a corn plant of variety CV988815 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV988815 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV988815.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Plants and seeds of hybrid corn variety CH946240]]></title>
<link>http://www.freepatentsonline.com/7615692.html</link>
<description><![CDATA[According to the invention, there is provided seed and plants of the hybrid corn variety designated CH946240. The invention thus relates to the plants, seeds and tissue cultures of the variety CH946240, and to methods for producing a corn plant produced by crossing a corn plant of variety CH946240 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH946240.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
</item>

<item>
<title><![CDATA[Bifunctional-modified hydrogels]]></title>
<link>http://www.freepatentsonline.com/7615593.html</link>
<description><![CDATA[Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked using, for example, glutaraldehyde. The hydrogels may also be crosslinked via an interpenetrating network of a photopolymerizable acrylates. The hydrogels may also be modified to have pharmacologically-active agents covalently bonded to the poly(alkylene glycol) molecules or entrained within the hydrogel. Living cells may also be entrained within the hydrogels.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
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<title><![CDATA[Plants and seeds of corn variety EX7834]]></title>
<link>http://www.freepatentsonline.com/7615693.html</link>
<description><![CDATA[According to the invention, there is provided seed and plants of the corn variety designated EX7834. The invention thus relates to the plants, seeds and tissue cultures of the variety EX7834, and to methods for producing a corn plant produced by crossing a corn plant of variety EX7834 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety EX7834 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety EX7834.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
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<title><![CDATA[Methods and compositions for modulating hyperstabilized c-met]]></title>
<link>http://www.freepatentsonline.com/7615529.html</link>
<description><![CDATA[The invention provides methods and compositions for modulating the HGF/c-met signaling pathway, in particular by inhibiting a hyperstabilized c-met protein.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
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<title><![CDATA[Masking background fluorescence and luminescence in the optical analysis of biomedical assays]]></title>
<link>http://www.freepatentsonline.com/7615376.html</link>
<description><![CDATA[In a process for the quantitative optical analysis of fluorescently labelled biological cells  5 , a cell layer on a transparent support at the bottom  2  of a reaction vessel  1  is in contact with a solution  3  containing the fluorescent dye  4 . The sensitivity of analytical detection can be considerably improved if to the fluorescent dye  4  already present in addition a masking dye  9 , which absorbs the excitation light  6  for the fluorescent dye  4  and/or its emission light  7 , is added to the solution  3  and/or if a separating layer  10  permeable to the solution and absorbing and/or reflecting the excitation light  6  or the emission light  7  is applied to the cell layer at the bottom  2 . This process can also be used for improving the sensitivity in the quantitative optical analysis of a luminescent biological cell layer. The separating layer  10  must in this case be composed such that it has a high power of reflection for the luminescent light  11 . Analogously, these process principles can also be used in receptor studies for the masking of the interfering background radiation in the quantitative optical analysis of fluorescently or luminescently labelled reaction components. In this case, a receptor layer  12  at the bottom  2  of a reaction vessel  1  is in contact with a solution (supernatant  3 ) in which a fluorescent or luminescent ligand  13  is dissolved. The sensitivity and accuracy of the analytical detection can be considerably improved here if a masking dye  9  which absorbs the excitation light  6  for the fluorescent dye and/or its emission light or (in the case of luminescent ligands) the luminescent light is added to the supernatant  3 . Instead of the masking dye in the solution  3  or optionally as an additional measure, a separating layer  10  permeable to the solution  3  and absorbing and/or reflecting the excitation light  6  and/or the emission light or the luminescent light can be applied to the cell or receptor layer  12  at the bottom  2.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
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<title><![CDATA[Anti-human VEGF receptor Flt-1 monoclonal antibody]]></title>
<link>http://www.freepatentsonline.com/7615215.html</link>
<description><![CDATA[The present invention provides an antibody or peptide which immunologically reacts with human VEGF receptor Flt-1 and cells in which human VEGF receptor Flt-1 is expressed on the cell surface and an antibody or peptide which inhibits binding of human VEGF to human VEGF receptor Flt-1. It also provides a means for the diagnosis or treatment of diseases in which their morbid states progress by abnormal angiogenesis, such as proliferation or metastasis of solid tumors, arthritis in rheumatoid arthritis, diabetic retinopathy, retinopathy of prematurity, psoriasis, and the like.]]></description>
<pubDate>Tue, 10 Nov 2009 08:00:00 EST</pubDate>
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