Title:

Substituted amides

Document Type and Number:

United States Patent Application 20040058820

Kind Code:

Abstract:

Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.

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Inventors:

Hagmann, William K. (Westfield, NJ, US)
Lin, Linus S. (Westfield, NJ, US)
Shah, Shrenik K. (Metuchen, NJ, US)
Guthikonda, Ravindra N. (Edison, NJ, US)
Qi, Hongbo (Edison, NJ, US)
Chang, Linda L. (Wayne, NJ, US)
Liu, Ping (Edison, NJ, US)
Armstrong, Helen M. (Westfield, NJ, US)
Jewell, James P. (Jersey City, NJ, US)
Thomas Jr., Lanza J. (Edison, NJ, US)

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Application Number:

10/387265

Publication Date:

03/25/2004

Filing Date:

03/12/2003

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Primary Class:

504/260

Other Classes:

564/48, 548/367.100, 504/330, 504/279, 548/318.100, 504/336, 504/280, 504/254, 564/170, 546/298

International Classes:

(IPC1-7): A01N047/28; A01N043/50; C07D233/80; A01N043/56; C07D213/78; C07D231/36; A01N043/40

Attorney, Agent or Firm:

MERCK AND CO INC (P O BOX 2000, RAHWAY, NJ, 070650907)

Claims:

What is claimed is:

1. A compound of structural formula I: 618 embedded image

or a pharmaceutically acceptable salt thereof, wherein; R¹is selected from: (1) C_1-10alkyl, (2) C_3-10cycloalkyl, (3) C_3-10cycloalkyl-C_1-4alkyl, (4) cycloheteroalkyl, (5) cycloheteroalkyl-C_1-4alkyl, (6) aryl, (7) aryl-C_1-4-alkyl, (8) heteroaryl, (9) heteroaryl-C_1-4alkyl, (10) —OR^d, (11) —NR^cR^d, (12) —NR^cC(O)R^d, (13) —CO₂R^d, and (14) —C(O)NR^cR^d, wherein each alkyl, is optionally substituted with one to four substituents independently selected from R^a, and each cycloalkyl, and cycloheteroalkyl, aryl and heteroaryl are optionally substituted with one to four substituents independently selected from R^b; R²is selected from: (1) C_1-10alkyl, (2) C_3-10cycloalkyl-C_1-4alkyl, (3) cycloheteroalkyl, (4) cycloheteroalkyl-C_1-4alkyl, (5) aryl, (6) aryl-C_1-4alkyl, (7) aryloxy, (8) arylthio, (9) heteroaryl, and (10) heteroaryl-C_1-4alkyl, wherein each alkyl, is optionally substituted with one to four substituents independently selected from R^a, and each cycloalkyl, cycloheteroalkyl, aryl and heteroaryl is optionally substituted with one to four substituents independently selected from R^b; R³is selected from: (1) hydrogen, and (2) C_1-4alkyl, wherein each alkyl is optionally substituted with one to four substituents independently selected from R^a; R⁴is selected from: (1) hydrogen, and (2) C_1-4alkyl, wherein each alkyl is optionally substituted with one to four substituents independently selected from R^a; R⁵is selected from: (1) C_1-10alkyl, (2) C_2-10alkenyl, (3) C_3-10cycloalkyl-C_1-4alkyl, (4) cycloheteroalkyl-C_1-4alkyl, (5) aryl-C_1-4alkyl, (6) diaryl-C_1-4alkyl, (7) aryl-C_1-4alkenyl, (8) heteroaryl-C_1-4alkyl, (9) —OR^d, and (10) —NR^cR^d, wherein alkyl, and alkenyl are optionally substituted with one to four substituents independently selected from R^aand cycloalkyl, cycloheteroalkyl, aryl and heteroaryl are optionally substituted with one to four substituents independently selected from R^b, provided that R⁵is not —CH═CH—COOH; each R^ais independently selected from: (1) —OR^d, (2) —NR^cS(O)_mR^d, (3) halogen, (4) —SR^d, (5) —S(O)_mNR^cR^d, (6) —NR^cR^d, (7) —C(O)R^d, (8) —CO₂R^d, (9) —CN, (10) —C(O)NR^cR^d, (11) —NR^cC(O)R^d, (12) —NR^cC(O)OR^d, (13) —NR^cC(O)NR^cR^d, (14) —CF₃, (15) —OCF₃, and (16) cycloheteroalkyl; each R^bis independently selected from: (1) R^a, (2) C_1-10alkyl, (3) oxo, (4) aryl, (5) arylC_1-4alkyl, (6) heteroaryl, and (7) heteroarylC_1-4alkyl; R^cand R^dare independently selected from: (1) hydrogen, (2) C_1-10alkyl, (3) C_2-10alkenyl, (4) cycloalkyl, (5) cycloalkyl-C_1-10alkyl; (6) cycloheteroalkyl, (7) cycloheteroalkyl-C_1-10alkyl; (8) aryl, (9) heteroaryl, (10) aryl-C_1-10alkyl, and (11) heteroaryl-C_1-10alkyl, or R^cand R^dtogether with the atom(s) to which they are attached form a heterocyclic ring of 4 to 7 members containing 0-2 additional heteroatoms independently selected from oxygen, sulfur and N-R^g, each R^cand R^dmay be unsubstituted or substituted with one to three substituents selected from R^h; each R^gis independently selected from (1) C_1-10alkyl, and (2) —C(O)R^c; each R^his independently selected from: (1) halogen, (2) C_1-10alkyl, (3) —O C_1-4alkyl, (4) —S C_1-4alkyl, (5) —CN, (6) —CF₃, and (7) —OCF₃, m is selected from 1 and 2; and provided that: when R¹is unsubstituted phenyl, R²is unsubstituted benzyl, R³is unsubstituted methyl, and R⁴is hydrogen, then R⁵is not unsubstituted methyl; and when R¹is unsubstituted benzyl, R²is unsubstituted phenyl, R³is unsubstituted methyl, and R⁴is hydrogen, then R⁵is not unsubstituted methyl.

2. The compound according to claim 1, wherein R⁴is selected from: (1) hydrogen, and (2) methyl; and pharmaceutically acceptable salts thereof.

3. The compound according to claim 2, wherein R³is selected from hydrogen, methyl and ethyl; and pharmaceutically acceptable salts thereof.

4. The compound according to claim 3, wherein R¹is selected from: (1) C_1-5alkyl, (2) cycloalkyl, (3) cycloheteroalkyl, (4) aryl, (5) aryl-C_1-4alkyl, (6) heteroaryl, (7) heteroaryl-C_1-4alkyl, (8) C_1-5alkyloxy, (9) —OR^d, and (10) —CO₂R^d, wherein each alkyl is optionally substituted with one to three substituents independently selected from R^a, and each aryl and heteroaryl is optionally substituted with one to three substitutents independently selected from R^b; and pharmaceutically acceptable salts thereof.

5. The compound according to claim 3, wherein R²is selected from: (1) C_1-4alkyl, (2) aryl, (3) aryl-C_1-4alkyl, (4) aryloxy, (5) arylthio, (6) heteroaryl, and (7) heteroaryl-C_1-4alkyl, wherein each alkyl is optionally substituted with one R^asubstituent, and each aryl and heteroaryl is optionally substituted with one to three substituents independently selected from R^b; and pharmaceutically acceptable salts thereof.

6. The compound according to claim 3, wherein R⁵is selected from: C_1-8alkyl, (2) C_2-8alkenyl, (3) cycloheteroalkyl-C_1-4alkyl, (4) aryl-C_1-4alkyl, (5) diaryl-C_1-4alkyl, (6) aryl-C_1-4alkenyl, (7) heteroaryl-C_1-4alkyl, (8) —OR^d, (9) —NR^cR^d, wherein each alkyl or alkenyl is optionally substituted with one or two substituents independently selected from R^a, and each cycloalkyl, cycloheteroalkyl, aryl and heteroaryl is each optionally substituted with one to three substituents independently selected from R^band wherein cycloheteroalkyl is selected from pyrrolidinyl, 2H-phthalazinyl, azabicyclo[2.2.1]heptanyl, benzoxapinyl, morpholinyl, piperazinyl, dihydroimidazo[2,1-b]thiazolyl, and piperidinyl; aryl is selected from phenyl and naphthyl; and heteroaryl is selected from pyridyl, pyrazolyl, triazolyl, benzothiazolyl, isoxazolyl, indolyl, benzoxazolinyl, and thiazolyl; provided that R⁵is not —CH═CH—COOH; and pharmaceutically acceptable salts thereof.

7. The compound according to claim 3, selected from: (1) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(pyrazol-1-yl)acetamide, trifluoroacetic acid salt; (2) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(1,2,4-triazol-1-yl)acetamide, trifluoroacetic acid salt; (3) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(benzothiazole-2-thio)acetamide, trifluoroacetic acid salt; (4) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(benzoxazole-2-thio)acetamide, trifluoroacetic acid salt; (5) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(benzoxazolin-2-on-3-yl)acetamide; (6) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(4-methyl-2H-phthalazin-1-on-2-yl)acetamide; (7) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(2H-phthalazin-1-on-4-yl)propanamide; (8) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(3,5-dimethyl-1,2,4-triazol-1-yl)acetamide, trifluoroacetic acid salt; (9) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(2-methyl-thiazol-4-yl)acetamide, trifluoroacetic acid salt; (10) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(1-(4-phenyl-pyrrolidin-2-on-1-yl))acetamide; (11) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(3,5-dimethyl-pyrazol-1-yl)acetamide, trifluoroacetic acid salt; (12) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(3-methyl-pyrazol-1-yl)acetamide, trifluoroacetic acid salt; (13) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(isoindolin-1-on-3-yl)acetamide; (14) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(3,5-dimethyl-isoxazol-4-yl)acetamide, trifluoroacetic acid salt; (15) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(3,5-dimethyl-pyrazol-1-yl)propanamide, trifluoroacetic acid salt; (16) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(3-methyl-pyrazol-1-yl)acetamide, trifluoroacetic acid salt; (17) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(4-(imidazolidin-2-on-1-yl)phenyl)acetamide; (18) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(5-methyl-1,2,4-triazol-3-yl)acetamide, trifluoroacetic acid salt; (19) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-5-(2-methyl)phenyl-5-oxo-pentanamide; (20) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(benzothiazol-2-yl)propanamide, trifluoroacetic acid salt; (21) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(azabicyclo[2.2.1]heptan-2-yl)propanamide, trifluoroacetic acid salt; (22) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(5-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl)acetamide; (23) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(benzotriazol-2-yl)acetamide, trifluoroacetic acid salt; (24) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(4-methyl-thiazol-2-yl-thio)acetamide, trifluoroacetic acid salt; (25) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(4,4-diphenyl)butanamide; (26) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(1,2,4-triazol-1-yl)propanamide, trifluoroacetic acid salt; (27) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(imidazo[2,1-b][1,3]thiazol-6-yl)acetamide, trifluoroacetic acid salt; (28) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(3,5-dichlorophenyl)propanamide; (29) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-4-(3,5-dichlorophenyl)butanamide; (30) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(t-butoxy)propanamide; (31) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-4-(2,3-dihydro-indol-1-yl)butanamide; (32) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(1-methyl-pyrazol-5-yl)propanamide, trifluoroacetic acid salt; (33) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(4-t-butoxyphenyl)propanamide; (34) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(3,5-dimethylphenyl)propanamide; (35) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(5-methyl-pyrazol-1-yl)acetamide, trifluoroacetic acid salt; (36) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(4-methyl-1,2,4-triazol-3-yl-thio)acetamide, trifluoroacetic acid salt; (37) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(2,3,4,5-tetrahydro-1,4-benzoxazepin-4-yl)acetamide, trifluoroacetic acid salt; (38) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-6-(t-butyloxycarbonylamino)hexanamide; (39) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(5,6-dihydro-imidazo[2,1-b]thiazol-3-yl)acetamide, trifluoroacetic acid salt; (40) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(morpholin-4-yl)-2-(3-pyridyl)acetamide, trifluoroacetic acid salt; (41) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-4-(aminosulfonyl)-butanamide; (42) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(4-phenyl-piperazin-1-yl)acetamide, trifluoroacetic acid salt; (43) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-trans-cinnamamide; (44) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-9-phenyl-9-oxo-nonanamide; (45) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-phenyl-butanamide; (46) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-cyclopropyl-acetamide; (47) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(1-naphthyl)-acetamide; (48) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(5-methoxy-1-indanon-3-yl)-acetamide; (49) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-phenoxy-acetamide; (50) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(4-hydroxyphenyl)-propanamide; (51) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-hexanamide; (52) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-cyclopentyl-acetamide; (53) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-ethoxy-acetamide; (54) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-methyl-butanamide; (55) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(1-t-butoxycarbonyl-piperidin-4-yl)-propanamide; (56) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(3-chlorophenyl)-acetamide; (57) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(4-chlorophenyl)-propanamide; (58) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-hydroxy-2-phenyl-acetamide; (59) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-hydroxy-2-(4-methoxy-phenyl)-acetamide; (60) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-methoxy-2-phenyl-acetamide; (61) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-hydroxy-2,2-diphenyl-acetamide; (62) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (63) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-cyclohexyloxy)-2-methylpropanamide; (64) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(2-fluorophenyloxy)-2-methylpropanamide; (65) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3-fluorophenyloxy)-2-methylpropanamide; (66) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3,4-difluorophenyloxy)-2-methylpropanamide; (67) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (68) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(2-chlorophenyloxy)-2-methylpropanamide; (69) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (70) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3-cyanophenyloxy)-2-methylpropanamide; (71) N-[3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (72) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-phenyloxy-2-methylpropanamide; (73) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (74) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2,2-dimethylpropanamide; (75) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-4-chlorophenylcarbamate; (76) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-N′-(4-chlorophenyl)urea; (77) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]benzyl carbamate; (78) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-tert-butylcarbamate^c; (79) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3-pyridyloxy)-2-methylpropanamide; (80) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(2-pyridylox)-2-methylbutanamide; (81) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (82) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-pyridyloxy)-2-methylpropanamide; (83) N-[3,4-bis(4-chlorophenyl)-1-methylpropyl]-2-(2-methoxyphenyloxy)-propanamide; (84) N-[3,4-bis(4-chlorophenyl)-1-methylpropyl]-2-(2-methoxyphenyloxy)-propenamide; (85) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-fluorophenyloxy)-2-methylpropanamide; (86) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-fluorophenyloxy)-2-methylpropanamide; (87) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3,4-difluorophenyloxy)-2-methylpropanamide; (88) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (89) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-chlorophenyloxy)-2-methylpropanamide; (90) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (91) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-cyclohexyloxy-2-methylpropanamide; (92) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (93) N-[3-(4-chlorophenyl)-2-(2-fluorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (94) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (95) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl)]-2-methyl-2-phenylpropanamide; (96) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (97) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (98) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-pyridyloxy)-2-methylpropanamide; (99) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-pyridyloxy)-2-methylbutanamide; (100) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (101) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4-pyridyloxy)-2-methylpropanamide; (102) N-[2-(4-chlorophenyl)-1-methyl-3-phenylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (103) N-[2-(4-chlorophenyl)-1-methyl-3-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (104) N-[3-(4-methoxycarbonylphenyl)-1-methyl-2-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (105) N-[3-(4-methoxycarbonylphenyl)-1-methyl-2-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (106) N-[3-(4-methoxycarbonylphenyl)-1-methyl-2-phenylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (107) N-[2-(2-chlorophenyl)-1-methyl-3-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (108) N-[2-(2-chlorophenyl)-1-methyl-3-phenylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (109) N-[2-(2-chlorophenyl)-1-methyl-3-phenylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (110) N-[2-(4-methoxyphenyl)-1-methyl-3-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (111) N-[2-(4-chlorophenyl )-3-(2,4-dichlorophenyl)-1-methyl-propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (112) N-[2-(4-chlorophenyl)-3-(2,4-dichlorophenyl-1-methyl-propyl]-2,2-dimethylpropanamide; (113) N-[2-(4-chlorophenyl)-2-(4-chloro-2-fluorophenyl)-1-methyl-propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (114) N-[2-(4-chlorophenyl)-2-(4-chloro-2-fluorophenyl)-1-methyl-propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (115) N-[2-(4-chlorophenyl)-2-(4-chloro-2-fluorophenyl)-1-methyl-propyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (116) N-[3-(4-chlorophenyl)-2-(4-fluorophenyl)-1-methyl-propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (117) N-[3-(4-chlorophenyl)-1-methyl-2-(2-pyridyl)propyl]-tert-butylcarbamate; (118) N-[3-(4-chlorophenyl)-1-methyl-2-(2-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (119) N-[3-(4-chlorophenyl)-1-methyl-2-(2-pyridyl)propyl]-2-(4-fluorphenyloxy)-2-methylpropanamide; (120) N-[3-(4-chlorophenyl)-1-methyl-2-(4-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (121) N-[3-(4-cyanophenyl)-1-methyl-2-phenylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (122) N-[3-(5-chloro-2-pyridyl)-1-methyl-2-phenylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (123) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-tert-butylcarbamate; (124) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (125) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (126) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(3-fluorophenyloxy)-2-methylpropanamide; (127) N-[2-(4-chlorophenoxy)-2-(4-chlorophenyl)ethyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (128) N-[2,2-bis(4-chlorophenyl)ethyl]allylcarbamate; (129) N-[2,2-bis(4-chlorophenyl)ethyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (130) N-[2-(4-chlorophenylthio)-2-(4-chlorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (131) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (132) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-phenyloxy)-2-methylpropanamide; (133) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-phenyloxy-2-methylpropanamide; (134) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (135) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(6-methyl-3-pyridyloxy)-2-methylpropanamide; (136) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-fluorophenyloxy)-2-methylpropanamide; (137) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3,4-difluorophenyloxy)-2-methylpropanamide; (138) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (139) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (140) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (141) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (142) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (143) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (144) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (145) N-[3-(4-chlorophenyl)-1-methyl-2-(2-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (146) N-[3-(4-cyanophenyl)-1-methyl-2-phenylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (147) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (148) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (149) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(3-fluorophenyloxy)-2-methylpropanamide; (150) N-[2-(4-chlorophenoxy)-2-(4-chlorophenyl)ethyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (151) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (152) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3,4,5-trifluorophenyloxy)-2-methylpropanamide; (153) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3-chloro-4-fluorophenyloxy)-2-methylpropanamide; (154) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(4-chloro-3-fluorophenyloxy)-2-methylpropanamide; (155) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3,4-dichlorophenyloxy)-2-methylpropanamide; (156) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3,5-dichlorophenyloxy)-2-methylpropanamide; (157) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-3-hydroxy-2,2-dimethylpropanamide; (158) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-3-diethylamino-2,2-dimethylpropanamide; (159) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-3-cyclopropylamino-2,2-dimethylpropanamide; (160) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2,2-dimethyl-3-piperidinylpropanamide; (161) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-3-tert-butylamino-2,2-dimethylpropanamide; (162) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-chlorophenylamino)-2-methylpropanamide; (163) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-pyridyloxy-N-oxide)-2-methylpropanamide; (164) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl-N-oxide)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (165) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl-N-oxide)propyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (166) N-[3-(4-chlorophenyl)-1(S)-methyl-2(S)-phenylpropyl]-2-(4-chloro-3,5-difluorophenyloxy)-2-methylpropanamide; (167) N-[3(R)-(4-chlorophenyl)-1(S),3-dimethyl-2(S)-phenylbutyl]-2-(3,5-difluoro-4-methylphenyloxy)-2-methylpropanamide; (168) N-[3(S)-(4-chlorophenyl)-1(S),3-dimethyl-2(S)-phenylbutyl]-2-(3,5-difluoro-4-methylphenyloxy)-2-methylpropanamide; (169) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(6-methyl-3-pyridyloxy)-2-methylpropanamide; (170) N-[3-(4-chlorophenyl)-2-phenyl-1-methylpropyl]-2-(6-methyl-3-pyridyloxy)-2-methylpropanamide; (171) N-(1,4-dimethyl-2-phenylpentyl)-2-(4-chlorophenoxy)-2-methylpropanamide; (172) N-(1-methyl-2-phenylpentyl)-2-(4-chlorophenoxy)-acetamide; (173) N-(1-methyl-2,5-diphenylpentyl)-2-(4-chlorophenoxy)-acetamide; (174) N-(1,3-dimethyl-2-phenylbutyl)-2-(4-chlorophenoxy)-propanamide; (175) N-(2,3-diphenyl-1-methylpropyl)-2-(4-chlorophenoxy)-2-methylpropanamide; (176) N-(2,3-diphenyl-1-ethylpropyl)-2-(4-chlorophenoxy)-2-methylpropanamide; (177) N-(3-(4-chlorophenyl)-2-phenyl-1-methylpropyl)-2-(4-chlorophenoxy)-acetamide; (178) N-(2,3-diphenyl-1-methylpropyl)-2-(4-chlorophenoxy)-acetamide; (179) N-(3-(4-chlorophenyl)-2-phenyl-1-methylpropyl)-2-(4-chlorophenoxy)-propanamide; (180) N-(2,3-diphenyl-1-methylpropyl)-2-(4-chlorophenoxy)-propanamide; (181) N-(2,3-bis(4-chlorophenyl)-1-methylpropyl)-2-methyl-3-phenyl-propanamide; (182) N-(2,3-bis(4-chlorophenyl)-1-methylpropyl)-2-methyl-3-(4-chlorophenyl)-propanamide; (183) N-(3-(4-chlorophenyl)-2-phenyl-1-methylpropyl)-2-(4-chloro-anilino)-acetamide; (184) N-(2,3-diphenyl-1-methylpropyl)-2-(4-chloro-anilino)-acetamide; (185) N-(2,3-bis(4-chlorophenyl)-1-methylpropyl)-2,2-dimethyl-3-phenyl-propanamide; (186) N-(3-(4-chlorophenyl)-2-phenyl)-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-propanamide; (187) N-(3-(2-chlorophenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-propanamide; (188) N-(3-(4-trifluoromethylphenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-propanamide; (189) N-(3-(4-fluorophenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-propanamide; (190) N-(3-(4-chlorophenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-phenoxy-propanamide; (191) N-(3-(4-chlorophenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-(4-fluorophenoxy)-propanamide; (192) N-(2,3-diphenyl-1-methylpropyl)-2-methyl-2-(4-fluorophenoxy)-propanamide; (193) N-(3-phenyl-2-benzyl-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-propanamide; (194) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (195) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-methyl-2-(3,4,5-trifluorophenyloxy)propanamide; (196) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (197) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (198) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-(3,5-dichlorophenyloxy)-2-methylpropanamide; (199) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (200) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-(3-chloro-5-fluorophenyloxy)-2-methylpropanamide; (201) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (202) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3-chloro-5-fluorophenyloxy)-2-methylpropanamide; (203) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (204) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (205) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (206) N-[2-(3-chlorophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (207) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (208) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-methyl-2-(3,4,5-trifluorophenyloxy)propanamide; (209) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (210) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (211) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-(3,5-dichlorophenyloxy)-2-methylpropanamide; (212) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (213) N-[2-(3-bromophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (214) N-[3-(4-chlorophenyl)-2-(3-iodophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (215) N-[2-(3-bromophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (216) N-[3-(4-chlorophenyl)-2-(3-iodophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (217) N-[2-(3-bromophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-methyl-2-(2-phenyloxy)propanamide; (218) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (219) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3-chloro-5-fluorophenyloxy)-2-methylpropanamide; (220) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (221) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (222) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (223) N-[2-(3-chlorophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (224) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(5-chloropyridyloxy)-2-methylpropanamide; (225) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(6-methylpyridyloxy)-2-methylpropanamide; (226) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-chloro-5-fluorophenyloxy)-2-methylpropanamide; (227) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-pyridazinyloxy)-2-methylpropanamide; (228) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4-trifluoromethylphenyloxy)-2-methylpropanamide; (229) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(5-trifluoromethylpyridyloxy)-2-methylpropanamide; (230) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4,6-dimethylpyridyloxy)-2-methylpropanamide; (231) N-(3-(4-chlorophenyl)-2-cyclopentyl-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (232) N-(3-(4-chlorophenyl)-2-cyclopentyl-1-methyl)propyl-2-(3,5-difluorophenoxy)-2-methylpropanamide; (233) N-(3-(4-chlorophenyl)-2-ethoxy-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (234) N-(3-(4-chlorophenyl)-2-isopropyl-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (235) N-(3-(4-chlorophenyl)-1-methyl-2-propoxy)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (236) N-(3-(4-chlorophenyl)-1-methyl-2-pentoxy)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (237) N-(3-(4-chlorophenyl)-2-cyclopentylmethoxy-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (238) N-(3-(4-chlorophenyl)-2-cyclobutylmethoxy-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (239) N-(3-(4-chlorophenyl)-2-ethyl-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (240) N-(3-(4-chlorophenyl)-2-methoxy-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (241) N-(3-(4-chlorophenyl)-2-pyrrolidin-N-yl-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (242) N-(3-(4-chlorophenyl)-2-benzyloxycarbonyl-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (243) N-(2-(1-(1,2,3-triazolyl))-3-(4-chlorophenyl)-1-methylpropyl)-2-(4-chlorophenyloxy)-2-methylpropanamide; (244) N-(2-(1-(1,2,4-triazolyl))-3-(4-chlorophenyl)-1-methylpropyl)-2-(2-pyridyloxy)-2-methylpropanamide; (245) N-[3-(5-chloro-2-pyridyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(5-chloro-2-pyridyloxy)-2-methylpropanamide; (246) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3-trifluoromethylphenyloxy)-2-methylpropanamide; (247) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(6-chloro-2-pyridyloxy)-2-methylpropanamide; (248) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(4-cyanophenyloxy)-2-methylpropanamide; (249) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3-cyanophenyloxy)-2-methylpropanamide; (250) N-[3-(5-chloro-2-pyridyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (251) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(5-chloro-2-pyrimidyloxy)-2-methylpropanamide; (252) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(2-pyrimidyloxy)-2-methylpropanamide; (253) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(4-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (254) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(4-trifluoromethyl-2-pyrimidyloxy)-2-methylpropanamide; (255) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(4-pyrimidyloxy)-2-methylpropanamide; (256) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2(R)-(4-trifluoromethyl-2-pyridyloxy)propanamide; (257) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(4-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (258) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(5-chloro-2-pyridyloxy)-2-methylpropanamide; (259) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (260) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (261) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(4-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (262) N-[2-(3-bromo-5-fluorophenyl)-3-(4-fluorophenyl)-1-methylpropyl-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (263) N-[2-(3-bromo-5-fluorophenyl)-3-(4-fluorophenyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (264) N-[2-(3-chlorophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-(5-chloro-2-pyridyloxy)-2-methylpropanamide; (265) N-[2-(3-chlorophenyl)-3-(5-chloro-2-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (266) N-[2-(3-chlorophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (267) N-[2-(3-bromophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (268) N-[2-(3-bromophenyl)-3-(5-chloro-2-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (269) N-[3-(4-chlorophenyl)-2-(3-trifluoromethylphenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (270) N-[3-(4-chlorophenyl)-2-(3-methylphenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (271) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(5-chloro-2-pyridyloxy)-2-methylpropanamide; (272) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (273) N-[3-(5-chloro-2-pyridyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (274) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (275) N-[3-(4-chlorophenyl)-2-(2-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (276) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (277) N-[3-(4-chlorophenyl)-2-(5-fluoro-3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (278) N-[3-(4-chlorophenyl)-2-(5-fluoro-3-pyridyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (279) N-[3-(4-chlorophenyl)-2-(5-chloro-3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (280) N-[3-(4-chlorophenyl)-2-(5-chloro-3-pyridyl)-1-methylpropyl]-2-(4-trifluoromethyl-2-pyrimidyloxy)-2-methylpropanamide; (281) N-[3-(4-chlorophenyl)-2-(5-chloro-3-pyridyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (282) N-[3-(4-chlorophenyl)-2-(5-chloro-3-pyridyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyridyloxy)-2-methylpropanamide; (283) N-[2-(5-chloro-3-pyridyl)-3-cyclobutyl-1-methylpropyl]-2-(6-trifluoromethyl-4-pyridyloxy)-2-methylpropanamide; (284) N-[2-(5-chloro-3-pyridyl)-3-cyclobutyl-5-methyl-2-hexyl]-2-(6-trifluoromethyl-4-pyridyloxy)-2-methylpropanamide; (285) N-[3-(4-chlorophenyl)-2-(5-cyano-3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (286) N-[3-(4-chlorophenyl)-2-(5-cyano-3-pyridyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (287) N-[3-(4-chlorophenyl)-2-(5-cyano-3-pyridyl)-1-methylpropyl]-2-(4-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (288) N-[2-(5-bromo-3-pyridyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (289) N-[2-(5-bromo-3-pyridyl)-3-(4-fluorophenyl)-1-methylpropyl]-2-(4-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (290) N-[2-(5-bromo-3-pyridyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-(4-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (291) N-[2-(5-bromo-3-pyridyl)-3-(4-fluorophenyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (292) N-[2-(5-bromo-3-pyridyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (293) N-[3-(4-chlorophenyl)-2-(5-methyl-3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (294) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(5-chloro-2-pyridyloxy)-2-methylpropanamide; (295) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(5-chloro-2-pyridyloxy)-2-methylpropanamide; (296) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (297) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (298) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(4-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (299) N-[2-(3-chlorophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-(5-chloro-2-pyridyloxy)-2-methylpropanamide; (300) N-[2-(3-chlorophenyl)-3-(5-chloro-2-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (301) N-[2-(3-chlorophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (302) N-[2-(3-bromophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-(5-chloro-2-pyridyloxy)-2-methylpropanamide; (303) N-[2-(3-bromophenyl)-3-(5-chloro-2-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (304) N-[3-(4-chlorophenyl)-2-(3-trifluoromethylphenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (305) N-[3-(4-chlorophenyl)-2-(3-methylphenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (306) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(5-chloro-2-pyridyloxy)-2-methylpropanamide; (307) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (308) N-[3-(4-chlorophenyl)-2-(2-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (309) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (310) N-[3-(4-chlorophenyl)-2-(5-fluoro-3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (311) N-[3-(4-chlorophenyl)-2-(5-fluoro-3-pyridyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (312) N-[3-(4-chlorophenyl)-2-(5-chloro-3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (313) N-[3-(4-chlorophenyl)-2-(5-chloro-3-pyridyl)-1-methylpropyl]-2-(4-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (314) N-[3-(4-chlorophenyl)-2-(5-chloro-3-pyridyl)-1-methylpropyl]-2-(4-trifluoromethyl-2-pyrimidyloxy)-2-methylpropanamide; (315) N-[3-(4-chlorophenyl)-2-(5-chloro-3-pyridyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (316) N-[2-(5-chloro-3-pyridyl)-3-(4-fluorophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-4-pyridyloxy)-2-methylpropanamide; (317) N-[2-(5-chloro-3-pyridyl)-3-cyclobutyl-1-methylpropyl]-2-(5-trifluoromethyl-4-pyridyloxy)-2-methylpropanamide; (318) N-[2-(5-chloro-3-pyridyl)-3-cyclobutyl-1-methylpropyl]-2-(5-trifluoromethyl-4-pyridyloxy)-2-methylpropanamide; (319) N-[2-(5-chloro-3-pyridyl)-1,4-dimethylpentyl]-2-(5-trifluoromethyl-4-pyridyloxy)-2-methylpropanamide; (320) N-[2-(5-chloro-3-pyridyl)-1,4-dimethylpentyl]-2-(5-trifluoromethyl-4-pyridyloxy)-2-methylpropanamide; (321) N-[3-(4-chlorophenyl)-2-(5-cyano-3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (322) N-[3-(4-chlorophenyl)-2-(5-cyano-3-pyridyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (323) N-[2-(5-cyano-3-pyridyl)-3-(3,4-difluorophenyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (324) N-[3-(3-chlorophenyl)-2-(5-cyano-3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (325) N-[2-(5-cyano-3-pyridyl)-3-(4-fluorophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (326) N-[2-(5-bromo-3-pyridyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (327) N-[2-(5-bromo-3-pyridyl)-3-(4-fluorophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (328) N-[2-(5-bromo-3-pyridyl)-3-(4-fluorophenyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (329) N-[2-(5-bromo-3-pyridyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (330) N-[3-(4-chlorophenyl)-2-(5-methyl-3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (331) N-[2-(3-bromophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-(5-chloro-2-pyridyloxy)-2-methylpropanamide; (332) N-[3-(4-chlorophenyl)-2-(3-cyano-5-fluorophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (333) N-[2-(3-cyano-5-fluorophenyl)-3-(4-fluorophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (334) N-[2-(3-cyano-5-fluorophenyl)-3-(4-fluorophenyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (335) N-[3-(4-chlorophenyl)-2-(3-cyano-5-fluorophenyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (336) N-[3-(5-chloro-2-pyridyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (337) N-[2-(5-chloro-3-pyridyl)-3-(4-chloro-3-iodophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (338) N-[3-(4-chloro-3-iodophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (339) N-(3-(4-chlorophenyl)-2-benzisoxazol-3-yl)-1-methyl)propyl-2-(5-chloro-2-oxypyridine-2-yl)-2-methylpropanamide; (340) N-(3-(4-chlorophenyl)-2-(benzisoxazol-3-yl)-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (341) N-(3-(4-chlorophenyl)-2-(benzisoxazol-3-yl)-1-methyl)propyl-2-(5-trifluoromethyl-2-oxypyridine-2-yl)-2-methylpropanamide; (342) N-(3-(4-chlorophenyl)-2-(7-azaindol-N-yl)-1-methyl)propyl-2-(5-trifluoromethyl-2-oxypyridine-2-yl)-2-methylpropanamide; (343) N-(3-(4-chlorophenyl)-2-(N-methyl-N-phenyl)amino-1-methyl)propyl-2-(5-trifluoromethyl-2-oxypyridine-2-yl)-2-methylpropanamide; (344) N-(3-(4-chlorophenyl)-2-(indol-N-yl)-1-methyl)propyl-2-(5-trifluoromethyl-2-oxypyridine-2-yl)-2-methylpropanamide; (345) N-(3-(4-chlorophenyl)-2-(indolin-N-yl)-1-methyl)propyl-2(4-trifluoromethyl-2-oxypyridine-2-yl)-2-methylpropanamide; (346) N-(3-(4-chlorophenyl)-2-(indolin-N-yl)-1-methyl)propyl-2(5-trifluoromethyl-2-oxypyridine-2-yl)-2-methylpropanamide; (347) 2-methyl-N-[1-methyl-3-(4-methylphenyl)-2-phenylpropyl]-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide; (348) N-[3-(4-methoxyphenyl)-1-methyl-2-phenylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide; (349) N-[3-(4-fluorophenyl)-1-methyl-2-phenylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide; (350) N-[3-(4-cyanophenyl)-1-methyl-2-phenylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide; (351) N-[2-(3-cyanophenyl)-3-(4-fluorophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide; (352) N-(2-(1H-1,2,3-benzotriazol-1-yl)-3-(4-chlorophenyl)-1-methylpropyl)-2-methyl-2-(5-chloropyridin-2-yl)oxy)-2-methylpropanamide; (353) N-(2-(1H-1,2,3-benzotriazol-1-yl)-3-(4-chlorophenyl)-1-methylpropyl)-2-methyl-2-(5-trifluoromethylpyridin-2-yl)oxy)-2-methylpropanamide; (354) N-(2-(1H-1,2,3-benzotriazol-1-yl)-3-(4-chlorophenyl)-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-2-methylpropanamide; (355) N-(3-(4-chlorophenyl)-1-methyl-2-(1H-indazol-1-yl)propyl)-2-methyl-2-(5-trifluoromethylpyridin-2-yl)oxy)-2-methylpropanamide; (356) N-(3-(4-chlorophenyl)-1-methyl-2-(1-methyl-1H-indol-3-yl)propyl)-2-methyl-2-(5-chloropyridin-2-yl)oxy)-2-methylpropanamide; (357) N-(3-(4-chlorophenyl)-1-methyl-2-(1-methyl-1H-indol-3-yl)propyl)-2-methyl-2-(5-trifluoromethylpyridin-2-yl)oxy)-2-methylpropanamide; (358) N-(3-(4-chlorophenyl)-1-methyl-2-(1-methyl-1H-indol-3-yl)propyl)-2-methyl-2-(4-chlorophenoxy)-2-methylpropanamide; (359) N-(3-(4-chlorophenyl)-1-methyl-2-(1-methyl-1H-indol-4-yl)propyl)-2-methyl-2-(5-trifluoromethylpyridin-2-yl)oxy)-2-methylpropanamide; (360) N-(3-(4-chlorophenyl)-1-methyl-2-(thiophen-2-yl)propyl)-2-methyl-2-(5-chloropyridin-2-yl)oxy)-2-methylprpoanamide; (361) N-(3-(4-chlorophenyl)-1-methyl-2-(thiophen-3-yl)propyl)-2-methyl-2-(5-chloropyridin-2-yl)oxy)-2-methylprpoanamide; (362) N-(3-(4-chlorophenyl)-1-methyl-2-(pyrimidin-5-yl)propyl)-2-methyl-2-(5-chloropyridin-2-yl)oxy)-2-methylprpoanamide; (363) N-(3-(4-chlorophenyl)-1-methyl-2-(pyradizin-3-yl)propyl)-2-methyl-2-(5-chloropyridin-2-yl)oxy)-2-methylprpoanamide; (364) N-(2-(3-cyanophenyl)-3-cyclopropyl-1-methylpropyl)-2-methyl-2((5-(trifluoromethyl)pyridin-2-yl)oxy)-propanamide; (365) N-(2-(3-cyanophenyl)-1,4-dimethylpentyl)-2-methyl-2((5-(trifluoromethyl)pyridin-2-yl)oxy)-propanamide; (366) N-(2-(3-cyanophenyl)-3-cyclobutyl-1-methylpropyl)-2-methyl-2((5-(trifluoromethyl)pyridin-2-yl)oxy)-propanamide; (367) N-(2-(3-cyanophenyl)-3-cyclohexyl-1-methylpropyl)-2-methyl-2((5-(trifluoromethyl)pyridin-2-yl)oxy)-propanamide; (368) N-(2-(3-cyanophenyl)-3-cyclopentyl-1-methylpropyl)-2-methyl-2((5-(trifluoromethyl)pyridin-2-yl)oxy)-propanamide; (369) N-(2-(3-cyanophenyl)-3-((1-tertbutyloxycarbonyl)piperidin-4-yl)-1-methylpropyl)-2-methyl-2((5-(trifluoromethyl)pyridin-2-yl)oxy)-propanamide; (370) N-(2-(2,3-dihydro-1H-indol-1-yl)-1,4-dimethylpentyl)-2-methyl-2((5-(trifluoromethyl)pyridin-2-yl)oxy)-propanamide; (371) N-(3-cyclobutyl-2-(3,4-dihydroquinolin-1(2H)-yl)-1-methylpropyl)-2-methyl-2((5(trifluoromethyl)pyridin-2-yl)oxy)-propanamide; (372) N-(2-(3,4-dihydroquinolin-1(2H)-yl)-1,4-dimethylpentyl)-2-methyl-2((5-(trifluoromethyl)pyridin-2-yl)oxy)-propanamide; (373) N-(2-(3-cyanophenyl)-1,4-dimethylpentyl)-2-methyl-2((5-(trifluoromethyl)pyridin-2-yl)oxy)-propanamide; (374) N-(2-(3-cyanophenyl)-3-cyclobutyl-1-methylpropyl)-2-methyl-2((5-(trifluoromethyl)pyridin-2-yl)oxy)-propanamide; (375) N-(2-(3-cyanophenyl)-3-cyclopentyl-1-methylpropyl)-2-methyl-2((5-(trifluoromethyl)pyridin-2-yl)oxy)-propanamide; (376) N-(2-(3-cyanophenyl)-3-cyclohexyl-1-methylpropyl)-2-methyl-2((5-(trifluoromethyl)pyridin-2-yl)oxy)-propanamide; and pharmaceutically acceptable salts thereof.

8. The compound according to claim 3, selected from: (1) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(pyrazol-1-yl)acetamide; (2) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]2-(1,2,4-triazol-1-yl)acetamide; (3) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(benzothiazole-2-thio)acetamide; (4) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(benzoxazole-2-thio)acetamide; (5) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(benzoxazolin-2-on-3-yl)acetamide; (6) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(4-methyl-2H-phthalazin-1-on-2-yl)acetamide; (7) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(2H-phthalazin-1-on-4-yl)propanamide; (8) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(3,5-dimethyl-1,2,4-triazol-1-yl)acetamide; (9) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(2-methyl-thiazol-4-yl)acetamide; (10) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(1-(4-phenyl-pyrrolidin-2-on-1-yl))acetamide; (11) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(3,5-dimethyl-pyrazol-1-yl)acetamide; (12) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(3-methyl-pyrazol-1-yl)acetamide; (13) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(isoindolin-1-on-3-yl)acetamide; (14) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(3,5-dimethyl-isoxazol-4-yl)acetamide; (15) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(3,5-dimethyl-pyrazol-1-yl)propanamide; (16) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(3-methyl-pyrazol-1-yl)acetamide; (17) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(4-(imidazolidin-2-on-1-yl)phenyl)acetamide; (18) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(5-methyl-1,2,4-triazol-3-yl)acetamide; (19) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-5-(2-methyl)phenyl-5-oxo-pentanamide; (20) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(benzothiazol-2-yl)propanamide; (21) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(azabicyclo[221]heptan-2-yl)propanamide; (22) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(5-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl)acetamide; (23) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(benzotriazol-2-yl)acetamide; (24) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(4-methyl-thiazol-2-yl-thio)acetamide; (25) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(4,4-diphenyl)butanamide; (26) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(1,2,4-triazol-1-yl)propanamide; (27) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(imidazo[2,1-b][1,3]thiazol-6-yl)acetamide; (28) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(3,5-dichlorophenyl)propanamide; (29) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-4-(3,5-dichlorophenyl)butanamide; (30) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(t-butoxy)propanamide; (31) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-4-(2,3-dihydro-indol-1-yl)butanamide; (32) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(1-methyl-pyrazol-5-yl)propanamide; (33) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(4-t-butoxyphenyl)propanamide; (34) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(3,5-dimethylphenyl)propanamide; (35) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(5-methyl-pyrazol-1-yl)acetamide; (36) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(4-methyl-1,2,4-triazol-3-yl-thio)acetamide; (37) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(2,3,4,5-tetrahydro-1,4-benzoxazepin-4-yl)acetamide; (38) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-6-(t-butyloxycarbonylamino)hexanamide; (39) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(5,6-dihydro-imidazo[2,1-b]thiazol-3-yl)acetamide; (40) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(morpholin-4-yl)2-(3-pyridyl)acetamide; (41) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-4-(aminosulfonyl)-butanamide; (42) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(4-phenyl-piperazin-1-yl)acetamide; (43) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-trans-cinnamamide; (44) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-9-phenyl-9-oxo-nonanamide; (45) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-phenyl-butanamide; (46) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-cyclopropyl-acetamide; (47) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(1-naphthyl)-acetamide; (48) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(5-methoxy-1-indanon-3-yl)-acetamide; (49) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-phenoxy-acetamide; (50) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(4-hydroxyphenyl)-propanamide; (51) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-hexanamide; (52) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-cyclopentyl-acetamide; (53) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-ethoxy-acetamide; (54) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-methyl-butanamide; (55) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(1-t-butoxycarbonyl-piperidin-4-yl)-propanamide; (56) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-(3-chlorophenyl)-acetamide; (57) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-3-(4-chlorophenyl)-propanamide; (58) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-hydroxy-2-phenyl-acetamide; (59) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-hydroxy-2-(4-methoxy-phenyl)acetamide; (60) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-methoxy-2-phenyl-acetamide; (61) N-[2,3-bis(4-chlorophenyl)-1-methyl-propyl]-2-hydroxy-2,2-diphenyl-acetamide; (62) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (63) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-cyclohexyloxy)-2-methylpropanamide; (64) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(2-fluorophenyloxy)-2-methylpropanamide; (65) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3-fluorophenyloxy)-2-methylpropanamide; (66) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3,4-difluorophenyloxy)-2-methylpropanamide; (67) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (68) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(2-chlorophenyloxy)-2-methylpropanamide; (69) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (70) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3-cyanophenyloxy)-2-methylpropanamide; (71) N-[3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (72) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-phenyloxy-2-methylpropanamide; (73) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (74) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2,2-dimethylpropanamide; (75) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-4-chlorophenylcarbamate; (76) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-N′-(4-chlorophenyl)urea; (77) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]benzyl carbamate; (78) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-tert-butylcarbamate; (79) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3-pyridyloxy)-2-methylpropanamide; (80) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(2-pyridylox)-2-methylbutanamide; (81) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-pyridyloxy)-2-methylpropanamide; (82) N-[3,4-bis(4-chlorophenyl)-1-methylpropyl]-2-(2-methoxyphenyloxy)-propenamide; (83) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-fluorophenyloxy)-2-methylpropanamide; (84) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-fluorophenyloxy)-2-methylpropanamide; (85) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3,4-difluorophenyloxy)-2-methylpropanamide; (86) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (87) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-chlorophenyloxy)-2-methylpropanamide; (88) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (89) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-cyclohexyloxy-2-methylpropanamide; (90) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (91) N-[3-(4-chlorophenyl)-2-(2-fluorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (92) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (93) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl)]-2-methyl-2-phenylpropanamide; (94) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (95) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (96) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-pyridyloxy)-2-methylbutanamide; (97) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (98) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4-pyridyloxy)-2-methylpropanamide; (99) N-[2-(4-chlorophenyl)-1-methyl-3-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (100) N-[3-(4-methoxycarbonylphenyl)-1-methyl-2-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (101) N-[3-(4-methoxycarbonylphenyl)-1-methyl-2-phenylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (102) N-[2-(2-chlorophenyl)-1-methyl-3-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (103) N-[2-(2-chlorophenyl)-1-methyl-3-phenylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (104) N-[2-(4-methoxyphenyl)-1-methyl-3-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (105) N-[2-(4-chlorophenyl)-3-(2,4-dichlorophenyl)-1-methyl-propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (106) N-[2-(4-chlorophenyl)-3-(2,4-dichlorophenyl)-1-methyl-propyl]-2,2-dimethylpropanamide; (107) N-[2-(4-chlorophenyl)-2-(4-chloro-2-fluorophenyl)-1-methyl-propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (108) N-[2-(4-chlorophenyl)-2-(4-chloro-2-fluorophenyl)-1-methyl-propyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (109) N-[3-(4-chlorophenyl)-2-(4-fluorophenyl)-1-methyl-propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (110) N-[3-(4-chlorophenyl)-1-methyl-2-(2-pyridyl)propyl]-tert-butylcarbamate; (111) N-[3-(4-chlorophenyl)-1-methyl-2-(2-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (112) N-[3-(4-chlorophenyl)-1-methyl-2-(4-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (113) N-[3-(4-cyanophenyl)-1-methyl-2-phenylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (114) N-[3-(5-chloro-2-pyridyl)-1-methyl-2-phenylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (115) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-tert-butylcarbamate; (116) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (117) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (118) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(3-fluorophenyloxy)-2-methylpropanamide; (119) N-[2-(4-chlorophenoxy)-2-(4-chlorophenyl)ethyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (120) N-[2,2-bis(4-chlorophenyl)ethyl]allylcarbamate; (121) N-[2,2-bis(4-chlorophenyl)ethyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (122) N-[2-(4-chlorophenylthio)-2-(4-chlorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (123) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (124) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-phenyloxy)-2-methylpropanamide; (125) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (126) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(6-methyl-3-pyridyloxy)-2-methylpropanamide; (127) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-fluorophenyloxy)-2-methylpropanamide; (128) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3,4-difluorophenyloxy)-2-methylpropanamide; (129) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (130) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (131) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (132) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (133) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (134) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (135) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (136) N-[3-(4-chlorophenyl)-1-methyl-2-(2-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (137) N-[3-(4-cyanophenyl)-1-methyl-2-phenylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (138) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (139) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (140) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(3-fluorophenyloxy)-2-methylpropanamide; (141) N-[2-(4-chlorophenoxy)-2-(4-chlorophenyl)ethyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (142) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (143) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3,4,5-trifluorophenyloxy)-2-methylpropanamide; (144) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3-chloro-4-fluorophenyloxy)-2-methylpropanamide; (145) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(4-chloro-3-fluorophenyloxy)-2-methylpropanamide; (146) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3,4-dichlorophenyloxy)-2-methylpropanamide; (147) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3,5-dichlorophenyloxy)-2-methylpropanamide; (148) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-3-hydroxy-2,2-dimethylpropanamide; (149) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-3-diethylamino-2,2-dimethylpropanamide; (150) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-3-cyclopropylamino-2,2-dimethylpropanamide; (151) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-3-tert-butylamino-2,2-dimethylpropanamide; (152) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-chlorophenylamino)-2-methylpropanamide; (153) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-pyridyloxy-N-oxide)-2-methylpropanamide; (154) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl-N-oxide)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (155) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl-N-oxide)propyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (156) N-[3-(4-chlorophenyl)-1(S)-methyl-2(S)-phenylpropyl]-2-(4-chloro-3,5-difluorophenyloxy)-2-methylpropanamide; (157) N-[3(R,S)-(4-chlorophenyl)-1(S),3-dimethyl-2(S)-phenylbutyl]-2-(3,5-difluoro-4-methylphenyloxy)-2-methylpropanamide; (158) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(6-methyl-3-pyridyloxy)-2-methylpropanamide; (159) N-[3-(4-chlorophenyl)-2-phenyl-1-methylpropyl]-2-(6-methyl-3-pyridyloxy)-2-methylpropanamide; (160) N-(1,4-dimethyl-2-phenylpentyl)-2-(4-chlorophenoxy)-2-methylpropanamide; (161) N-(1-methyl-2-phenylpentyl)-2-(4-chlorophenoxy)-acetamide; (162) N-(1-methyl-2,5-diphenylpentyl)-2-(4-chlorophenoxy)-acetamide; (163) N-(1,3-dimethyl-2-phenylpentyl)-2-(4-chlorophenoxy)-propanamide; (164) N-(2,3-diphenyl-1-methylpropyl)-2-(4-chlorophenoxy)-2-methylpropanamide; (165) N-(2,3-diphenyl-1-ethylpropyl)-2-(4-chlorophenoxy)-2-methylpropanamide; (166) N-(3-(4-chlorophenyl)-2-phenyl-1-methylpropyl)-2-(4-chlorophenoxy)-acetamide; (167) N-(2,3-diphenyl-1-methylpropyl)-2-(4-chlorophenoxy)-acetamide; (168) N-(3-(4-chlorophenyl)-2-phenyl-1-methylpropyl)-2-(4-chlorophenoxy)-propanamide; (169) N-(2,3-diphenyl-1-methylpropyl)-2-(4-chlorophenoxy)-propanamide; (170) N-(2,3-bis(4-chlorophenyl)-1-methylpropyl)-2-methyl-3-phenyl-propanamide; (171) N-(2,3-bis(4-chlorophenyl)-1-methylpropyl)-2-methyl-3-(4-chlorophenyl)-propanamide (172) N-(3-(4-chlorophenyl)-2-phenyl-1-methylpropyl)-2-(4-chloro-anilino)-acetamide; (173) N-(2,3-diphenyl-1-methylpropyl)-2-(4-chloro-anilino)-acetamide; (174) N-(2,3-bis(4-chlorophenyl)-1-methylpropyl)-2,2-dimethyl-3-phenyl-propanamide; (175) N-(3-(4-chlorophenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-propanamide; (176) N-(3-(2-chlorophenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-propanamide; (177) N-(3-(4-trifluoromethylphenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-propanamide; (178) N-(3-(4-fluorophenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-propanamide; (179) N-(3-(4-chlorophenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-phenoxy-propanamide; (180) N-(3-(4-chlorophenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-(4-fluorophenoxy)-propanamide; (181) N-(2,3-diphenyl-1-methylpropyl)-2-methyl-2-(4-fluorophenoxy)-propanamide; and (182) N-(3-phenyl-2-benzyl-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-propanamide; (183) N-[3(R)-(4-chlorophenyl)-1(S),3-dimethyl-2(S)-phenylbutyl]-2-(3,5-difluoro-4-methylphenyloxy)-2-methylpropanamide; (184) N-[3(S)-(4-chlorophenyl)-1(S),3-dimethyl-2(S)-phenylbutyl]-2-(3,5-difluoro-4-methylphenyloxy)-2-methylpropanamide; (386127/386129) (185) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (187) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (188) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (189) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-(3,5-dichlorophenyloxy)-2-methylpropanamide; (190) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (191) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-(3-chloro-5-fluorophenyloxy)-2-methylpropanamide; (192) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (193) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3-chloro-5-fluorophenyloxy)-2-methylpropanamide; (194) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (195) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (196) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (197) N-[2-(3-chlorophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (198) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (199) N-[2-(3-bromophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (200) N-[3-(4-chlorophenyl)-2-(3-iodophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (201) N-[2-(3-bromophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-methyl-2-(2-phenyloxy)propanamide; (202) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (203) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3-chloro-5-fluorophenyloxy)-2-methylpropanamide; (204) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (205) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (206) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (207) N-[2-(3-chlorophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (208) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(5-chloropyridyloxy)-2-methylpropanamide; (209) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(6-methylpyridyloxy)-2-methylpropanamide; (210) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-chloro-5-fluorophenyloxy)-2-methylpropanamide; (211) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-pyridazinyloxy)-2-methylpropanamide; (212) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4-trifluoromethylphenyloxy)-2-methylpropanamide; (213) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(5-trifluoromethylpyridyloxy)-2-methylpropanamide; (214) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4 6-dimethylpyridyloxy)-2-methylpropanamide; (215) N-(3-(4-chlorophenyl)-2-cyclopentyl-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (216) N-(3-(4-chlorophenyl)-2-cyclopentyl-1-methyl)propyl-2-(3,5-difluorophenoxy)-2-methylpropanamide; (217) N-(3-(4-chlorophenyl)-2-ethoxy-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (218) N-(3-(4-chlorophenyl)-2-isopropyl-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (219) N-(3-(4-chlorophenyl)-1-methyl-2-propoxy)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (220) N-(3-(4-chlorophenyl)-1-methyl-2-pentoxy)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (221) N-(3-(4-chlorophenyl)-2-cyclopentylmethoxy-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (222) N-(3-(4-chlorophenyl)-2-cyclobutylmethoxy-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (223) N-(3-(4-chlorophenyl)-2-ethyl-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (224) N-(3-(4-chlorophenyl)-2-ethyl-1-methyl)propyl-2-(3,5-difluorophenoxy)-2-methylpropanamide; (225) N-(3-(4-chlorophenyl)-2-methoxy-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (226) N-(3-(4-chlorophenyl)-2-pyrrolidin-N-yl-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (227) N-(3-(4-chlorophenyl)-2-benzyloxycarbonyl-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (228) N-(2-(1-(1,2,3-triazolyl))-3-(4-chlorophenyl)-1-methylpropyl)-2-(4-chlorophenyloxy)-2-methylpropanamide; (229) N-(2-(1-(1,2,4-triazolyl))-3-(4-chlorophenyl)-1-methylpropyl)-2-(2-pyridyloxy)-2-methylpropanamide; and pharmaceutically acceptable salts thereof.

9. The compound according to claim 1, wherein: R¹is selected from: (1) ethyl, (2) isopropyl, (3) isobutyl, (4) n-propyl, (5) n-pentyl, (6) cyclopentyl, (7) pyrrolidinyl, (8) phenyl, (9) phenyl-C_1-4alkyl, (10) pyridyl, (11) pyridyl-C_1-4alkyl, (12) triazolyl, (13) ethyloxy, (14) propyloxy, (15) butyloxy, (16) n-pentyloxy, (17) benzyloxylcarbonyl, (18) cyclopentylmethyloxy, and (19) cyclobutylmethyloxy, wherein each phenyl and pyridyl are optionally substituted with one or two substituents selected from halogen, methyl, trifluoromethyl, cyano and methoxy, and each pyridyl is optionally present as the N-oxide. R²is selected from: (1) isopropyl, (2) isobutyl, (3) n-propyl, (4) phenyl, (5) benzyl, (6) phenylethyl, (7) 3-phenylpropyl, (8) 2-phenylpropyl, (9) phenoxy, (10) phenylthio, and (11) pyridylmethyl, wherein each aryl and heteroaryl is optionally substituted with one or two R^bsubstituents selected from halogen, trifluoromethyl, cyano, methoxycarbonyl, and methoxy. R³is selected from: (1) hydrogen, (2) methyl, and (3) ethyl; R⁴is hydrogen; R⁵is C_1-8alkyl substituted with —OR^d; R^dis selected from: (1) hydrogen, (2) C_1-4alkyl, (3) C_2-6alkenyl, (4) cycloalkyl, (5) cycloalkyl-C_1-4alkyl, (6) cycloheteroalkyl, (7) cycloheteroalkyl-C_1-4alkyl, (8) phenyl, (9) heteroaryl, (10) phenyl-C_1-4alkyl, and (11) heteroaryl-C_1-4alkyl, wherein each R^dmay be unsubstituted or substituted with one to three substituents selected from R^h; each R^his independently selected from: (1) halogen, (2) C_1-4alkyl, (3) —O—C_1-4alkyl, (4) —S—C_1-4alkyl, (5) —CN, (6) —CF₃, and (7) —OCF₃; and pharmaceutically acceptable salts thereof.

10. The compound according to claim 9, selected from: (1) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (2) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-cyclohexyloxy)-2-methylpropanamide; (3) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(2-fluorophenyloxy)-2-methylpropanamide; (4) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3-fluorophenyloxy)-2-methylpropanamide; (5) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3,4-difluorophenyloxy)-2-methylpropanamide; (6) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (7) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(2-chlorophenyloxy)-2-methylpropanamide; (8) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (9) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3-cyanophenyloxy)-2-methylpropanamide; (10) N-[3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (11) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-phenyloxy-2-methylpropanamide; (12) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (13) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(3-pyridyloxy)-2-methylpropanamide; (14) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(2-pyridylox)-2-methylbutanamide; (15) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (16) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-pyridyloxy)-2-methylpropanamide; (17) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-fluorophenyloxy)-2-methylpropanamide; (18) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-fluorophenyloxy)-2-methylpropanamide; (19) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3,4-difluorophenyloxy)-2-methylpropanamide; (20) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (21) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-chlorophenyloxy)-2-methylpropanamide; (22) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (23) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-cyclohexyloxy-2-methylpropanamide; (24) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (25) N-[3-(4-chlorophenyl)-2-(2-fluorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (26) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (27) N-[3-(4-chlorophenyl)-2-(2-fluorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (28) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl)]-2-methyl-2-phenylpropanamide; (29) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (30) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (31) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (32) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-pyridyloxy)-2-methylpropanamide; (33) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-pyridyloxy)-2-methylbutanamide; (34) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (35) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4-pyridyloxy)-2-methylpropanamide; (36) N-[2-(4-chlorophenyl)-1-methyl-3-phenylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (37) N-[2-(4-chlorophenyl)-1-methyl-3-phenylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (38) N-[2-(4-chlorophenyl)-1-methyl-3-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (39) N-[2-(4-chlorophenyl)-1-methyl-3-phenylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (40) N-[3-(4-methoxycarbonylphenyl)-1-methyl-2-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (41) N-[3-(4-methoxycarbonylphenyl)-1-methyl-2-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (42) N-[3-(4-methoxycarbonylphenyl)-1-methyl-2-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (43) N-[3-(4-methoxycarbonylphenyl)-1-methyl-2-phenylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (44) N-[2-(2-chlorophenyl)-1-methyl-3-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (45) N-[2-(2-chlorophenyl)-1-methyl-3-phenylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (46) N-[2-(4-methoxyphenyl)-1-methyl-3-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (47) N-[2-(4-methoxyphenyl)-1-methyl-3-phenylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (48) N-[2-(4-chlorophenyl)-3-(2,4-dichlorophenyl)-1-methyl-propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (49) N-[2-(4-chlorophenyl)-2-(4-chloro 2-fluorophenyl)-1-methyl-propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (50) N-[2-(4-chlorophenyl)-2-(4-chloro-2-fluorophenyl)-1-methyl-propyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (51) N-[3-(4-chlorophenyl)-2-(4-fluorophenyl)-1-methyl-propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (52) N-[3-(4-chlorophenyl)-1-methyl-2-(2-pyridyl)propyl]-tert-butylcarbamate; (53) N-[3-(4-chlorophenyl)-1-methyl-2-(2-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (54) N-[3-(4-chlorophenyl)-1-methyl-2-(4-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (55) N-[3-(4-cyanophenyl)-1-methyl-2-phenylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (56) N-[3-(5-chloro-2-pyridyl)-1-methyl-2-phenylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (57) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-tert-butylcarbamate; (58) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (59) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (60) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(3-fluorophenyloxy)-2-methylpropanamide; (61) N-[2-(4-chlorophenoxy)-2-(4-chlorophenyl)ethyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (62) N-[2,2-bis(4-chlorophenyl)ethyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (63) N-[2-(4-chlorophenylthio)-2-(4-chlorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (64) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (65) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-phenyloxy-2-methylpropanamide; (66) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (67) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(6-methyl-3-pyridyloxy)-2-methylpropanamide; (68) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-fluorophenyloxy)-2-methylpropanamide; (69) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3,4-difluorophenyloxy)-2-methylpropanamide; (70) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3,4-difluorophenyloxy)-2-methylpropanamide; (71) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (72) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (73) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (74) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(4-fluorophenyloxy)-2-methylpropanamide; (75) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (76) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (77) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (78) N-[3-(4-chlorophenyl)-1-methyl-2-(2-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (79) N-[3-(4-cyanophenyl)-1-methyl-2-phenylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (80) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (81) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (82) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(3-fluorophenyloxy)-2-methylpropanamide; (83) N-[2-(4-chlorophenoxy)-2-(4-chlorophenyl)ethyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (84) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (85) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3,4,5-trifluorophenyloxy)-2-methylpropanamide; (86) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3-chloro-4-fluorophenyloxy)-2-methylpropanamide; (87) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(4-chloro-3-fluorophenyloxy)-2-methylpropanamide; (88) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3,4-dichlorophenyloxy)-2-methylpropanamide; (89) N-[3-(4-chlorophenyl)-2(S)-phenyl-1(S)-methylpropyl]-2-(3,5-dichlorophenyloxy)-2-methylpropanamide; (90) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-pyridyloxy-N-oxide)-2-methylpropanamide; (91) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl-N-oxide)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (92) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl-N-oxide)propyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (93) N-[3-(4-chlorophenyl)-1(S)-methyl-2(S)-phenylpropyl]-2-(4-chloro-3,5-difluorophenyloxy)-2-methylpropanamide; (94) N-[3(R,S)-(4-chlorophenyl)-1(S),3-dimethyl-2(S)-phenylbutyl]-2-(3,5-difluoro-4-methylphenyloxy)-2-methylpropanamide; (95) N-[2,3-bis(4-chlorophenyl)-1-methylpropyl]-2-(6-methyl-3-pyridyloxy)-2-methylpropanamide; (96) N-[3-(4-chlorophenyl)2-phenyl-1-methylpropyl]-2-(6-methyl-3-pyridyloxy)-2-methylpropanamide; (97) N-(1,4-dimethyl-2-phenylpentyl)-2-(4-chlorophenoxy)-2-methylpropanamide; (98) N-(2,3-diphenyl-1-methylpropyl)-2-(4-chlorophenoxy)-2-methylpropanamide; (99) N-(2,3-diphenyl-1-ethylpropyl)-2-(4-chlorophenoxy)-2-methylpropanamide; (100) N-(3-(4-chlorophenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-propanamide; (101) N-(3-(2-chlorophenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-propanamide; (102) N-(3-(4-trifluoromethylphenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-propanamide; (103) N-(3-(4-fluorophenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-propanamide; (104) N-(3-(4-chlorophenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-phenoxy-propanamide; (105) N-(3-(4-chlorophenyl)-2-phenyl-1-methylpropyl)-2-methyl-2-(4-fluorophenoxy)-propanamide; (106) N-(2,3-diphenyl-1-methylpropyl)-2-methyl-2-(4-fluorophenoxy)-propanamide; and (107) N-(3-phenyl-2-benzyl-1-methylpropyl)-2-methyl-2-(4-chlorophenoxy)-propanamide; (108) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-2-methylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (109) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-methyl-2-(3,4,5-trifluorophenyloxy)propanamide; (110) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (111) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (112) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-(3,5-dichlorophenyloxy)-2-methylpropanamide; (113) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (114) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-(3-chloro-5-fluorophenyloxy)-2-methylpropanamide; (115) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (116) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3-chloro-5-fluorophenyloxy)-2-methylpropanamide; (117) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (118) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (119) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (120) N-[2-(3-chlorophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (121) N-[2-(3-bromophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (122) N-[3-(4-chlorophenyl)-2-(3-iodophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (123) N-[2-(3-bromophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-methyl-2-(2-phenyloxy)propanamide; (124) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (125) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3-chloro-5-fluorophenyloxy)-2-methylpropanamide; (126) N-[3-(4-chlorophenyl)-2-(3-fluorophenyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (127) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (128) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (129) N-[2-(3-chlorophenyl)-3-(4-chlorophenyl)-1-methylpropyl]-2-methyl-2-(2-pyridyloxy)propanamide; (130) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(5-chloropyridyloxy)-2-methylpropanamide; (131) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(6-methylpyridyloxy)-2-methylpropanamide; (132) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-chloro-5-fluorophenyloxy)-2-methylpropanamide; (133) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-pyridazinyloxy)-2-methylpropanamide; (134) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4-trifluoromethylphenyloxy)-2-methylpropanamide; (135) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(5-trifluoromethylpyridyloxy)-2-methylpropanamide; (136) N-[(2S,3S)-3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4,6-dimethylpyridyloxy)-2-methylpropanamide; (137) N-(3-(4-chlorophenyl)-2-cyclopentyl-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (138) N-(3-(4-chlorophenyl)-2-cyclopentyl-1-methyl)propyl-2-(3,5-difluorophenoxy)-2-methylpropanamide; (139) N-(3-(4-chlorophenyl)-2-ethoxy-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (140) N-(3-(4-chlorophenyl)-2-isopropyl-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (141) N-(3-(4-chlorophenyl)-1-methyl-2-propoxy)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (142) N-(3-(4-chlorophenyl)-2-cyclobutylmethoxy-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (143) N-(3-(4-chlorophenyl)-2-ethyl-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (144) N-(3-(4-chlorophenyl)-2-ethyl-1-methyl)propyl-2-(3,5-difluorophenoxy)-2-methylpropanamide; (145) N-(3-(4-chlorophenyl)-2-methoxy-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (146) N-(3-(4-chlorophenyl)-2-pyrrolidin-N-yl-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (147) N-(3-(4-chlorophenyl)-2-benzyloxycarbonyl-1-methyl)propyl-2-(3,5-dichlorophenoxy)-2-methylpropanamide; (148) N-(2-(1-(1,2,3-triazolyl))-3-(4-chlorophenyl)-1-methylpropyl)-2-(4-chlorophenyloxy)-2-methylpropanamide; (149) N-(2-(1-(1,2,4-triazolyl))-3-(4-chlorophenyl)-1-methylpropyl)-2-(2-pyridyloxy)-2-methylpropanamide; and pharmaceutically acceptable salts thereof.

11. The compound according to claim 3, wherein: R¹is selected from: (1) cycloheteroalkyl, (2) aryl, (3) heteroaryl, and (4) —NR^cR^d; wherein aryl and heteroaryl are optionally substituted with one to three substituents independently selected from R^b; R²is selected from: (1) C_1-10alkyl, (2) C_3-10cycloalkyl-C_1-alkyl, (3) aryl-C_1-4alkyl, (4) heteroaryl-C_1-4alkyl, wherein each cycloalkyl, aryl and heteroaryl is optionally substituted with one to three substituents independently selected from R^b; R³is methyl; R⁴is hydrogen; R⁵is 619 embedded image

each R^bis independently selected from: (1) halogen, (2) cyano, (3) trifluoromethyl, (4) trifluoromethoxy, (5) C_1-3alkyloxy, and (6) C_1-3alkyl; each R^cis independently selected from (1) hydrogen, (2) methyl, and (3) trifluoromethyl; R^dis independently selected from: (1) hydrogen, (2) C_1-6alkyl, (3) cycloalkyl, (4) aryl, (5) heteroaryl, (6) arylmethyl, and. (7) heteroarylmethyl, each R^dmay be unsubstituted or substituted with one to three substituents selected from R^h; each R^his independently selected from: (1) halogen, (2) C_1-3alkyl, (3) —CN, and (4) —CF₃; wherein when pyridyl groups are unsubstituted on the nitrogen, they are may optionally be present as the N-oxide; and pharmaceutically acceptable salts thereof.

12. The compound according to claim 11, wherein: R¹is selected from: (1) phenyl, (2) pyridyl, (3) indolyl, (4) 7-aza-indolyl, (5) thiophenyl, and (6) 620 embedded image

wherein each aryl and heteroaryl is optionally substituted with one or two substitutents independently selected from R^b, and each pyridyl may be optionally present as the N-oxide; R²is selected from: (1) C_1-6alkyl, (2) C_3-6cycloalkylmethyl, (3) phenylmethyl, (4) heteroarylmethyl, wherein each cycloalkyl, aryl and heteroaryl is optionally substituted with one to three substituents independently selected from R^b; each R^bis independently selected from: (1) halogen, (2) cyano, (3) C_1-3alkyloxy, and (4) C_1-3alkyl; R^dis selected from: (1) phenyl, (2) pyridyl, and (3) pyrimidinyl, wherein R^dmay be unsubstituted or substituted with one or two substituents selected from R^h; each R^his independently selected from: (1) fluoro, (2) chloro, (3) methyl, (4) —CN, and (5) —CF₃; and pharmaceutically acceptable salts thereof.

13. The compound according to claim 12, selected from: (1) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (2) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (3) N-[3-(4-chlorophenyl)-1-methyl-2-(3-pyridyl)propyl]-2-(4-chlorophenyloxy)-2-methylpropanamide; (4) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3,5-difluorophenyloxy)-2-methylpropanamide; (5) N-[3-(4-chlorophenyl)-2-phenyl-1methylpropyl]-2-(3,5-dichlorophenyloxy)-2-methylpropanamide; (6) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(3-chlorophenyloxy)-2-methylpropanamide; (7) N-[3-(4-chlorophenyl)-2-(3,5-difluorophenyl)-1-methylpropyl]-2-(2-pyridyloxy)-2-methylpropanamide; (8) N-[3-(4-chlorophenyl)-1-methyl-2-phenyl-propyl]-2-(5-chloro-2-pyridyloxy)-2-methylpropanamide; (9) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(6-methyl-pyridyloxy)-2-methylpropanamide; (10) N-[3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(phenyloxy)-2-methylpropanamide; (11) N-[(3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(5-trifluoromethylpyridyloxy)-2-methylpropanamide; (12) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (13) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (14) N-[3-(4-chlorophenyl)-2-(5-chloro-3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (15) N-[3-(4-chlorophenyl)-2-(5-methyl-3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (16) N-[3-(4-chlorophenyl)-2-(5-cyano-3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (17) N-[3-(4-chlorophenyl)-2-(3-methylphenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (18) N-[3-(4-chlorophenyl)-2-phenyl-1-methylpropyl]-2-(4-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (19) N-[3-(4-chlorophenyl)-2-phenyl-1-methylpropyl]-2-(4-trifluoromethyl-2-pyrimidyloxy)-2-methylpropanamide; (20) N-[3-(4-chlorophenyl)-1-methyl-2-(thiophen-3-yl)propyl]-2-(5-chloro-2-pyridyloxy)-2-methylpropanamide; (21) N-[3-(5-chloro-2-pyridyl)-2-phenyl-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (22) N-[3-(4-methyl-phenyl)-1-methyl-2-phenylpropyl]-2-(4-trifluoromethyl-phenyloxy)-2-methylpropanamide; (23) N-[3-(4-fluoro-phenyl)-2-(3-cyano-phenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (24) N-[3-(4-chlorophenyl)-2-(1-indolyl)-1-methyl)propyl]-2-(5-trifluoromethyl-2-oxypyridine-2-yl)-2-methylpropanamide; (25) N-[3-(4-chlorophenyl)-2-(7-azaindol-N-yl)-1-methyl)propyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (26) N-[3-(4-chloro-phenyl)-2-(1-indolinyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (27) N-[3-(4-chloro-phenyl)-2-(N-methyl-anilino)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (28) N-[3-(4-methoxy-phenyl)-2-(3-cyano-phenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (29) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(6-trifluoromethyl-4-pyrimidyloxy)-2-methylpropanamide; (30) N-[2-(3-cyanophenyl)-1,4-dimethylpentyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (31) N-[3-(4-chlorophenyl)-2-(1-oxido-5-cyano-3-pyridyl]-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (32) N-[2-(3-cyanophenyl)-3-cyclobutyl-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (33) N-[2-(3-cyanophenyl)-1-methyl-heptyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (34) N-[2-(3-cyanophenyl)-3-cyclopentyl-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (35) N-[2-(3-cyanophenyl)-3-cyclohexyl-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; and pharmaceutically acceptable salts thereof.

14. The compound according to claim 12, wherein R^dis 5-trifluoromethyl-2-pyridyl; and pharmaceutically acceptable salts thereof.

15. The compound according to claim 14 selected from: (1) N-[(3-(4-chlorophenyl)-1-methyl-2-phenylpropyl]-2-(5-trifluoromethylpyridyloxy)-2-methylpropanamide; (2) N-[3-(4-chlorophenyl)-2-(3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (3) N-[3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (4) N-[3-(4-chlorophenyl)-2-(5-chloro-3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (5) N-[3-(4-chlorophenyl)-2-(5-methyl-3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (6) N-[3-(4-chlorophenyl)-2-(5-cyano-3-pyridyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (7) N-[3-(4-chlorophenyl)-2-(3-methylphenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (8) N-[3-(5-chloro-2-pyridyl)-2-phenyl-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (9) N-[3-(4-fluoro-phenyl)-2-(3-cyano-phenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (10) N-[3-(4-chlorophenyl)-2-(1-indolyl)-1-methyl)propyl]-2-(5-trifluoromethyl-2-oxypyridine-2-yl)-2-methylpropanamide; (11) N-[3-(4-chlorophenyl)-2-(7-azaindol-N-yl)-1-methyl)propyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (12) N-[3-(4-chloro-phenyl)-2-(1-indolinyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (13) N-[3-(4-chloro-phenyl)-2-(N-methyl-anilino)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (14) N-[3-(4-methoxy-phenyl)-2-(3-cyano-phenyl)-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (15) N-[2-(3-cyanophenyl)-1,4-dimethylpentyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (16) N-[3-(4-chlorophenyl)-2-(1-oxido-5-cyano-3-pyridyl]-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (17) N-[2-(3-cyanophenyl)-3-cyclobutyl-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (18) N-[2-(3-cyanophenyl)-1-methyl-heptyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (19) N-[2-(3-cyanophenyl)-3-cyclopentyl-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; (20) N-[2-(3-cyanophenyl)-3-cyclohexyl-1-methylpropyl]-2-(5-trifluoromethyl-2-pyridyloxy)-2-methylpropanamide; and pharmaceutically acceptable salts thereof.

16. A method of treating a disease mediated by the Cannabinoid-1 receptor comprising administration to a patient in need of such treatment of a therapeutically effective amount of a compound according to claim 1.

17. The method according to claim 16 wherein the disease mediated by the Cannabinoid-1 receptor is selected from: psychosis, memory deficit, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders, cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, schizophrenia, substance abuse disorders, constipation, chronic intestinal pseudo-obstruction, cirrhosis of the liver, asthma, obesity, and other eating disorders associated with excessive food intake.

18. The method according to claim 17 wherein the disease mediated by the Cannabinoid-1 receptor is an eating disorder associated with excessive food intake.

19. The method according to claim 18 wherein the eating disorder asssociated with excessive food intake is selected from obesity, bulimia nervosa, and compulsive eating disorders.

20. The method according to claim 19 wherein the eating disorder associated with excessive food intake is obesity.

21. A method of preventing obesity in a person at risk for obesity comprising administration to said person of about 0.001 mg to about 100 mg per kg of a compound according to claim 1.

22. A composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier.

23. The use of a compound according to claim 1, for the manufacture of a medicament useful for the treatment of a disease mediated by the Cannabinoid-1 receptor in a human patient in need of such treatment.

24. The use according to claim 23 wherein the disease mediated by the Cannabinoid-1 receptor is selected from: psychosis, memory deficit, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders, cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, schizophrenia, substance abuse disorders, constipation, chronic intestinal pseudo-obstruction, cirrhosis of the liver, asthma, obesity, and other eating disorders associated with excessive food intake.

25. The use according to claim 24 wherein the disease mediated by the Cannabinoid-1 receptor is an eating disorder associated with excessive food intake.

26. The use according to claim 25, wherein the eating disorder asssociated with excessive food intake is selected from obesity, bulimia nervosa, and compulsive eating disorders.

27. The use according to claim 26 wherein the eating disorder associated with excessive food intake is obesity.

28. The use of a compound according to claim 1 for the manufacture of a medicament for the prevention of obesity in a person at risk therefor.

29. A compound of structural formula I: 621 embedded image

Description:

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] Not applicable.

BACKGROUND OF THE INVENTION

[0002] Marijuana ( Cannabis sativa L. ) and its derivatives have been used for centuries for medicinal and recreational purposes. A major active ingredient in marijuana and hashish has been determined to be Δ ⁹ -tetrahydrocannabinol (Δ ⁹ -THC). Detailed research has revealed that the biological action of Δ ⁹ -THC and other members of the cannabinoid family occurs through two G-protein coupled receptors termed CB1 and CB2. The CB1 receptor is primarily found in the central and peripheral nervous systems and to a lesser extent in several peripheral organs. The CB2 receptor is found primarily in lymphoid tissues and cells. Three endogenous ligands for the cannabinoid receptors derived from arachidonic acid have been identified (anandamide, 2-arachidonoyl glycerol, and 2-arachidonyl glycerol ether). Each is an agonist with activities similar to Δ ⁹ -THC, including sedation, hypothermia, intestinal immobility, antinociception, analgesia, catalepsy, anti-emesis, and appetite stimulation.

[0003] The genes for the respective cannabinoid receptors have each been disrupted in mice. The CB1 ^-/- receptor knockout mice appeared normal and fertile. They were resistant to the effects of Δ ⁹ -THC and demonstrated a strong reduction in the reinforcing properties of morphine and t